This blog focuses primarily on cross-targeting autoimmunity. In the case of schizophrenia it has become apparent that at least 2 types exist that involve infections cross-targeting with viral infections.
Fungal infections could cause manifest with other autoimmune diseases like Sjogern's, Asperger's, and Hashimotos thyroid. These fungal infections are dimorphic thus causing the person to have sensitivities to corn, soy, and estrogen. Dimorphic means that they shift as a fungal infection between a yeast and a mold state of morphology. An example of a fungal infection is Candida. The fungal infection might break the blood brain barrier allowing a virus like cmv into the brain. The key is that these ,unlike T.gondii, would be estrogen sensitive.
Schizophrenia has also been associated with T.gondii infections which trigger strong gluten and casein sensitivities. There appears to be gluten and casein sensitivities when small infections cross barriers like the intestine or the blood brain barrier....or at least that is my prediction.
I had contrasted Asperger's and schizophrenia looking at both of these infections before.
http://angelabiggs.blogspot.com/2014/04/aspergers-and-schizophernia-both.html
asperger's with schizophrenia
http://www.ncbi.nlm.nih.gov/pubmed/23065028
http://link.springer.com/article/10.1007%2Fs00787-012-0338-x#page-1
This page is under construction as I organize references and explain my thoughts for linking them.
The Cross-targeting hypothesis: when a viral infection overlaps a basic infection on/in one cell type, in this case neurons, thus confusing the immune system and generating an autoimmune attack against self.
First Schizophrenia has 2 core autoimmune antibodies:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065649/
Voltage gated potassium channels and then the NMDA receptor. The larger infections tend to generate these antibodies while the viruses tend to infect the neurons themselves....except the flu which does generate even in vaccine form antibodies against neurons.
The anti-voltage gated potassium channel is responsible for hallucinations
anti-voltage-gated potassium channel antibodies associated encephalopathy is autoimmune
http://www.ncbi.nlm.nih.gov/pubmed/14960497
anti-voltage-gated potassium channel antibodies and auditory hallucinations
http://www.ncbi.nlm.nih.gov/pubmed/24571022
vgkc antibodies and seizures in cats
http://www.ncbi.nlm.nih.gov/pubmed/23278981
vgkc and children
http://www.ncbi.nlm.nih.gov/pubmed/21464429
potassium flow in schizophrenia and gene for the potassium channel
http://www.nih.gov/news/health/may2009/nimh-05.htm
The NMDA receptor seems to cause the mania, seizures, paranoia, and catatonic symptoms after flu like fevers
http://www.ncbi.nlm.nih.gov/pubmed/24731834
http://www.ncbi.nlm.nih.gov/pubmed/18807939
NMDA and narcolepsy
http://www.ncbi.nlm.nih.gov/pubmed/22569157
http://www.ncbi.nlm.nih.gov/pubmed/18446324
http://www.ncbi.nlm.nih.gov/pubmed/12611960
NMDA and fear
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263393/
The fungal kind of schizophrenia:
Hashimotos and encephalopathy
http://www.ncbi.nlm.nih.gov/pubmed/25116126
http://www.ncbi.nlm.nih.gov/pubmed/22474467 (with hallucinations)
autoantibodies against the NH2-terminal of a-enolase (NAE) as a specific diagnostic marker for HE
http://www.ncbi.nlm.nih.gov/pubmed/19363998
http://www.ncbi.nlm.nih.gov/pubmed/17335908
Hashimotos and voltage gated potassium channels are different from encephalopathy?
http://www.ncbi.nlm.nih.gov/pubmed/1507901
SJ and Schizophrenia
http://www.researchgate.net/publication/232431729_Relation_between_schizophrenic-like_psychosis_and_Sjogren's_syndrome_(SS)
http://www.ncbi.nlm.nih.gov/pubmed/3679782
http://www.ncbi.nlm.nih.gov/pubmed/22442099
http://www.ncbi.nlm.nih.gov/pubmed/16513876
http://www.hcplive.com/articles/Autoimmune-Disease-Schizophrenia-and-Bipolar-Disorder
NMDA and Sjogren's
http://www.ncbi.nlm.nih.gov/pubmed/15708887
http://www.ncbi.nlm.nih.gov/pubmed/16868971
Potassium deficiency and Candida...does this cause the malfunction of the channel?
