Friday, July 7, 2017

Does HPV5 use the Cannabinoid 2 receptor?

HPV5 and squamous skin cancer
http://onlinelibrary.wiley.com/doi/10.1111/j.1468-3083.2010.03713.x/abstract

squamous skin cancer over expresses CB2 receptors
https://www.ncbi.nlm.nih.gov/pubmed/20335147

which means that HPV5 uses the  CB2 receptor or CB1?

there is a bit of confusion because I had squamous linked to CB1 and basal linked to CB2

HPV16 for squamous and HPV18 for adenocarcinoma (basal cell)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361088/

Previous post on HPV and Cannabinoid receptors
http://angelabiggs.blogspot.com/2016/08/cannabinoid-receptors-and-human.html

hpv16 and squamous (head and neck cancers)
http://clincancerres.aacrjournals.org/content/8/10/3187

CB2 receptor and head and neck
https://www.ncbi.nlm.nih.gov/pubmed/23601830

squamous clear cell carcinoma
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687164/

Co-carcinogenesis hypothesis (Francis Peyton Rous) a virus and a carcinogen together cause cancer.

 My expansion on the hypothesis: It must be a nuclear virus.  (not all viruses enter the nucleus) The carcinogen and virus must be in the same cell's nucleus.  The receptor used by the virus to enter gives characteristics to the cancer. The triggered pathways are over expressed.

Cannabinoid one receptor and pancreatic cancer
http://www.ejcancer.com/article/S0959-8049(08)00810-1/pdf

HPV18 and pancreatic cancer
https://www.sciencedaily.com/releases/2012/07/120731151739.htm

so I might have had the HPV16 &18 viruses and cannabinoid receptors flipped

HPV18 : cb1 : basal cancer
HPV16: cb2: squamous

HPV18 and HPV16 with asbestos
https://www.ncbi.nlm.nih.gov/pubmed/24494324

Most breast cancer was asbestos chrysotile with HPV16

 "HPV-16 always co-exists with increased Chrysotile Asbestos deposits, and the outline of the breast cancer positive area is a relatively smooth and round or oval shape, and breast cancer with HPV-18 always co-exists with increased Tremolite Asbestos"

Most triple negative breast cancer are round and oval shaped
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538191/





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