Tuesday, January 29, 2019

Contemplating Langerhans and marginal zone B cells: they appear to deliver the antigens to FDC

Do lymphatic Langerhans deliver antigens to the Germinal center Follicular Dendritic Cell like the marginal zone B cells in the spleen?

Marginal zone B cells shuttle antigens to FDC
https://www.ncbi.nlm.nih.gov/pubmed/18037889

Langerhans promotes the GC-B/Tfh formation during a leishmania infection
https://www.ncbi.nlm.nih.gov/pubmed/25070244

cd169 mediates the capture of exosomes in lymph and spleen
https://www.ncbi.nlm.nih.gov/pubmed/24255917

cd169 cells : Marginal zone B,  langerhans, scs, and MM
scs
https://www.ncbi.nlm.nih.gov/pubmed/22675532?dopt=Abstract
https://www.ncbi.nlm.nih.gov/pubmed/22192781?dopt=Abstract

If only langerhans and Marginal zone B cells interact with the FDC giving it antigens then what do they have in common? (langerhans at the lymph and MZB at the spleen)

marginal zone B cell cancer followed by langerhans cancer in 77 year old
https://www.ncbi.nlm.nih.gov/pubmed/26286813

langerhans histocytosis following lymphoma
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839484/

langerhans histocytosis resembling marginal zone lymphoma
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0714.2006.00436.x

epstein barr virus and marginal zone lymphoma
https://www.ncbi.nlm.nih.gov/pubmed/29228090
https://www.ncbi.nlm.nih.gov/pubmed/25692616
https://www.ncbi.nlm.nih.gov/pubmed/21552113

epstein barr is thought to bind cd21 but I believe it uses the estrogen alpha receptor

FDC and estrogen alpha receptor
https://ajp.amjpathol.org/article/S0002-9440(10)63490-6/pdf

estrogen promotes langerhans differentiation
https://www.ncbi.nlm.nih.gov/pubmed/16210618
https://www.researchgate.net/publication/7554414_Estrogen_Selectively_Promotes_the_Differentiation_of_Dendritic_Cells_with_Characteristics_of_Langerhans_Cells

estrogen favors marginal zone B cells
https://www.ncbi.nlm.nih.gov/pubmed/21107497

estrogen secreted by lymph tissue
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133356/
https://www.ncbi.nlm.nih.gov/pubmed/29486537

Benzene as the carcinogen: man who handled benzene developed marginal zone lymphoma
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605838/

alaska and benzene risk (thinking of my grandmother)
http://www.farnorthscience.com/2007/12/10/ak-sci-forum/benzene-exposure-in-anchorage/


Hypothesis Review:
alpha herpes use beta estrogen receptor hsv1 hsv2 zoster
beta herpes use estrogen related receptors cmz hhv6 hhv7
gamma herpes use alpha estrogen receptors EBV hhv8

marker for FDC is cd21
https://www.ncbi.nlm.nih.gov/pubmed/16280657






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