Suicide, t.gondii tails, profolin, and the cytoskeleton

The suicidal tendencies of those infected with T.gondii could be caused by the parasite building it's flaggellum or tail from actin.

 T. gondii and suicide attempts in Denmark mothers
https://www.ncbi.nlm.nih.gov/pubmed/22752117

T. gondii and suicide
https://www.ncbi.nlm.nih.gov/pubmed/20010026

TLRs and t.gondii
http://www.nature.com/nri/journal/v14/n2/fig_tab/nri3598_F1.html

TLR11 binds profolin of T.gondii (a protein that polymerizes actin during the formation of tails)
https://www.ncbi.nlm.nih.gov/pubmed/18312842

There is a brain-derived-factor connected to suicide which is known to bind tropomyosin-related kinase B (TrkB)
http://www.hdbp.org/psychiatria_danubina/pdf/dnb_vol25_sup2/dnb_vol25_sup2_341.pdf

Tropomyosin is an actin binding regulator of the cytoskeleton
https://www.ncbi.nlm.nih.gov/pubmed/26315888

Could profolin like the brain-derived-factor disrupt the tropomyosin?

The brains of suicide : disrupted cytoskeletons
https://www.researchgate.net/figure/234000212_fig3_Figure-3-The-protein-network-of-altered-cytoskeleton-proteins-in-the-brains-of-suicide


Tangent thoughts about T.gondii

T.gondii's infect macrophages and cause TNF to be released

Host cells's ER is used by T.gondii
https://www.ncbi.nlm.nih.gov/pubmed/9248995

T.gondii induces apoptosis via ER stress pathway
https://www.ncbi.nlm.nih.gov/pubmed/24612639

Dysfunction of the ER causes the IFNgamma to be expressed