Hypotheses:
27HC binds cytosolic viruses and holds them outside of the cell membrane while inflammasomes create GSDM windows in the membrane for the antibodies to bind large cytosol infections.
Or HC could mark the exosomes based on what it's carrying. Cancer vs cytosol virus or mito/nuclear virus so the cd169 cells who pick up the exosomes know what they have.
IgG2 and phagocytosis by neutrophils and monocytes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1457935/
https://iai.asm.org/content/iai/63/3/1070.full.pdf
influenza and phagocytosis
http://www.jimmunol.org/content/178/4/2448
25HC and inflammatory reaction to influenza
https://www.ncbi.nlm.nih.gov/pubmed/24994901
Exosomes and HC
Exosomes and dendritic cells
https://www.nature.com/articles/s41598-017-16609-6
cd169 (of scs macrophages in the lymph) mediates capture of exosomes
http://www.bloodjournal.org/content/123/2/208?sso-checked=true
exosomes and lymph nodes
https://www.sciencedirect.com/science/article/pii/S1084952116304414
25-HC enveloped viruses and 27-HC non-enveloped viruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265783/
Or are these nuclear/mito viruses? Herpes, flu, HIV, and HBV are all nuclear/mito viruses that would be taken up by pDendritic
27-HC Breast cancer exosomes
https://www.researchgate.net/publication/293885899_Mass_spectrometric_detection_of_27-hydroxycholesterol_in_breast_cancer_exosomes
Cancers are started by nuclear viruses but they are are growing out of control without viral participation rather they are open book growth. (the carcionogen inhibited the virus)
scs with cd169 presents viral proteins to B cells
https://www.ncbi.nlm.nih.gov/pubmed/17934446
Does the 27HC hold the viral RNA outside of infected cells for dendritic cells?
Flu B and C infects the cytosol of cells and the 25HC secreted by macrophages would insert themselves in the membranes of cells in the region...and hold the foreign viral RNA outside of the cells?
But for type A which infects the mitochondria it would lower il-10?
How does the RNA viruses in the cytosol get seen by antibodies of the immune system if the MHC1 is for mitochondrial and nuclear infections?
the inflammasome and Actinobacillus actinomycetemcomitans
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490745/
IgG2 and Actinobacillus actinomycetemcomitans
https://iai.asm.org/content/iai/63/3/1070.full.pdf
when the inflammasomes are involved the cells get IgG2 phagocytosis by eosinophils?
The infected cells were surrounded by eosinophils
https://pdfs.semanticscholar.org/a96e/7dd46755be7d0fe30724dfe926e1859e6133.pdf
neutrophils and IgG2 killing of actinobacillus
https://iai.asm.org/content/63/3/1070
when the actinobacillus is not in the cytosol but outside of cells?
Older hypothesis post
https://angelabiggs.blogspot.com/2018/04/igg2-hypotheses-requests-role-of-25hc.html
newer hypotheses
https://angelabiggs.blogspot.com/2019/02/hypothesis-gsdm-pyroptosis-is-parasite.html
27HC binds cytosolic viruses and holds them outside of the cell membrane while inflammasomes create GSDM windows in the membrane for the antibodies to bind large cytosol infections.
Or HC could mark the exosomes based on what it's carrying. Cancer vs cytosol virus or mito/nuclear virus so the cd169 cells who pick up the exosomes know what they have.
IgG2 and phagocytosis by neutrophils and monocytes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1457935/
https://iai.asm.org/content/iai/63/3/1070.full.pdf
influenza and phagocytosis
http://www.jimmunol.org/content/178/4/2448
25HC and inflammatory reaction to influenza
https://www.ncbi.nlm.nih.gov/pubmed/24994901
Exosomes and HC
Exosomes and dendritic cells
https://www.nature.com/articles/s41598-017-16609-6
cd169 (of scs macrophages in the lymph) mediates capture of exosomes
http://www.bloodjournal.org/content/123/2/208?sso-checked=true
exosomes and lymph nodes
https://www.sciencedirect.com/science/article/pii/S1084952116304414
25-HC enveloped viruses and 27-HC non-enveloped viruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265783/
Or are these nuclear/mito viruses? Herpes, flu, HIV, and HBV are all nuclear/mito viruses that would be taken up by pDendritic
27-HC Breast cancer exosomes
https://www.researchgate.net/publication/293885899_Mass_spectrometric_detection_of_27-hydroxycholesterol_in_breast_cancer_exosomes
Cancers are started by nuclear viruses but they are are growing out of control without viral participation rather they are open book growth. (the carcionogen inhibited the virus)
scs with cd169 presents viral proteins to B cells
https://www.ncbi.nlm.nih.gov/pubmed/17934446
Does the 27HC hold the viral RNA outside of infected cells for dendritic cells?
Flu B and C infects the cytosol of cells and the 25HC secreted by macrophages would insert themselves in the membranes of cells in the region...and hold the foreign viral RNA outside of the cells?
But for type A which infects the mitochondria it would lower il-10?
How does the RNA viruses in the cytosol get seen by antibodies of the immune system if the MHC1 is for mitochondrial and nuclear infections?
the inflammasome and Actinobacillus actinomycetemcomitans
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490745/
IgG2 and Actinobacillus actinomycetemcomitans
https://iai.asm.org/content/iai/63/3/1070.full.pdf
when the inflammasomes are involved the cells get IgG2 phagocytosis by eosinophils?
The infected cells were surrounded by eosinophils
https://pdfs.semanticscholar.org/a96e/7dd46755be7d0fe30724dfe926e1859e6133.pdf
neutrophils and IgG2 killing of actinobacillus
https://iai.asm.org/content/63/3/1070
when the actinobacillus is not in the cytosol but outside of cells?
Older hypothesis post
https://angelabiggs.blogspot.com/2018/04/igg2-hypotheses-requests-role-of-25hc.html
newer hypotheses
https://angelabiggs.blogspot.com/2019/02/hypothesis-gsdm-pyroptosis-is-parasite.html
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