http://www.livestrong.com/article/335327-potassium-deficiency-candida/
The T.gondii kind of schizophrenia:
t.gondii and encephal
http://en.wikipedia.org/wiki/Toxoplasmosis
http://www.ncbi.nlm.nih.gov/pubmed/14725265
Gluten and casein with schizophrenia
http://www.ncbi.nlm.nih.gov/pubmed/25241021
anti-gluten after t.gondii infects mice
http://www.ncbi.nlm.nih.gov/pubmed/23209841
schizophrenia and gluten sensitivity
http://www.ncbi.nlm.nih.gov/pubmed/22446142
malaria parasite and the potassium channel
http://www.science20.com/news_releases/disrupting_potassium_channel_in_malaria_parasite_blocks_transmission
T.gondii infects like the malaria parasite and involves the potassium channel? ???
http://www.science20.com/news_articles/toxoplasma_gondii_study_turns_parasite_invasion_theory_its_head-99796
My Older post of pan-apple domains, t.gondii, and the NMDA receptor
In our body when blood clots are degraded, plasminogen which has the PAN sequence in it, is activated by tPA (tissue plasminogen activator)
t-PA binds not just plasminogen but the NMDA receptor. Does this mean the NMDA receptor has a PAN/apple domain?
ref: t-PA is a new ligand of NMDA receptor
JBC papers Sept 23. 2004
t.gondii and pan-apple
http://connection.ebscohost.com/c/articles/77507454/novel-pan-apple-domain-containing-protein-from-toxoplasma-gondii-characterization-receptor-identification
If antibodies develop against T.gondii included the pan/apple domain does this mean the antibodies might also bind the NMDA receptor? and the over stimulation of the receptor would mean down regulation and hence the loss of fear initially seen?
CMV virus inhibits the expression of NMDA
http://www.ncbi.nlm.nih.gov/pubmed/15759129
viral infections or drugs are under consideration for the cross-targeting
the flu virus during pregnancy and schizophrenia
http://www.schizophrenia.com/prevention/maternal.html
the flu vaccine and narcolepsy which might overlap schizo
http://www.ncbi.nlm.nih.gov/pubmed/24849861
http://www.newscientist.com/article/dn24772-flu-vaccine-helps-unravel-complex-causes-of-narcolepsy.html#.VFo6_fnF-So
herpes virus 6 and 8 (these infect the neurons themselves and because they damage the mitochondria this might overlap with alzheimer's)
http://www.ncbi.nlm.nih.gov/pubmed/24139899
http://www.ncbi.nlm.nih.gov/pubmed/14991372
http://www.ncbi.nlm.nih.gov/pubmed/?term=herpesvirus+8+schizophrenia+2013
http://www.uptodate.com/contents/human-herpesvirus-6-infection-in-hematopoietic-cell-transplant-recipients
http://www.ncbi.nlm.nih.gov/pubmed/17981263
herpes 6 can reactivate cmv
http://jid.oxfordjournals.org/content/181/4/1450.long
CMV (Cytomegalovirus, also known as HCMV, CMV or Human Herpes virus 5 (HHV-5) )
http://www.ncbi.nlm.nih.gov/pubmed/24083998
http://www.ncbi.nlm.nih.gov/pubmed/25351544
Herv W
http://www.ncbi.nlm.nih.gov/pubmed/20100784
special note that T.gondii is currently under investigation for awakening herv
http://www.ncbi.nlm.nih.gov/pubmed/17054075
in other words T.gondii may create it's own cross-targeting reaction as part of the mind control
HIV?
http://www.ncbi.nlm.nih.gov/pubmed/11394192
Paranoid schizophrenia could be caused by dopamine high activity in the hippocampus
http://www.ncbi.nlm.nih.gov/pubmed/1349833
Meth causes dopamine disfunction of the hippocampus
http://www.ncbi.nlm.nih.gov/pubmed/20074221
cannabis and schizophrenia
http://www.ncbi.nlm.nih.gov/pubmed/16319402
http://www.ncbi.nlm.nih.gov/pubmed/10881971
extra note about t.gondii
http://www.ncbi.nlm.nih.gov/pubmed/11429165
Fungal infections could cause manifest with other autoimmune diseases like Sjogern's, Asperger's, and Hashimotos thyroid. These fungal infections are dimorphic thus causing the person to have sensitivities to corn, soy, and estrogen. Dimorphic means that they shift as a fungal infection between a yeast and a mold state of morphology. An example of a fungal infection is Candida. The fungal infection might break the blood brain barrier allowing a virus like cmv into the brain. The key is that these ,unlike T.gondii, would be estrogen sensitive.
