ALS and cross-targeting autoimmunity

ALS: Is the spontaneous form triggered by cross-targeting?

link to newer over view post
http://angelabiggs.blogspot.com/2015/02/over-view-of-brain-autoimmunity.html

Hypothesis: Cross-targeting autoimmunity occurs when 2 infections, one being a virus, infect the same target.  (or generate antibodies against the same target) This state causes the immune system to escalate the immune attack into autoimmunity because both the inside and the outside of the organ is marked as infected.

ALS is an autoimmune disease where 60% of spontaneous cases have antibodies against calcium channels.

http://www.ncbi.nlm.nih.gov/pubmed/8109897
http://www.ncbi.nlm.nih.gov/pubmed/1331790
http://www.ncbi.nlm.nih.gov/pubmed/7818241

Previously I looked at ALS, picks disease, and trichophyton.
 http://angelabiggs.blogspot.com/2013/09/picks-disease-and-als-and-blastomyces.html

Trichophyton is a type of blastomyces which when it infects dogs they are identified by an increase in blood calcium levels.  Is this true for people? Do calcium levels go up? http://www.dermatologyforanimals.com/faq-07/

Blastomyces are a type of fungal infection that can survive without iron as long as it has high calcium available.

Why am I looking at Trichophyton as a trigger for ALS? It is a fungal infection associated with athletes foot and it is involved with the decomposing of rotting wood and exists in high levels around the great lakes which has several ALS clusters.  Blastomyces has a high affinity for high calcium so I am looking at the EF hands involved with the calcium channels and how Trichophton grabs calcium. Is there a connection here?

The key here is that I must find a virus that infects the same neurons that the calcium channels have been marked on....specifically the neurons that are attacked in als.

Review of viruses indicates herv-k
http://www.ncbi.nlm.nih.gov/pubmed/23707220
the problem is we don't know what awakens herv

note that drinking coffee seems to lower the chances of ALS
http://aje.oxfordjournals.org/content/early/2011/10/18/aje.kwr229.full

Caffeine seems to inhibit DNA repair and inhibits retroviruses like HIV and Herv
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC546572/

Both HIV and herv have been associated with ALS

HIV and ALS like syndromes
http://www.ncbi.nlm.nih.gov/pubmed/2561585
http://www.ncbi.nlm.nih.gov/pubmed/24842949
http://www.ncbi.nlm.nih.gov/pubmed/23931799

Herv reactivation notions: are bacterial infections involved?
http://www.nature.com/nature/journal/v491/n7426/abs/nature11599.html 

Now looking into Felines (cats) , retroviruses, and Blastomyces
http://books.google.com/books?id=RrSvvcWLpmgC&pg=PT213&lpg=PT213&dq=blastomycosis++feline+retrovirus&source=bl&ots=GUHcbNorBA&sig=wUE0BaB36l1lwlq7llysQfOe158&hl=en&sa=X&ei=kdADVLcawsCCBJKsgfgJ&ved=0CC4Q6AEwAQ#v=onepage&q=blastomycosis%20%20feline%20retrovirus&f=false


WOW....in the past i looked at t.gondii and herv because schizophernia has high levels of herv involved: i just found this article
http://www.ncbi.nlm.nih.gov/pubmed/17054075   (we need to look at blastomyces more when it comes to herv)

Here is my older post:http://angelabiggs.blogspot.com/2013/05/lou-gehrigs-disease-and.html