Thursday, April 12, 2018

New HLA thoughts

HLA-DM on dendritic bone marrow cells
https://www.ncbi.nlm.nih.gov/pubmed/10971396

HLA-DM matches up with IgA1 which is primarily made at the bone marrow plasma cells

il-5 is the bone marrow cytokine (highest amount there)

il-5 was once called the eosinophil factor because they have the most il-5 receptors (basophils also have il-5 receptors)

il-5 can also be secreted by eosinophils

Does il-5 favor the HLA-DM and the IgA1 ?

Previously linking the HLAs to the viruses' locations resulted in:

HLA-A nuclear
HLA-B mitochondria
HLA-C ER
HLA-Dq/ Dr cytosol or outside where HLA-dr is RNA binding

These HLAs were viewed by T cells....but HLA-C was viewed by NK cells

HLA-C and Natural killer cells
https://www.ncbi.nlm.nih.gov/pubmed/27521484

The HLA looked at by NK natural killer cells have specific locations they represent.

HLA-E salmonella (nests in the golgi)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028793/

HLA-G Pseudomonas aeruginosa (exosomes)
https://www.ncbi.nlm.nih.gov/pubmed/26934639
http://microvesicles.org/gene_summary?gene_id=878180

HLA-F Japanese encepalitis virus (Lysomsomes ?)
https://www.sciencedirect.com/science/article/pii/S0042682214004462
https://www.researchgate.net/publication/13224636_Effect_of_bafilomycin_A1_on_the_growth_of_Japanese_encephalitis_virus_in_Vero_cells




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