Wednesday, September 9, 2015

Patterns found concerning breast cancer while looking for autoimmune patterns:support for the Cancer Potentiation hypothesis called Co-carcinogenesis

Although this is an autoimmune blog I have noticed a few patterns concerning cancer and I have a few thoughts.

As I was pairing receptors up with the viruses that might be using them I noticed that cancers had receptor patterns.   Breast cancer has an"estrogen receptor" increased type.  I began to wonder if the virus involved in causing the cancer left it's mark in the form of expressed receptors. Could this form be connected to a herpes virus which I had connected to the estrogen receptor?  A breast cancer started by a type of herpes would express an increased number of estrogen receptors?

Herpes and estrogen receptors
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798450/

In nerves estrogen receptors cycle to the mitochondria which would explain how herpes hides there
http://www.pnas.org/content/101/12/4130.full.pdf

Ten percent of breast cancer metastasized to the bone. An area that herpes does not move to but that other viruses can....like HPV? Does the virus have an involvement with the metastasizing ?

HPV bone marrow
http://link.springer.com/article/10.1007%2FBF02257961#page-1

Viruses and breast cancer: epstein barr and HPV

HPV and breast cancer

Does the metastasizing patterns of cancers match the viral infection patterns?

One can have a virus that can trigger cancer and not develop the cancer. One can be exposed to a carcinogen and not develop can cancer. Hypothesis for cancer: is it the combination of a carcinogen and a virus that triggers cancer?

Herpes virus simplex 2 and Benzene together transformed regular cells into cancer 1982 paper
http://www.ncbi.nlm.nih.gov/pubmed/6293737

This Cancer potentiation hypothesis was called Co-carcinogenesis
http://www.nature.com/onc/journal/v23/n38/full/1207822a.html

Which carcinogens pair up with breast cancer ? obviously smoking could trigger it but can any carcinogen could push a virus infected cell into the oncogenic state?

HPV and cervical cancer has which receptor increased? Cannabinoid?
HPV infects the lung, the breast....can we see metastasizing patterns? there should be a higher rate of coexisting breast and cervical cancer if HPV is involved.



Looking at pancreatic cancer which is infected by the flu virus and coxsackie. Do we see the same pattern?

coxsackie and pancreatic cancer
http://www.ncbi.nlm.nih.gov/pubmed/1193416

Nicotine receptors increases with pancreatic cancer is this caused by the coxsackie virus?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832917/

Are D2 dopamine receptors are increased in pancreatic tumors by the flu virus?
http://press.endocrine.org/doi/full/10.1210/jc.2003-031039
http://www.ncbi.nlm.nih.gov/pubmed/11174837?dopt=Abstract

Benzene and pancreatic cancer
http://www.ncbi.nlm.nih.gov/pubmed/26293241

How does Benzene amplify the effect of a virus to become carcinogenic?
Benzene inhibits the polymerase?
http://www.ncbi.nlm.nih.gov/pubmed/2926830

 Benzene inhibits replication while viruses turn on replication. Benzene inhibits polymerases but viruses supply their own polymerases. Has the benzene inhibited the viral polymerase?

viruses are now being found to alter the telomeres, the ends of chromosomes, which typically limit the number of times of division.
http://www.cell.com/cell-reports/pdf/S2211-1247(14)00973-5.pdf

So is it unlimited replication set up by the virus in the host cell but now the viral polymerases are inhibited by benzene which leaves our cells functioning but out of control?

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