Monday, September 25, 2017

Fluoxetine, Hepatitis C, MCR4, and eating disorders

Looking at the areas of overlap to reinforce the connection of Hep C with MS

Fluoxetine is a serotonin reuptake inhibitor
https://en.wikipedia.org/wiki/Fluoxetine

Fluoxetine and Hep C
http://forums.phoenixrising.me/index.php?threads/fluoxetine-antiviral-application.39225/

Fluoxetine and secondary progressive MS
https://www.msconnection.org/Blog/September-2016/Research-News-on-Secondary-Progressive-MS-from-ECT

Serotonin and MCR4 and appetite
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466475/

serotonin activates serotonin receptors which causes the secretion of alpha-MSH which triggers the MC4R

MC4R controls appetite and I had hypothesized that Hep C uses MCR4 receptors

Previous post on Hep C
http://angelabiggs.blogspot.com/2017/05/flaviviruses-melanocortin-receptors-and.html

Hep C and appetite disorders
https://www.ncbi.nlm.nih.gov/pubmed/22932161

Eating disorders in a sub population of MS
https://www.omicsonline.org/open-access/eating-disorders-in-a-multiple-sclerosis-clinical-population-and-its-associationwith-social-anxiety-2376-0389-1000183.php?aid=82623


antibodies to alpha-MSH and eating disorders (anorexia or bulimia)

http://psychnews.psychiatryonline.org/doi/10.1176/pn.38.1.0021

Note that Hep C would use the same receptor as alpha-MSH....the MCR4 receptor

Does the eating disorder appear and indicate MS that leads to Secondary progressive MS ?

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