Nodding disease is triggered by the parasitic worm and what virus? The IgG4 was found against leiomodin-1. Nodding disease is autoimmune disease of the skin where the autoantigen attacks the brain?
Onchocerca volvulus causing epilepsy or nodding disease?
http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0002147
https://www.npr.org/sections/goatsandsoda/2017/02/15/515424720/scientists-may-have-solved-the-mystery-of-nodding-syndrome
autoimmune cross-targeting hypothesis: two infections on one tissue. The skin?
For these worms how does this work? The Leiomodin-1 autoantibody bound the worms.
When exposed to cold temperatures or food the children nod their heads uncontrollably. The hippocampus of the brain is responsible for body temperature sensations and hunger urges.
The worm is not in the hippocampus but the autoantibody shows up there.
https://www.ncbi.nlm.nih.gov/pubmed/28202777
Which virus at the skin has co-infected and caused the IgG4? Maybe HSV1?
HSV1 in africa
350 million women
355 million men
https://www.who.int/news-room/detail/28-10-2015-globally-an-estimated-two-thirds-of-the-population-under-50-are-infected-with-herpes-simplex-virus-type-1
HSV1 in small children who suck on their fingers causes the infection of fingers "herpetic whitlow"
Nodding disease only affects children under the age of 15. Is this because adults don't typically develop HSV1 outside of the mouth?
could it be molluscum contagiosum?
https://idpjournal.biomedcentral.com/articles/10.1186/s40249-018-0450-3
hippocampus and body temp
http://www.jneurosci.org/content/27/7/1566
Febrile seizures and enteroviruses???
https://www.ncbi.nlm.nih.gov/pubmed/11134476
febrile seizure that lasts more than ten minutes is complex
Onchocerca volvulus causing epilepsy or nodding disease?
http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0002147
https://www.npr.org/sections/goatsandsoda/2017/02/15/515424720/scientists-may-have-solved-the-mystery-of-nodding-syndrome
autoimmune cross-targeting hypothesis: two infections on one tissue. The skin?
For these worms how does this work? The Leiomodin-1 autoantibody bound the worms.
When exposed to cold temperatures or food the children nod their heads uncontrollably. The hippocampus of the brain is responsible for body temperature sensations and hunger urges.
The worm is not in the hippocampus but the autoantibody shows up there.
https://www.ncbi.nlm.nih.gov/pubmed/28202777
Which virus at the skin has co-infected and caused the IgG4? Maybe HSV1?
HSV1 in africa
350 million women
355 million men
https://www.who.int/news-room/detail/28-10-2015-globally-an-estimated-two-thirds-of-the-population-under-50-are-infected-with-herpes-simplex-virus-type-1
HSV1 in small children who suck on their fingers causes the infection of fingers "herpetic whitlow"
Nodding disease only affects children under the age of 15. Is this because adults don't typically develop HSV1 outside of the mouth?
could it be molluscum contagiosum?
nodding syndrome/ grand-mal seizures and OV
https://idpjournal.biomedcentral.com/articles/10.1186/s40249-018-0450-3
hippocampus and body temp
http://www.jneurosci.org/content/27/7/1566
hippocampus and food
https://www.ncbi.nlm.nih.gov/pubmed/28616995
https://www.ncbi.nlm.nih.gov/pubmed/28616995
The children nod when exposed to temperature changes or food.
Are Focal seizures different? Are they caused by protozoas?
epilepsy and anti-gangliosides
https://www.ncbi.nlm.nih.gov/pubmed/7472306
Focal seizures and Schizophrenia
https://www.health.harvard.edu/newsletter_article/schizophrenia-and-epilepsy
( Toxoplasma gondii)
https://www.ncbi.nlm.nih.gov/pubmed/7472306
Focal seizures and Schizophrenia
https://www.health.harvard.edu/newsletter_article/schizophrenia-and-epilepsy
( Toxoplasma gondii)
Febrile seizures and enteroviruses???
https://www.ncbi.nlm.nih.gov/pubmed/11134476
febrile seizure that lasts more than ten minutes is complex
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