Wednesday, August 16, 2017

Suramin, Zika virus, and the ACTH receptor

The Zika virus looks as if it binds the ACTH receptor.

I have been dividing up the flaviviruses with the melanocortin receptor they could use:

mcr1   Tick borne encephalitis virus/ hepatitis C   (Thrombocytopenia due to red blood cells with mcr1)

mcr2 (ACTH receptor)   Zika (placenta, developing brain)

mcr3  West nile (kidneys)

mcr3 and mcr1  Japanese encephalitis

mcr4  Yellow fever (liver)/ hepatitis C
                        
mcr5  Dengue (immune system T cells)


Previous posts of Zika and ACTH receptors
http://angelabiggs.blogspot.com/2017/07/zika-malaria-drugs-and-acth-receptor.html

Suramin blocks Zika infection by binding were the virus attaches
https://www.ncbi.nlm.nih.gov/pubmed/28457855
https://www.ncbi.nlm.nih.gov/pubmed/28461070

Suramin binds the ACTH molecule
https://www.ncbi.nlm.nih.gov/pubmed/2152879

So is suramin binding the virus as if it is an ACTH molecule? Does this support the hypothesis that Zika uses ACTH receptors?

note that suramin is a drug that kills parasites and is used against the sleeping sickness and has been found to find to do other actions....but here with Zika it interferes with viral attachment

Previous post linking virus families to receptor families
http://angelabiggs.blogspot.com/2017/06/updated-virus-families-bind-and-enter.html

No comments:

Post a Comment