Malaria drug protects against Zika infection
https://medicine.wustl.edu/news/malaria-drug-protects-fetuses-from-zika-infection/
This malaria drug is hydroxychloroquine.
Chloroquine causes an ACTH dump
https://www.ncbi.nlm.nih.gov/pubmed/6300682
Placenta is the origin of ACTH in pregnancy
https://www.nature.com/nature/journal/v254/n5501/abs/254620b0.html
ACTH could compete with the Zika virus for the ACTH receptor. Thus the protection by chloroquine could be by increasing the amount of ACTH.
Zika and ACTH receptors
http://angelabiggs.blogspot.com/2017/05/zika-acth-receptors-and-muscle-tightness.html
http://angelabiggs.blogspot.com/2017/06/updated-virus-families-bind-and-enter.html
Zika virus causes "old man syndrome" on the second day of the infection be due to the muscle tightness? (my sister had Zika in Mexico and this is what she described happened on day 2)
My sister also mentioned that her feet felt like they were burning.
taking supplemental ACTH for "Cushing disease" can cause the burning sensation and a gait to the walk
http://www.ehealthme.com/ds/acth/burning-sensation/
For infants with zika virus they have seen increased pigment in the eyes
http://www.nbcnews.com/storyline/zika-virus-outbreak/babies-zika-linked-birth-defects-may-have-eye-trouble-too-n514876
High ACTH given to Zebra fish caused pigment a similar pigment increase.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365489/
No comments:
Post a Comment