Gluten and Casein signifies that infections are crossing the major barriers: the intestine or the blood-brain-barrier !!!

Gluten and casein sensitivity may mean that an infection has broken through a tight barrier like the intestine or brain's blood barrier.

Does casein-alpha or gluten alter the IFN which then allows the BBB or the lumen to open for bacterial infections to cross? 

Under normal conditions IFN is a cytokine, a immune system message, to tell macrophages to come eat something.   If IFN levels are raised too high in an area the barrier wall epithelial layer goes through changes.  (zonulin included ) Which means that infections which try to cross either the blood brain barrier or the lumen would have an easier time. 

The hypothesis is that the high IFN levels from a gluten and casein sensitive state would create antibodies but not autoimmune disease until a virus infects the same area causing cross-targeting.

Cross-targeting autoimmune hypothesis is 2 infections on one target, one organ, confuse the immune system into attacking self.  An outer infection to uncouple the B cell's education and an inner infection to uncouple a T cell's education.

Gluten sensitivity alone is not an indicator of autoimmune disease rather that an infection exists that breaks barriers.

First let us look at the gluten and casein connection to IFN.

differences alpha, beta, gamma IFN
http://www.ncbi.nlm.nih.gov/pubmed/7993128

all are involved with cell growth inhibition in addition to being part of the immune system cytokines against viruses...all can open the Blood Brain Barrier or BBB

Casein-alpha upregulates IFN-alpha genes thus functions as a tumor suppressor
http://www.landesbioscience.com/journals/cc/2012CC4423.pdf 

temporary bbb crossing blocked but long term opens it?
http://www.researchgate.net/publication/5257154_Interferon-beta_prevents_cytokine-induced_neutrophil_infiltration_and_attenuates_blood-brain_barrier_disruption

Gluten stimulates more IFN-gamma expression is gluten inhibiting it?
http://www.gastrojournal.org/article/S0016-5085%2898%2970134-9/abstract 
http://www.ncbi.nlm.nih.gov/pubmed/9721152 
http://www.ncbi.nlm.nih.gov/pubmed/23588237
http://www.ncbi.nlm.nih.gov/pubmed/17919493

IFN-γ participates in cerebral malaria pathogenesis by affecting endothelial integrity
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133756/

f-actin and gluten
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1809109/

e.coli, f-actin and the BBB
http://www.ncbi.nlm.nih.gov/pubmed/24932957

casein from milk increases mycobacteria invasion
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459753/

B-casein from bacteria and cellular motility /invasion?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC275444/
pretty pictures of what casein induces and the visualizing of actin (same article)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC275444/figure/cdg586f4/

Current hypothesis list of gluten and casein sensitive culprits connected to autoimmune diseases:

e.coli celiac
sutterella autism
mycobacteria psoriasis/parkinson's
 t.gondii schizophrenia
strep tourettes (non genetic)

e.coli and gluten
http://www.ncbi.nlm.nih.gov/pubmed/26456581

Strep and gluten
http://www.ncbi.nlm.nih.gov/pubmed/15814071

t.gondii and gluten sensitivity
http://www.ncbi.nlm.nih.gov/pubmed/23209841

psoriasis and gluten
http://www.ncbi.nlm.nih.gov/pubmed/25603678

psoriasis and mycobacteria

gluten and pychosis
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517012/


If they all are gluten sensitive because they cross the BBB (blood brain barrier) does that mean that Strep would be gluten sensitive because it is notorious for crossing and has been known to be involved with PANDAS which involves antibodies passing through a BBB to get to the brain.

Anyone out there able to look at strep and see if it is gluten and casein sensitive?
http://www.ncbi.nlm.nih.gov/pubmed/15814071
http://curemyth1.org/forum2/3860.html
http://wheatfreediseasefree.com/2012/04/23/keep-the-tonsils-pull-the-strep-throat/
We so quickly give people antibiotics I am not sure we will know.

strep and OCD?
http://www.ncbi.nlm.nih.gov/pubmed/15995031

OCD and gluten? is this strep or e.coli
http://www.ncbi.nlm.nih.gov/pubmed/?term=ocd+gluten

In case you did not know that e.coli crossed the BBB
http://iai.asm.org/content/69/9/5217.full?sid=41faac6f-bc5d-4015-bd6d-8f733682da01 

strep and ataxia
http://www.ncbi.nlm.nih.gov/pubmed/15814071 

Zonulin is also an interesting dimension appearing at the lumen of the gut and the blood brain barrier
http://www.ncbi.nlm.nih.gov/pubmed/23637756
http://www.ncbi.nlm.nih.gov/pubmed/22731712


How does all this fit together? Transglutaminase and cross-targeting?

viral infections can  cause the generation of Transglutaminase
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810390/

further EBV may set off more than one type of colon autoimmune disease (not just celiac)
http://www.ncbi.nlm.nih.gov/pubmed/10364028

Infections like e.coli or strep which would cross the lumen or BBB with increased ease with gluten and casein would already have the generated and immune attack there in the colon but it would not be autoimmune until cross-targeted with a virus.

In other words it is not the "crossing of gluten and casein"  that we should  fear rather the  cross-targeting of infections and the antibodies that target us.

3/5/2015 new post http://angelabiggs.blogspot.com/2015/03/infections-that-break-tight-junction.html

New paper linking intestinal lumen and the BBB. When the intestine becomes stronger so does the BBB.
http://www.ncbi.nlm.nih.gov/pubmed/25411471