Thursday, April 5, 2018

il-17, Neutrophils, and fungal infections

Th17 cells are involved with the second popping of infections hiding inside host cells.

The il-17 cytokines associated with Th17 are also involved with killing extremely large infections where il-17 up regulates neutrophils and CTLs

il-17a il-17f and neutrophils
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759196/

neutrophils kill fungal infections

C-type lectin receptors on macrophages, dendritic cells, and neutrophils sense fungal infections. Dectin-1 detects B13glucan on candida, aspergillus, and saccharmyces. Dectin-2 binds high mannose structures on cryptococcus and trichophyton. 

Dectin-1 

neutrophils produce il-17a in a dectin-1 

il-17a induces CTL cells which have been shown to kill not just host cells infected with viruses but fungal infections


fungal infections trigger the release of TGF-b1
https://www.ncbi.nlm.nih.gov/pubmed/11447193

My current cytokine hypothesis for TH17 cells

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