Hypothesis: The cross-targeting of infections at the same tissue causes
autoimmune disease. One infection marks the outside while another marks
the inside...only then does the immune system become confused and
attack
Please see newer post: http://angelabiggs.blogspot.com/2015/02/over-view-of-brain-autoimmunity.html
I started to post how my cross-targeting theory applies to PANDAS, Tourettes, OCD and narcolepsy...and then I remembered Encephalitis Lethargica.
Before I start posting suspects and demonstrating the cross-targeting on the Basal Ganglia that I suspect I need to respectfully identify Dr. Andrew Church who works on Encephalitis Lethargia.
Everyone remembers the 1990 Awakenings movie with Robin Williams as Dr. Oliver who in 1918 dealt with an cluster of encephalitis lethargia patients. In 1993 Dr. Andrew Church found himself with another Encephalitis cluster and he discovered that 2 infections were there not just the flu. Dr. Andrew discovered that a high number of his patients had a rare form of strep called Diplococcus along with the spanish flu. He has spent a life time trying to piece together this disease.
In 2011 Dr. Andrew came out with this paper proving Encelpalitis lethargia was an autoimmune disease with antibodies directed at the Basal Ganglia. http://brain.oxfordjournals.org/content/127/1/21.full.pdf
Here today I am looking at the autoimmune diseases that cross-target on the Basal Ganglia. In this case the severity of the disease may depend on what mix you had causing the cross-targeting. My theory supports and validates his research.
Other Basal ganglia autoimmune diseases: http://qjmed.oxfordjournals.org/content/96/3/183.full
The NY cluster of LeRoy High PANDAS cluster. Dr. Trifiletti has also found 2 infections involved with this autoimmune disease which targets the Basal Ganglia. He has found Streptococcus pyogenes in 5 of the 8 girls and Mycoplasma pneumonia in 7 of the 8.
Parents of PANDA children have discovered their kids can relapse even after antibiotic recovery when their children receive a flu shot. I believe this is because the flu shot generates antibodies against the Basal Ganglia.
In England a cluster of children developed Narcolepsy which is a disorder of the basal ganglia after receiving a swine flu shot. The question is did they have another infection's antibodies there too? What infection broke the brain's blood barrier?
Update 6/29 History of strep was found in Narcolepsy patients
http://med.stanford.edu/psychiatry/narcolepsy/articles/ResponseToMarcusH1n1.pdf
Antibodies for strep found in narcolepsy patients
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717204/pdf/aasm.32.8.979.pdf
Tourettes has been associated not just with strep but with borrellia burgdorferi (lyme disease). Although I am about to show a connection with Lyme I think there exists a genetic disposition where only strep is required to develop the autoimmune reaction but this would be the kind of Tourettes that runs in families. (Rheumatic fever which is also an autoimmune reaction to strep has a genetic component and runs in my family....strep alone causes the autoimmune response of the joints etc)
Lyme and Tourettes:
http://www.ncbi.nlm.nih.gov/pubmed/15590039
http://www.tourette-gesellschaft.de/download/bts_lymedisease_muelleretal.pdf
http://www.ncbi.nlm.nih.gov/pubmed/9482302
Tourettes and lyme (this link added 2016)
http://abcnews.go.com/Health/girl-tics-bucks-doctors-blames-lyme-disease/story?id=19128125
My cross-targeting hypothesis is supported when one looks at the Basal Ganglia related autoimmune diseases. In order for autoimmune disease to develop 2 infections typically exist both causing the immune system to target the same thing.
Encephalitis lethargia: strep and spanish flu virus (H1N1 subtype not seen right now)
Tourettes: strep/ lyme's Borrellia and herpes ?
PANDAS/OCD: strep / mycobacteria and swine flu (common H1N1?)
Parkinson's: mycobacteria and avian flu virus
Cataplexy : strep and swine flu
Looking at this list Strep stands out. Strep definitely can get through or weaken the Blood Brain Barrier. http://blog.lib.umn.edu/nich0185/myblog/2011/10/the-blood-brain-barrier-and-ocd.html
http://nizetlab.ucsd.edu/publications/iaga-jci.pdf
The borriella of lyme disease drills a hole for itself through the barrier.
http://www.ncbi.nlm.nih.gov/pubmed/22355605
Mycobacteria weave their way through the barrier.
http://www.ncbi.nlm.nih.gov/pubmed/16586367
Once the protective barrier of the brain is down the antibodies seep through. All of these infections focus the immune system on the Basal Ganglia as a target but the mix you have could determine which disease you have?
Herpes and Tourettes references:
http://www.ncbi.nlm.nih.gov/pubmed/?term=herpes+virus+tourettes
http://www.ncbi.nlm.nih.gov/pubmed/3195682
http://www.autism.com/ari/newsletter/112/page2.pdf
http://www.ncbi.nlm.nih.gov/pubmed/18378549 (basal ganglia,herpes and movement)
Note that there are multiple types of swine flu and the CDC needs to start tracking which flu is associated with which autoimmune disease. (which swine flu etc since there are different ones)
The idea is: the outside of the nerves are targeted by the first infection then the virus causes the targeting of the inside of the nerve....the cross targeting causes the autoimmune disease.
*this page is under construction and more references and OCD will be discussed soon.