Schizophrenia has also been associated with T.gondii infections which trigger strong gluten and casein sensitivities. There appears to be gluten and casein sensitivities when small infections cross barriers like the intestine or the blood brain barrier....or at least that is my prediction.
I had contrasted Asperger's and schizophrenia looking at both of these infections before.
http://angelabiggs.blogspot.com/2014/04/aspergers-and-schizophernia-both.html
asperger's with schizophrenia
http://www.ncbi.nlm.nih.gov/pubmed/23065028
http://link.springer.com/article/10.1007%2Fs00787-012-0338-x#page-1
This page is under construction as I organize references and explain my thoughts for linking them.
The Cross-targeting hypothesis: when a viral infection overlaps a basic infection on/in one cell type, in this case neurons, thus confusing the immune system and generating an autoimmune attack against self.
First Schizophrenia has 2 core autoimmune antibodies:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065649/
Voltage gated potassium channels and then the NMDA receptor. The larger infections tend to generate these antibodies while the viruses tend to infect the neurons themselves....except the flu which does generate even in vaccine form antibodies against neurons.
The anti-voltage gated potassium channel is responsible for hallucinations
anti-voltage-gated potassium channel antibodies associated encephalopathy is autoimmune
http://www.ncbi.nlm.nih.gov/pubmed/14960497
anti-voltage-gated potassium channel antibodies and auditory hallucinations
http://www.ncbi.nlm.nih.gov/pubmed/24571022
vgkc antibodies and seizures in cats
http://www.ncbi.nlm.nih.gov/pubmed/23278981
vgkc and children
http://www.ncbi.nlm.nih.gov/pubmed/21464429
potassium flow in schizophrenia and gene for the potassium channel
http://www.nih.gov/news/health/may2009/nimh-05.htm
The NMDA receptor seems to cause the mania, seizures, paranoia, and catatonic symptoms after flu like fevers
http://www.ncbi.nlm.nih.gov/pubmed/24731834
http://www.ncbi.nlm.nih.gov/pubmed/18807939
NMDA and narcolepsy
http://www.ncbi.nlm.nih.gov/pubmed/22569157
http://www.ncbi.nlm.nih.gov/pubmed/18446324
http://www.ncbi.nlm.nih.gov/pubmed/12611960
NMDA and fear
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263393/
The fungal kind of schizophrenia:
Hashimotos and encephalopathy
http://www.ncbi.nlm.nih.gov/pubmed/25116126
http://www.ncbi.nlm.nih.gov/pubmed/22474467 (with hallucinations)
autoantibodies against the NH2-terminal of a-enolase (NAE) as a specific diagnostic marker for HE
http://www.ncbi.nlm.nih.gov/pubmed/19363998
http://www.ncbi.nlm.nih.gov/pubmed/17335908
Hashimotos and voltage gated potassium channels are different from encephalopathy?
http://www.ncbi.nlm.nih.gov/pubmed/1507901
SJ and Schizophrenia
http://www.researchgate.net/publication/232431729_Relation_between_schizophrenic-like_psychosis_and_Sjogren's_syndrome_(SS)
http://www.ncbi.nlm.nih.gov/pubmed/3679782
http://www.ncbi.nlm.nih.gov/pubmed/22442099
http://www.ncbi.nlm.nih.gov/pubmed/16513876
http://www.hcplive.com/articles/Autoimmune-Disease-Schizophrenia-and-Bipolar-Disorder
NMDA and Sjogren's
http://www.ncbi.nlm.nih.gov/pubmed/15708887
http://www.ncbi.nlm.nih.gov/pubmed/16868971
Potassium deficiency and Candida...does this cause the malfunction of the channel?
