Aquaporins allow motility in immune system cells. When antibodies against these water-pores appears in autoimmune disease is it when the immune system is stopping a pathway?

Autoimmune cross-targeting hypothesis: when two infections are on one target typically the immune attack on the larger infection is stopped. This "stopping" action can trigger autoimmune disease.

For transverse myelitis two infections are suspected: the flu virus and fungal infections of the spinal cord like aspergillus ? Or is it mycobacteria?

For Neuromyelitis optica two infections suspected: mycobacteria and the a virus....flu, herpes, dengue...

Fungal infections primarily involve the recruitment of neutrophils.

Transverse myelitis and aquaporin :  some have aquaporin-4 but not all. Are there 2 types?
https://jamanetwork.com/journals/jamaneurology/fullarticle/1733321

Neuromyelitis optica and anti-aquaporin-4
https://www.ncbi.nlm.nih.gov/pubmed/18808744
https://hub.hku.hk/bitstream/10722/250540/1/content.pdf

Antibodies to aquaporin 8 and 9 in SS Sjögren's syndrome 
https://academic.oup.com/rheumatology/article-abstract/56/12/2114/4100683

transverse myelitis and ss Sjögren's syndrome (fungal)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502814/

neuromyelitis and tuberculous (mycobacteria)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938476/

Eosinophils combat mycobacterias. Is this why Neuromyelitis has anti-aquaporin 4?
Aquaporins are used for motility by the immune system cells. (ha ha makes you think of them as little motor boats)

Eosinophils and aquaporin-4
https://www.sciencedirect.com/science/article/pii/S096758681731069X

macrophages M1 use aquaporin-1 for motility
https://www.ncbi.nlm.nih.gov/pubmed/25719758

macrophage M2 and aquaporin-3
https://www.nature.com/articles/srep25781

dendritic cells express aquaporin-3 and aquaporin-5
https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajh.10476

Aquaporin-9 has high expression in  Neutrophils for motility
https://www.nature.com/articles/srep15319

Neutrophils combat fungal infections.  Is this why Sjogren's syndrome has anti-aquaporin 9 appears?

Aquaporin 8 localized to mitochondria
https://www.sciencedirect.com/science/article/pii/S2405580815000898

Is the immune system trying to stop the larger infection by targeting the aquaporins used for motility by the immune system? Are these IgG4 or IgG1? I would think it would be IgG4 if it was the immune system was shutting itself down.

The problem arises because aquaporin-4 is the main water channel in nerves
https://www.ncbi.nlm.nih.gov/pubmed/15561407

Aquaporin- 9 has high expression in glial cells (non neural cells of the brain and spinal cord)
https://www.ncbi.nlm.nih.gov/pubmed/15450351
https://www.ncbi.nlm.nih.gov/pubmed/15561412

Is the phantom pain from the glial cells in Sjogren's?

Does not seem to match up yet:

IgG4 related disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902347/

Classified autoimmune IgG4
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816565/

previous post:

flu vaccine and transverse myelitis
https://www.ncbi.nlm.nih.gov/pubmed/20697056
https://www.ncbi.nlm.nih.gov/pubmed/21598817

lupus and transverse myelitis
https://www.ncbi.nlm.nih.gov/pubmed/2179553
https://www.ncbi.nlm.nih.gov/pubmed/3632736
https://www.ncbi.nlm.nih.gov/pubmed/1643455
https://www.ncbi.nlm.nih.gov/pubmed/9707792

transverse myelitis, MS,  neuromyelitis optica (mycobacteria?)
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0100672

flu virus and neuromyelitis optica
https://www.ncbi.nlm.nih.gov/pubmed/21804290

dengue virus and neuromelitis optica
https://www.ncbi.nlm.nih.gov/pubmed/29475624

herpes zoster and neuromelitis optica
http://n.neurology.org/content/86/16_Supplement/P6.159

Idiopathic transverse myelitis and HLA-DR2
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151596/

HLA-DR2 and the flu

oral polio vaccine and neuromyelitis? or is this AFM?
https://www.ncbi.nlm.nih.gov/pubmed/16630313
https://www.ncbi.nlm.nih.gov/pubmed/19269246
https://www.ncbi.nlm.nih.gov/pubmed/9842449

would this be more of an AFM because it's an enterovirus?

oral polio vaccine paralysis issues factsheet
http://www.who.int/immunization/diseases/poliomyelitis/endgame_objective2/oral_polio_vaccine/VAPPandcVDPVFactSheet-Feb2015.pdf

Fungal infection and transverse myelitis
http://insights.sagepub.com/fungal-partial-transverse-myelitis-of-the-cervical-spine-in-an-immunoc-article-a4645
http://www.exoticpetmedicine.com/article/S1557-5063(15)00013-0/abstract

schistosomiasis and transverse myelitis
https://www.cdc.gov/mmwr/preview/mmwrhtml/00000385.htm
(schistosomiasis are parasitic snail worms)