Tics/OCD and strep
http://www.ncbi.nlm.nih.gov/pubmed/11466169
http://www.ncbi.nlm.nih.gov/pubmed/15241433
low levels of histamine, histamine gene, and genetic tourettes
http://www.scientificamerican.com/article/treating-tourettes/
Angela Biggs
Please see newer post: http://angelabiggs.blogspot.com/2015/02/over-view-of-brain-autoimmunity.html
I started to post how my cross-targeting theory applies to PANDAS, Tourettes, OCD and narcolepsy...and then I remembered Encephalitis Lethargica.
Before I start posting suspects and demonstrating the cross-targeting on the Basal Ganglia that I suspect I need to respectfully identify Dr. Andrew Church who works on Encephalitis Lethargia.
Everyone remembers the 1990 Awakenings movie with Robin Williams as Dr. Oliver who in 1918 dealt with an cluster of encephalitis lethargia patients. In 1993 Dr. Andrew Church found himself with another Encephalitis cluster and he discovered that 2 infections were there not just the flu. Dr. Andrew discovered that a high number of his patients had a rare form of strep called Diplococcus along with the spanish flu. He has spent a life time trying to piece together this disease.
In 2011 Dr. Andrew came out with this paper proving Encelpalitis lethargia was an autoimmune disease with antibodies directed at the Basal Ganglia. http://brain.oxfordjournals.org/content/127/1/21.full.pdf
Here today I am looking at the autoimmune diseases that cross-target on the Basal Ganglia. In this case the severity of the disease may depend on what mix you had causing the cross-targeting. My theory supports and validates his research.
Other Basal ganglia autoimmune diseases: http://qjmed.oxfordjournals.org/content/96/3/183.full
The NY cluster of LeRoy High PANDAS cluster. Dr. Trifiletti has also found 2 infections involved with this autoimmune disease which targets the Basal Ganglia. He has found Streptococcus pyogenes in 5 of the 8 girls and Mycoplasma pneumonia in 7 of the 8.
Parents of PANDA children have discovered their kids can relapse even after antibiotic recovery when their children receive a flu shot. I believe this is because the flu shot generates antibodies against the Basal Ganglia.
In England a cluster of children developed Narcolepsy which is a disorder of the basal ganglia after receiving a swine flu shot. The question is did they have another infection's antibodies there too? What infection broke the brain's blood barrier?
Update 6/29 History of strep was found in Narcolepsy patients
http://med.stanford.edu/psychiatry/narcolepsy/articles/ResponseToMarcusH1n1.pdf
Antibodies for strep found in narcolepsy patients
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717204/pdf/aasm.32.8.979.pdf
Tourettes has been associated not just with strep but with borrellia burgdorferi (lyme disease). Although I am about to show a connection with Lyme I think there exists a genetic disposition where only strep is required to develop the autoimmune reaction but this would be the kind of Tourettes that runs in families. (Rheumatic fever which is also an autoimmune reaction to strep has a genetic component and runs in my family....strep alone causes the autoimmune response of the joints etc)
Lyme and Tourettes:
http://www.ncbi.nlm.nih.gov/pubmed/15590039
http://www.tourette-gesellschaft.de/download/bts_lymedisease_muelleretal.pdf
http://www.ncbi.nlm.nih.gov/pubmed/9482302
Tourettes and lyme (this link added 2016)
http://abcnews.go.com/Health/girl-tics-bucks-doctors-blames-lyme-disease/story?id=19128125
My cross-targeting hypothesis is supported when one looks at the Basal Ganglia related autoimmune diseases. In order for autoimmune disease to develop 2 infections typically exist both causing the immune system to target the same thing.
Encephalitis lethargia: strep and spanish flu virus (H1N1 subtype not seen right now)
Tourettes: strep/ lyme's Borrellia and herpes ?
PANDAS/OCD: strep / mycobacteria and swine flu (common H1N1?)
Parkinson's: mycobacteria and avian flu virus
Cataplexy : strep and swine flu
Looking at this list Strep stands out. Strep definitely can get through or weaken the Blood Brain Barrier. http://blog.lib.umn.edu/nich0185/myblog/2011/10/the-blood-brain-barrier-and-ocd.html
http://nizetlab.ucsd.edu/publications/iaga-jci.pdf
The borriella of lyme disease drills a hole for itself through the barrier.
http://www.ncbi.nlm.nih.gov/pubmed/22355605
Mycobacteria weave their way through the barrier.
http://www.ncbi.nlm.nih.gov/pubmed/16586367
Once the protective barrier of the brain is down the antibodies seep through. All of these infections focus the immune system on the Basal Ganglia as a target but the mix you have could determine which disease you have?
Herpes and Tourettes references:
http://www.ncbi.nlm.nih.gov/pubmed/?term=herpes+virus+tourettes
http://www.ncbi.nlm.nih.gov/pubmed/3195682
http://www.autism.com/ari/newsletter/112/page2.pdf
http://www.ncbi.nlm.nih.gov/pubmed/18378549 (basal ganglia,herpes and movement)
Note that there are multiple types of swine flu and the CDC needs to start tracking which flu is associated with which autoimmune disease. (which swine flu etc since there are different ones)
The idea is: the outside of the nerves are targeted by the first infection then the virus causes the targeting of the inside of the nerve....the cross targeting causes the autoimmune disease.
*this page is under construction and more references and OCD will be discussed soon.
Tics/OCD and strep
http://www.ncbi.nlm.nih.gov/pubmed/11466169
http://www.ncbi.nlm.nih.gov/pubmed/15241433
low levels of histamine, histamine gene, and genetic tourettes
http://www.scientificamerican.com/article/treating-tourettes/
Angela Biggs
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