Saturday, June 8, 2013

Salt , autoimmune disease, and viruses


If we say that Cross-targeting must occur for Autoimmune disease to attack then how does salt fit in?


Cross-targeting is where the immune system attacks from Bcells looking for a visable infection like bacteria, fungus or mycoplasma and from a Tcell viral infection inside of cells. Two modes of attack focused on the same target.

Maybe salt increases the likelihood that cells are virus infected in the first place and attacked.   

Salt increases autoimmune disease:
http://www.huffingtonpost.com/2013/03/06/salt-autoimmune-disease-sodium-multiple-sclerosis-diabetes_n_2821200.html

Salt increases the amount of viruses absorbed by cells
http://www.jimmunol.org/content/61/1/65.abstract

Salt effects the immune system's tcells
http://www.ncbi.nlm.nih.gov/pubmed/23467095

Note that while Bcells are suppose to flag targets that are visible with antibodies Tcells go to HLA mailboxes expressed on all cells and check what is inside cells thus Tcells are responsible for finding viruses. 

Does salt increase the activation of HERVs? the old viruses that are are dormant merely buy favoring more virus infections? Further does salt increase the likelihood that t-cells would attack a herv activated cell?

I am just trying to fit this new piece of the puzzle into my current Hypothesis.

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