Alzheimer's I have been viewing as a mitochondrial disease where the nerve gets stuck in growth mode attempting to call mitochondria down the nerves axon. Mothers of down syndrome children tend to get the early form of Alzheimer's disease. Down syndrome is caused by malfunctioning mitochondria not making enough ATP for dividing the chromosomes correctly. Without decent ATP levels the mitochondria do not move correctly.
The herpes virus (cold sore) has recently been discovered to cause mitochondrial dysfunction. The mitochondria do not move where they are suppose to. In 2011 the herpes virus was associated with Alzheimer's disease. Infecting the neurons in question.
ref
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1796774/
http://www.sciencedaily.com/releases/2011/04/110404122203.htm
So the question is: How did the virus get past the blood brain barrier? Everyone with cold sore herpes does not have dementia.
Type 2 diabetes has been associated with Alzheimer's disease. I have postulated that some type 2 diabetes maybe caused by mycobacterias. So perhaps a mycobacteria has broken the blood brain barrier. Something must be involved in breaking the BBB like strep or t.gondi or a mycobacteria in order for the herpes virus to get into the brain.
Mycobacteria has been debated: http://www.ncbi.nlm.nih.gov/pubmed/10426143
Parkinson's I have associated with mycobacteria and avian flu/flaviviruses possibly causing an autoimmune disease by cross-targeting. Do Parkinson's patients who develop Alzheimer's have the herpes virus on top? The mycobacteria breaking the BBB allowing both viruses to sneak through a hole for both diseases?
Tourettes I was considering strep followed by a herpes virus. I am reconsidering now. Do all Tourettes patients develop Alzheimer's ? Strep breaks the blood barrier. This does not make sense because Tourettes patients tend to have enhanced memory skills. Is alzheimer's only caused by mycobacteria because strep rarely is infecting a patient long enough to allow herpes across and when it does tourettes results instead?
reference of Strep in brains cells and autoimmunity to brain cells in Tourettes or is this Pandas?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1174655/
reference of herpes and Tourettes
http://www.ncbi.nlm.nih.gov/pubmed/3195682
Must mycobacteria be involve with the herpes virus for Alzheimer's to develop? Tourettes with just strep and herpes infections will only have the autoimmune triggered tics? Or is tourettes so genetic that it only needs strep? you would think the herpes could cross over and do damage causing Alzheimer's which we do not see.....Tourettes patients tend to have brilliant memories.
2015 update Tourettes is Genetic while pandas which is tourettes like is autoimmune? http://angelabiggs.blogspot.com/2015/02/over-view-of-brain-autoimmunity.html
Cross-targeting means:
A first infection marks a target with antibodies on the outside and then a virus marks the inside of a target to the immune system. Hypothesis is that cross-targeting triggers autoimmune disease.
I believe that Alzheimer's is not an autoimmune disease rather a mitochondria dysfunction while parkinson's and Pandas are autoimmune. Maybe?
Could this overlap of infectious culprits explain some of the overlap we see in some patients with Alzheimer's disease? Could herpes be destroying the mitochondria of some elderly causing some cases of Alzheimer's but the patients can later develop parkinson's because it was a mycobacteria the opened the blood brain barrier? This means there is no order to Parkinson's or Alzheimer's concerning mycobacteria. one could even get parkinson's first?
Where syn and amyloid plaques appear together mycobacteria exists? With Parkinson's as an autoimmune disease of cross-targeting between a mycobacteria and avian flu/west nile? Can we get syn build up before the autoimmunity? before the parkinson's even if just mycobacteria is there?
Do mothers of down syndrome children have the amyloid plaques? When are the plaques not there? Are they a sign the mitochondria can't move and all Alzheimer patients will have some? But the dementia is really the inability of the mitochondria to move? Obviously their mitochondria has malfunction and herpes did not have to be involved. Again Alzheimer's would be a mitochondria moving disease.
Can the t.gondi of schizophrenia allow the herpes virus across? Notice a theme of larger infections creating the holes allowing viruses to slip through.
I will research this and post references soon. This page is still under construction. (it is a tad confusing at the moment )
Other things that need to be tied in: the diacetyl link to Alzheimer's disease. Used as the artificial butter in popcorn and margarine it is also the undesirable butterscotch taste in beer. The mitochondria of S. cerevisiae make diacetyl during the early stages of fermentation. My suspicion is that since it comes from a mitochondria....it will interfere in high levels with the function of mitochondria in some kind of negative feedback loop. Thus the popcorn and alcohol dementia are caused by malfunction mitochondrias not moving? I really hope this is not true. I can't give up my quality beer or wine....honestly i might choose some mental loss later. Or at least hope that it is really just when overdoses and drinking in moderation is fine....we can hope. My bet is that extremely high doses are required. That or i have to switch to Red Wine.
diacetyl in popcorn and Alzheimer's
http://www.cbsnews.com/8301-504763_162-57489905-10391704/diacetyl-chemical-in-artificial-butter-popcorn-linked-to-alzheimers-plaque-build-up/
So what might be true...herpes with mycobacteria cause mitochondria dysfunction but alone they may not? Or is it that Tourettes is only a genetic attack on the basal ganglia once strep has broken the barrier regardless of herpes....and herpes only makes things worse later for the Tourettes patient. And herpes just needs to cross the blood brain barrier (a hole made by any of the infections that can ) in order to cause the mitochondria to malfunction.....maybe?
