Thursday, January 17, 2019

How do B cells see the antigen for internal antigens? SCS macrophages are key



When you separate the inner and outer antigen pathways you can see where B cells become antigen presenters themselves but how do they see the antigens and make the proper antibody when the TCR of T cells are critical ?




In these scenarios we have left out the macrophages.  The SCS macrophages display viruses and antigens but macrophages are the "second stimulators".  They keep T cells activated and I believe they might also show the viral antigen to B cells that have been activated.



The macrophages are required for GC formation:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647009/

The SCS macrophages present the viral antigens to the BCR of B cells
https://www.cell.com/fulltext/S0092-8674(07)01401-8
https://www.ncbi.nlm.nih.gov/pubmed/17934446?dopt=Abstract (flypaper)
http://iannaconelab.com/wp-content/uploads/2011/03/Ann-NY-Acad-Sci-2014-Kuka.pdf

scs, viral infections, and Nk
http://www.bloodjournal.org/content/bloodjournal/120/24/4744.full.pdf?sso-checked=true

the 3 lymph node macrophages divided into 3 groups
https://www.karger.com/Article/FullText/337007?id=pmid:8050349

only dendritic cells presented to cd8  T cells (not the macrophages)
https://www.ncbi.nlm.nih.gov/pubmed/11828323/

memory B cells are reactivated by scs macophages
https://www.nature.com/articles/s41467-018-05772-7


SCS is the subcapular sinus macrophage

Marginal zone B cells shuttle antigens to FDC
https://www.ncbi.nlm.nih.gov/pubmed/18037889

Langerhans promotes the GC-B/Tfh formation during a leishmania infection
https://www.ncbi.nlm.nih.gov/pubmed/25070244

Possible that langerhans shuttles antigens like MZ B cells



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