Friday, September 26, 2014

Are cataracts caused by autoimmunity?


Antibodies against lens proteins in Cataract patients
http://www.ncbi.nlm.nih.gov/pubmed/15636218
http://www.ncbi.nlm.nih.gov/pubmed/3111983

crystallins and cataracts
http://www.ncbi.nlm.nih.gov/pubmed/19007775

senile cataract: no infection? old age?
http://www.ncbi.nlm.nih.gov/pubmed/19023447 

why would our bodies generate antibodies against crystallin? have some of these infections started using crystallin? http://www.ncbi.nlm.nih.gov/pmc/articles/PMC43774/    It appears bacteria can look similar!!

Looking for overlaps with infections and this bacteria...staph
http://jb.asm.org/content/early/2014/09/23/JB.02217-14.abstract?related-urls=yes&legid=jb;JB.02217-14v1

Crystallins appear to be used by the immune system to protect the eye during infection too.
http://www.ncbi.nlm.nih.gov/pubmed/19860667

  Is it used by the immune system elsewhere?

crystallins in autoimmune diseases
http://www.google.com/patents/EP0764273B1?cl=en
(note that i have suggested that staph or mycobacteria are involved in triggering MS with cross-targeting autoimmunity)

the accumulations of cyrstallin in the central nervous system
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1886422/pdf/amjpathol00086-0102.pdf
http://www.ncbi.nlm.nih.gov/pubmed/11200685

MS and crystallins
http://www.ncbi.nlm.nih.gov/pubmed/16764341
http://med.stanford.edu/news/all-news/2007/06/stanford-researchers-clarify-proteins-role-in-multiple-sclerosis.html
http://www.ncbi.nlm.nih.gov/pubmed/10478576


cataracts and eczema (staph)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2161383/
http://www.bmj.com/content/1/4183/356
books.google.com/books?id=5R8JRtYmleAC&pg=PA126&lpg=PA126&dq=eczema+cataract&source=bl&ots=CMO_9pOTLm&sig=r3k672TmqoCpluPWFOYOQ27HsKE&hl=en&sa=X&ei=K5MlVMmPIYaayQTOyoKQDw&ved=0CC8Q6AEwAzgK#v=onepage&q=eczema cataract&f=false 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292870/

Staph and crystallin
http://www.ncbi.nlm.nih.gov/pubmed/18227158
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292870/


cataracts and psoriasis/ type 2 diabetes (mycobacteria)
http://www.ncbi.nlm.nih.gov/pubmed/3805392
http://www.uveitis.org/docs/dm/psoriatic_arthritis.pdf 

mycobacteria and crystallins
http://www.ncbi.nlm.nih.gov/pubmed/15778386

cataracts and type 1 diabetes/celiac (e.coli)
http://www.ncbi.nlm.nih.gov/pubmed/21624959

celiac and crystallins
http://www.ncbi.nlm.nih.gov/pubmed/11593501

So several bacterias need to be checked to see if their coat has crystallin:
staph, e.coli, and mycobacterias

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