Wednesday, May 10, 2017

Flaviviruses, Melanocortin receptors, and NK cells: Hepatitis C


Hepatitis C and NK cell dysfunction
https://www.hindawi.com/journals/bmri/2014/903764/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817297/
https://www.ncbi.nlm.nih.gov/pubmed/16234066

When you consider the autosomal recessive disorder Griscelli syndrome and interesting overlap appears.

Griscelli syndrome is the appearance of silver gray hair starting in infancy and hypo-pigmentation diagnosed as partial albinism.  Griscelli syndrome appears to be a genetic disorder where there is disrupted transport of melanosomes, melanin pigment containing vesicles.  What is fascinating about this is that Griscelli syndrome is also associated with neutropenia, thrombocytopenia, and NK cell dysfunction.

Hepatitis C has been connected to thrombocytopenia
https://jmedicalcasereports.biomedcentral.com/articles/10.1186/1752-1947-8-303
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333732/
https://www.ncbi.nlm.nih.gov/pubmed/21188328
https://www.ncbi.nlm.nih.gov/pubmed/19154665

Hepatitis C has been connected to neutropenia
http://journals.lww.com/co-hematology/Abstract/2014/01000/Hepatitis_C_and_neutropenia.11.aspx
https://academic.oup.com/cid/article/doi/10.1086/376971/331606/Hematologic-Disorders-Associated-with-Hepatitis-C
http://hepatitis.cl/wp-content/uploads/2012/08/2002-1-Neutropenia-associated-with-alpha-interferon-therapy-of-chronic-hepatitis-C.pdf

I have been dividing up the flaviviruses with the melanocortin receptor they could use:

mcr1   Tick borne encephalitis virus/ hepatitis C   (Thrombocytopenia due to red blood cells with mcr1)

mcr2 (ACTH receptor)   Zika (placenta, developing brain)

mcr3  West nile (kidneys)

mcr3 and mcr1  Japanese encephalitis

mcr4  Yellow fever (liver)/ hepatitis C
                        
mcr5  Dengue (immune system T cells)


NK cells and Tickborne encephalitis virus
http://www.jimmunol.org/content/early/2016/08/19/jimmunol.1600950.short

MCR1 and melanosome
http://www.jimmunol.org/content/early/2016/08/19/jimmunol.1600950.short







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