Neutrophils secrete fasL
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278510/
Monocytes, eosinophils, and neutrophils express fas and this is a way to stop quickly inflammation
il-13 suppresses apoptosis
http://www.jimmunol.org/content/jimmunol/161/6/2863.full.pdf
Monocytes, eosinophils, and neutrophils all have il-13 receptors which means they do not go through apoptosis if il-13 is around.
During cytosolic infections by bacteria or parasites the myeloid Dendritic cells instead of intereacting with TH1 hands the MHC2 with a protein in it off to a basophil who then as the liaison shows the TH2 cells instead. TH2 cells then make il-13 not just il-4.
This means that when a cytosolic infection occurs and the CTL-fas ligand pathway is triggered the phagocytes are not going to apoptosis only the parasite infected cells. At least until the il-13 wears off.
Like viruses of the cytosol there is more than one way to kill bacterial infections of the cytosol.
cytosolic receptor for bacteria
https://www.nature.com/articles/s41586-018-0433-3
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278510/
Monocytes, eosinophils, and neutrophils express fas and this is a way to stop quickly inflammation
il-13 suppresses apoptosis
http://www.jimmunol.org/content/jimmunol/161/6/2863.full.pdf
Monocytes, eosinophils, and neutrophils all have il-13 receptors which means they do not go through apoptosis if il-13 is around.
During cytosolic infections by bacteria or parasites the myeloid Dendritic cells instead of intereacting with TH1 hands the MHC2 with a protein in it off to a basophil who then as the liaison shows the TH2 cells instead. TH2 cells then make il-13 not just il-4.
This means that when a cytosolic infection occurs and the CTL-fas ligand pathway is triggered the phagocytes are not going to apoptosis only the parasite infected cells. At least until the il-13 wears off.
Like viruses of the cytosol there is more than one way to kill bacterial infections of the cytosol.
cytosolic receptor for bacteria
https://www.nature.com/articles/s41586-018-0433-3
This comment has been removed by a blog administrator.
ReplyDelete