Monday, September 29, 2014

Guillain barre syndrome and autoimmune cross-targeting

Guillain Barre

Old blog post: http://angelabiggs.blogspot.com/2013/04/does-location-of-bacteria-decide-which.html

Current virus hitting denver and paralysis is not Guillan Barre
http://abcnews.go.com/Health/cdc-investigates-limb-paralysis-children-enterovirus-68-outbreak/story?id=25804998
They found anti-phospholipid antibodies. So it is the autoimmune disease transverse myelopathy which overlaps sjogren's.
http://www.ncbi.nlm.nih.gov/pubmed/10930601

My Hypothesis:
Cross-targeting:  the layering of 2 different infections on one target causes autoimmune disease.  A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria..etc.. infection marking the outside.

In the case of Guillain Barre

Campylobacter jejuni
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC128258/ 
http://www.ncbi.nlm.nih.gov/pubmed/24107359 
http://www.ncbi.nlm.nih.gov/pubmed/16829615

Enterovirus
http://www.ncbi.nlm.nih.gov/pubmed/16269848

other viruses might trigger the cross-targeting
http://www.ncbi.nlm.nih.gov/pubmed/24800041 

c.jejuni and the lungs ??? some cases of asthma????
http://www.unboundmedicine.com/medline/citation/24611115/Campylobacter_jejuni_infection_of_infant_mice:_acute_enterocolitis_is_followed_by_asymptomatic_intestinal_and_extra_intestinal_immune_responses_ 

Indirect connection H.pylori protects against early on-set asthma and c.jejuni
http://www.ncbi.nlm.nih.gov/pubmed/?term=c.+jejuni+asthma

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