Schizophrenia which could be an autoimmune attack caused by t.gondi breaking the blood brain barrier has had issues with dementia. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1737362
Could these be the patients with the herpes (cold sore) viruses?
update herpes and schizophrenia
http://www.ncbi.nlm.nih.gov/pubmed/15319094
Anyone else have thoughts on this? Is this possible?
The herpes virus (cold sore) has recently been discovered to cause mitochondrial dysfunction. The mitochondria do not move where they are suppose to. In 2011 the herpes virus was associated with Alzheimer's disease. Infecting the neurons in question.
ref
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1796774/
http://www.sciencedaily.com/releases/2011/04/110404122203.htm
So the question is: How did the virus get past the blood brain barrier? Everyone with cold sore herpes does not have dementia.
Type 2 diabetes has been associated with Alzheimer's disease. I have postulated that some type 2 diabetes maybe caused by mycobacterias. So perhaps a mycobacteria has broken the blood brain barrier. Something must be involved in breaking the BBB like strep or t.gondi or a mycobacteria in order for the herpes virus to get into the brain.
Mycobacteria has been debated: http://www.ncbi.nlm.nih.gov/pubmed/10426143
Parkinson's I have associated with mycobacteria and avian flu/flaviviruses possibly causing an autoimmune disease by cross-targeting. Do Parkinson's patients who develop Alzheimer's have the herpes virus on top? The mycobacteria breaking the BBB allowing both viruses to sneak through a hole for both diseases?
Tourettes I was considering strep followed by a herpes virus. I am reconsidering now. Do all Tourettes patients develop Alzheimer's ? Strep breaks the blood barrier. This does not make sense because Tourettes patients tend to have enhanced memory skills. Is alzheimer's only caused by mycobacteria because strep rarely is infecting a patient long enough to allow herpes across and when it does tourettes results instead?
reference of Strep in brains cells and autoimmunity to brain cells in Tourettes or is this Pandas?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1174655/
reference of herpes and Tourettes
http://www.ncbi.nlm.nih.gov/pubmed/3195682
Must mycobacteria be involve with the herpes virus for Alzheimer's to develop? Tourettes with just strep and herpes infections will only have the autoimmune triggered tics? Or is tourettes so genetic that it only needs strep? you would think the herpes could cross over and do damage causing Alzheimer's which we do not see.....Tourettes patients tend to have brilliant memories.
2015 update Tourettes is Genetic while pandas which is tourettes like is autoimmune? http://angelabiggs.blogspot.com/2015/02/over-view-of-brain-autoimmunity.html
Cross-targeting means:
A first infection marks a target with antibodies on the outside and then a virus marks the inside of a target to the immune system. Hypothesis is that cross-targeting triggers autoimmune disease.
I believe that Alzheimer's is not an autoimmune disease rather a mitochondria dysfunction while parkinson's and Pandas are autoimmune. Maybe?
Could this overlap of infectious culprits explain some of the overlap we see in some patients with Alzheimer's disease? Could herpes be destroying the mitochondria of some elderly causing some cases of Alzheimer's but the patients can later develop parkinson's because it was a mycobacteria the opened the blood brain barrier? This means there is no order to Parkinson's or Alzheimer's concerning mycobacteria. one could even get parkinson's first?
Where syn and amyloid plaques appear together mycobacteria exists? With Parkinson's as an autoimmune disease of cross-targeting between a mycobacteria and avian flu/west nile? Can we get syn build up before the autoimmunity? before the parkinson's even if just mycobacteria is there?
Do mothers of down syndrome children have the amyloid plaques? When are the plaques not there? Are they a sign the mitochondria can't move and all Alzheimer patients will have some? But the dementia is really the inability of the mitochondria to move? Obviously their mitochondria has malfunction and herpes did not have to be involved. Again Alzheimer's would be a mitochondria moving disease.
Can the t.gondi of schizophrenia allow the herpes virus across? Notice a theme of larger infections creating the holes allowing viruses to slip through.
I will research this and post references soon. This page is still under construction. (it is a tad confusing at the moment )
Other things that need to be tied in: the diacetyl link to Alzheimer's disease. Used as the artificial butter in popcorn and margarine it is also the undesirable butterscotch taste in beer. The mitochondria of S. cerevisiae make diacetyl during the early stages of fermentation. My suspicion is that since it comes from a mitochondria....it will interfere in high levels with the function of mitochondria in some kind of negative feedback loop. Thus the popcorn and alcohol dementia are caused by malfunction mitochondrias not moving? I really hope this is not true. I can't give up my quality beer or wine....honestly i might choose some mental loss later. Or at least hope that it is really just when overdoses and drinking in moderation is fine....we can hope. My bet is that extremely high doses are required. That or i have to switch to Red Wine.
diacetyl in popcorn and Alzheimer's
http://www.cbsnews.com/8301-504763_162-57489905-10391704/diacetyl-chemical-in-artificial-butter-popcorn-linked-to-alzheimers-plaque-build-up/
So what might be true...herpes with mycobacteria cause mitochondria dysfunction but alone they may not? Or is it that Tourettes is only a genetic attack on the basal ganglia once strep has broken the barrier regardless of herpes....and herpes only makes things worse later for the Tourettes patient. And herpes just needs to cross the blood brain barrier (a hole made by any of the infections that can ) in order to cause the mitochondria to malfunction.....maybe?
Schizophrenia which could be an autoimmune attack caused by t.gondi breaking the blood brain barrier has had issues with dementia. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1737362
Could these be the patients with the herpes (cold sore) viruses?
update herpes and schizophrenia
http://www.ncbi.nlm.nih.gov/pubmed/15319094
Anyone else have thoughts on this? Is this possible?
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