neuromyelitis optica and cross-targeting autoimmunity

Neuromyelitis optica (Devic's disease) is a demyelinating disease of the central nervous system that preferentially affects the optic nerve and spinal cord. Once thought to be a type of MS but now considered a separate disease.

Hypothesis: Cross-targeting autoimmunity occurs when 2 infections, one being a virus, infect the same target.  This state causes the immune system to escalate the immune attack into autoimmunity because both the inside and the outside of the organ is marked as infected.

culprits for neuromyelitis optica : influenza A and candida or influenza and mycoplasmas?

influenza A and neuromyelitisoptica
http://www.ncbi.nlm.nih.gov/pubmed/21804290
This could explain the narcolepsy group
http://www.ncbi.nlm.nih.gov/pubmed/22777080
Flu vaccine and narcolepsy
http://www.ncbi.nlm.nih.gov/pubmed/24849861
Narcolepsy and candida
http://www.ncbi.nlm.nih.gov/pubmed/?term=candida+narcolepsy
Narcolepsy and hypocretin neurons
http://healthysleep.med.harvard.edu/narcolepsy/what-is-narcolepsy/science-of-narcolepsy

does strep cause the narcolepsy version?
http://www.aasmnet.org/jcsm/ViewAbstract.aspx?pid=28864
by letting the antibodies across against mycoplamsas or fungus? 2 autoimmune diseases together?


Candida? Sjogren connection to neuromyelitisoptica
http://www.ncbi.nlm.nih.gov/pubmed/20235486
http://www.ncbi.nlm.nih.gov/pubmed/20120352
I am currently looking at other fungal infections that are known to grow along the the spine

Older post of mine with Candida, sjogren, Hashimotos
http://angelabiggs.blogspot.com/2013/08/aspergers-sjogren-and-hosimotos-overlap.html 

Second culprit: Mycoplasma, lupus,but still the flu virus

neuromyelitisoptica  and lupus
http://www.ncbi.nlm.nih.gov/pubmed/24948869
http://www.ncbi.nlm.nih.gov/pubmed/19745613

neuromyelitisoptica  and mycoplasmas
http://www.ncbi.nlm.nih.gov/pubmed/24557856
http://www.ncbi.nlm.nih.gov/pubmed/19497587
http://www.ncbi.nlm.nih.gov/pubmed/18563469

MY older post of lupus/RA and mycoplasmas
http://angelabiggs.blogspot.com/2013/04/lupus-and-ra-leukemia-and-mycoplasmas.html

 What are the other considerations:

Asian multiple sclerosis is actually neuromyelitisoptica not MS
http://www.ncbi.nlm.nih.gov/pubmed/18990121 
http://www.ncbi.nlm.nih.gov/pubmed/21962794


The overlap of lupus and sjogren's must be addressed.  Both conditions have anti-phospolipids which I previously suggested had to do with these infections using high levels of biofilms to stick them onto the phospholipid bilayer. Mycoplasmas as the smallest type of infection and fungal as the largest.
I had surmised that the immune system releases extra phospholipids in an attempt to get these off the cell walls.  http://angelabiggs.blogspot.com/2013/12/antiphospholipids-and-infections-with.html

Extra phospholipids may not only cause anti-phospholipid antibodies but the lipids could be triggering water channels.  here is an indirect example of a water channel altered by lipids: http://www.ncbi.nlm.nih.gov/pubmed/23680159

A bit of an extrapolation but what if the lipids used by the immune system messed up the water channels of the infection and made them visible to the immune system?

Aquaporin 4 in sensory neurons
http://chemse.oxfordjournals.org/content/33/5/481.full.pdf

Anti-aquaporin in neuromyelitisoptica
http://www.ncbi.nlm.nih.gov/pubmed/25160125

Aquaporin 4 cross-immunoreactivity with aquaporin Z
http://www.ncbi.nlm.nih.gov/pubmed/23008451

which infections have aquaporin Z? candida does have one but not Z....same for a mycoplasma
http://www.medizin.uni-greifswald.de/funkgenom/teaching/100114-V12-1-Osmosensing-Lit/Tanghe%20et%20al.%202006-Trends%20Microbiol.pdf
does the aquaporin they have cross-immunoreact?

interesting article: mycoplasma, NMO, and anti-aquaporin 
http://www.ncbi.nlm.nih.gov/pubmed/194975

my gut is telling me there exists a  connection between the phospholipids and the aquaporins...the biofilms?

Looking at the water channels of biofilms
http://www.ncbi.nlm.nih.gov/pubmed/23271809

HERE IT IS: aquaporins help to form biofilms is addressed in this book!
http://www.sciencedirect.com/science/journal/03044165/1840/5   

Summary: mycoplasmas or fungal infections make an obscene amount of biofilm which our immune system develops antibodies to.  (anti-aquaporin is produced because they would stand out in the biofilm ) anti-aquaporins would target our cells with aquaporin4 but autoimmunity would only occur when a virus infects these specific cells with aquaporin4.  The immune system has cross-targeted the cell....antibody marking the outside and virus marking the inside driving the autoimmunity to begin.

good hypothesis but not proven