Toll like receptors

TLRs toll like receptors: receptors that aid the immune system by binding groups of MOLECULES (larger regions than antigens) to identify pathogens.  The "nets" catch commonly conserved pathogen features.

Image of TLRS
https://pdb101.rcsb.org/motm/143

toll like receptors pathways
https://www.cellsignal.com/contents/science-pathway-research-immunology-and-inflammation/toll-like-receptors-(tlrs)-pathway/pathways-tlr

toll like receptors recognize microbes
https://www.ncbi.nlm.nih.gov/pubmed/15033189

TLR3 and west nile infection
https://www.ncbi.nlm.nih.gov/pubmed/15558055

west nile induces calcium influx
http://jvi.asm.org/content/84/17/8721.full

TLR 3 and viral infections
http://cmr.asm.org/content/21/1/13.full

TLR3 also binds double stranded RNA like retroviruses

TLR5 binds bacterial flagellin
http://www.jbc.org/content/285/16/12149.full

TLR1 binds peptidoglycan
https://en.wikipedia.org/wiki/TLR_1

TLRs and parkinson's: TLR2 and TLR4
https://www.ncbi.nlm.nih.gov/pubmed/25522431

TLR2 binds modulins
https://www.ncbi.nlm.nih.gov/pubmed/20817012

modulins are microbial virulence factors that alter the hosts cytokines

TLR4 binds lipopolysaccharide 
https://en.wikipedia.org/wiki/TLR4

TLR2 and TLR4 have been connected to Mycobacterias
https://www.ncbi.nlm.nih.gov/pubmed/19919859

Mycobacterias have been linked to parkinson's through nocardia, tuberculosis, and psoriasis which means the connection of the TLR2 and TLR4 in parkinson's could be to the mycobacterias

note that lots of infections are also connected to TLR2 and TLR4