http://www.livestrong.com/article/335327-potassium-deficiency-candida/
The T.gondii kind of schizophrenia:
t.gondii and encephal
http://en.wikipedia.org/wiki/Toxoplasmosis
http://www.ncbi.nlm.nih.gov/pubmed/14725265
Gluten and casein with schizophrenia
http://www.ncbi.nlm.nih.gov/pubmed/25241021
anti-gluten after t.gondii infects mice
http://www.ncbi.nlm.nih.gov/pubmed/23209841
schizophrenia and gluten sensitivity
http://www.ncbi.nlm.nih.gov/pubmed/22446142
malaria parasite and the potassium channel
http://www.science20.com/news_releases/disrupting_potassium_channel_in_malaria_parasite_blocks_transmission
T.gondii infects like the malaria parasite and involves the potassium channel? ???
http://www.science20.com/news_articles/toxoplasma_gondii_study_turns_parasite_invasion_theory_its_head-99796
My Older post of pan-apple domains, t.gondii, and the NMDA receptor
In our body when blood clots are degraded, plasminogen which has the PAN sequence in it, is activated by tPA (tissue plasminogen activator)
t-PA binds not just plasminogen but the NMDA receptor. Does this mean the NMDA receptor has a PAN/apple domain?
ref: t-PA is a new ligand of NMDA receptor
JBC papers Sept 23. 2004
t.gondii and pan-apple
http://connection.ebscohost.com/c/articles/77507454/novel-pan-apple-domain-containing-protein-from-toxoplasma-gondii-characterization-receptor-identification
If antibodies develop against T.gondii included the pan/apple domain does this mean the antibodies might also bind the NMDA receptor? and the over stimulation of the receptor would mean down regulation and hence the loss of fear initially seen?
CMV virus inhibits the expression of NMDA
http://www.ncbi.nlm.nih.gov/pubmed/15759129
viral infections or drugs are under consideration for the cross-targeting
the flu virus during pregnancy and schizophrenia
http://www.schizophrenia.com/prevention/maternal.html
the flu vaccine and narcolepsy which might overlap schizo
http://www.ncbi.nlm.nih.gov/pubmed/24849861
http://www.newscientist.com/article/dn24772-flu-vaccine-helps-unravel-complex-causes-of-narcolepsy.html#.VFo6_fnF-So
herpes virus 6 and 8 (these infect the neurons themselves and because they damage the mitochondria this might overlap with alzheimer's)
http://www.ncbi.nlm.nih.gov/pubmed/24139899
http://www.ncbi.nlm.nih.gov/pubmed/14991372
http://www.ncbi.nlm.nih.gov/pubmed/?term=herpesvirus+8+schizophrenia+2013
http://www.uptodate.com/contents/human-herpesvirus-6-infection-in-hematopoietic-cell-transplant-recipients
http://www.ncbi.nlm.nih.gov/pubmed/17981263
herpes 6 can reactivate cmv
http://jid.oxfordjournals.org/content/181/4/1450.long
CMV (Cytomegalovirus, also known as HCMV, CMV or Human Herpes virus 5 (HHV-5) )
http://www.ncbi.nlm.nih.gov/pubmed/24083998
http://www.ncbi.nlm.nih.gov/pubmed/25351544
Herv W
http://www.ncbi.nlm.nih.gov/pubmed/20100784
special note that T.gondii is currently under investigation for awakening herv
http://www.ncbi.nlm.nih.gov/pubmed/17054075
in other words T.gondii may create it's own cross-targeting reaction as part of the mind control
HIV?
http://www.ncbi.nlm.nih.gov/pubmed/11394192
Paranoid schizophrenia could be caused by dopamine high activity in the hippocampus
http://www.ncbi.nlm.nih.gov/pubmed/1349833
Meth causes dopamine disfunction of the hippocampus
http://www.ncbi.nlm.nih.gov/pubmed/20074221
cannabis and schizophrenia
http://www.ncbi.nlm.nih.gov/pubmed/16319402
http://www.ncbi.nlm.nih.gov/pubmed/10881971
extra note about t.gondii
http://www.ncbi.nlm.nih.gov/pubmed/11429165
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