TLRs and Type one diabetes

Autoimmune hypothesis: 2 infections on one target like the pancreas triggers autoimmunity by cross-targeting the inside and the outside at the same time. One infection inside and one infection outside.

Example for type one diabetes: E.coli cross-targeting with the flu...but there are other combinations.

TLRs in mice with diabetes tlr 1, 2, 3, and 7
https://www.ncbi.nlm.nih.gov/pubmed/19199942

TLR7 would be nuclear
TLR3 would be cytosol

TLR1 peptidoglycan (found on almost all bacterias and yeasts)
TLR2 modulins (compounds bacterias use to alter or  modulate our cells cytokine messages)

E.coli, sutterella, and yeasts as the large infections could be TLR1 and TLR2.

e.coli and TLR1 and TLR2
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869100/

Toll like receptor 3 and diabetes : coxsackie
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298321/

toll like receptor 3 and diabetes
https://www.ncbi.nlm.nih.gov/pubmed/25926108

tlr3 and flu in mice
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.0020053

Flu goes into the cytosol then into the nucleus
http://www.virology.ws/2009/05/06/release-of-influenza-viral-rnas-into-cells/