Hypothesis: TH17 are cells secrete il-20 cytokines which pop the organelles because they appear with infections that are further inside like vacuoles or the mitochondria. A second popping is needed for the immune system to see the infection. The question is how?
il-17a does call neutrophils which helps fight fungal infections
virus activates il-1beta
https://www.ncbi.nlm.nih.gov/pubmed/10358182
il-1beta and il-23 activate the differentiation of TH17
https://www.cell.com/cell-reports/pdf/S2211-1247(18)30225-0.pdf
il-23 is triggered by intracellular bacteria
http://www.jimmunol.org/content/183/12/8026
Hypothesis
The cytokines of TH17 cells pop the organelles of the cell.
Reposted from before:
The il-20 Family is secreted by Th17
il-20 Family includes: il-26, il-19, il-22, and il-24
il-26 nucleus
il-19 disruption of mitochondria
il-22 chlamydia/ gonorrhoeae/ h.pylori in vacuoles
il-24 salmonella in the golgi
Nucleus: il-26
il-26 PORE with DNA (used for a second popping of membranes like the mitochondria and nucleus or internalized infections)
https://www.nature.com/articles/ni.3211
( TLR-9 I had linked to being the net of the mitochondria )
http://angelabiggs.blogspot.com/2017/01/tlrs-toll-like-receptors-summary.html
il-26 and herpes viruses
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070281
Mitochondria il-19
il-19 and acute kidney failure due to mitochondrial induced apoptosis
https://books.google.com/books?id=n9ocHWITPnoC&pg=PA51&lpg=PA51&dq=il-19+mitochondria&source=bl&ots=1sfmQISyik&sig=bgu8tG8Vy7EB0Q5SueB8jaFX8fE&hl=en&sa=X&ved=2ahUKEwi1nJrxk6PfAhVF4IMKHddSD_0Q6AEwBnoECAgQAQ#v=onepage&q=il-19%20mitochondria&f=false
th17 and herpes zoster
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597651/
Golgi: il-24
salmonella nests inside of cells in vacole near golgi
https://www.ncbi.nlm.nih.gov/pubmed/18778407
il-24 protects against salmonella infection
https://www.ncbi.nlm.nih.gov/pubmed/1983073
Golgi and il-24 with melanoma (supporting connection)
https://www.ncbi.nlm.nih.gov/pubmed/15126330
golgi and ER relationship....IFNgamma
https://www.ncbi.nlm.nih.gov/pubmed/10712678
ifn gamma and tnf with salmonella
https://www.karger.com/Article/Pdf/163643
Vacuoles: il-22
Chlamydia moves inside of cells to replicate
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886739/
chlamydia and il-22
http://europepmc.org/abstract/MED/24531835
il-23 triggers Th17 to release il-22 and il-17
https://www.ncbi.nlm.nih.gov/pubmed/24238108
H.pylori and il-23
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342083/
H.pylori and il-22
https://www.ncbi.nlm.nih.gov/pubmed/26867135
H.pylori replicates in vacuoles
http://iai.asm.org/content/78/10/4157.full
il-17a does call neutrophils which helps fight fungal infections
virus activates il-1beta
https://www.ncbi.nlm.nih.gov/pubmed/10358182
il-1beta and il-23 activate the differentiation of TH17
https://www.cell.com/cell-reports/pdf/S2211-1247(18)30225-0.pdf
il-23 is triggered by intracellular bacteria
http://www.jimmunol.org/content/183/12/8026
Hypothesis
The cytokines of TH17 cells pop the organelles of the cell.
Reposted from before:
The il-20 Family is secreted by Th17
il-20 Family includes: il-26, il-19, il-22, and il-24
il-26 nucleus
il-19 disruption of mitochondria
il-22 chlamydia/ gonorrhoeae/ h.pylori in vacuoles
il-24 salmonella in the golgi
Nucleus: il-26
il-26 PORE with DNA (used for a second popping of membranes like the mitochondria and nucleus or internalized infections)
https://www.nature.com/articles/ni.3211
( TLR-9 I had linked to being the net of the mitochondria )
http://angelabiggs.blogspot.com/2017/01/tlrs-toll-like-receptors-summary.html
il-26 and herpes viruses
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070281
Mitochondria il-19
il-19 and acute kidney failure due to mitochondrial induced apoptosis
https://books.google.com/books?id=n9ocHWITPnoC&pg=PA51&lpg=PA51&dq=il-19+mitochondria&source=bl&ots=1sfmQISyik&sig=bgu8tG8Vy7EB0Q5SueB8jaFX8fE&hl=en&sa=X&ved=2ahUKEwi1nJrxk6PfAhVF4IMKHddSD_0Q6AEwBnoECAgQAQ#v=onepage&q=il-19%20mitochondria&f=false
th17 and herpes zoster
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597651/
Golgi: il-24
salmonella nests inside of cells in vacole near golgi
https://www.ncbi.nlm.nih.gov/pubmed/18778407
il-24 protects against salmonella infection
https://www.ncbi.nlm.nih.gov/pubmed/1983073
Golgi and il-24 with melanoma (supporting connection)
https://www.ncbi.nlm.nih.gov/pubmed/15126330
golgi and ER relationship....IFNgamma
https://www.ncbi.nlm.nih.gov/pubmed/10712678
https://www.karger.com/Article/Pdf/163643
Vacuoles: il-22
Chlamydia moves inside of cells to replicate
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886739/
chlamydia and il-22
http://europepmc.org/abstract/MED/24531835
il-23 triggers Th17 to release il-22 and il-17
https://www.ncbi.nlm.nih.gov/pubmed/24238108
H.pylori and il-23
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342083/
H.pylori and il-22
https://www.ncbi.nlm.nih.gov/pubmed/26867135
H.pylori replicates in vacuoles
http://iai.asm.org/content/78/10/4157.full
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