This is a hypothesis blog and not proven...yet.
Molecular mimicry is when an infection's protein looks like a host's protein. (they are not the same but close enough the antibody flags mark them)
Cross-reactivity is when 2 different infections have the same protein causing the immune system to overlap. (A cross-target of a protein) If the host has the same protein or molecular mimicry is occurring autoimmunity would develop.
example : Hemagglutinin is on mycoplasma gallispeticum and on flu viruses. Infections use hemagglutinin to bind host receptors which then allow them to enter host cells.
Cross-targeting is when 2 different types of infections cause the immune system to target the same organ or cell type. An example would be the pancreas in type one diabetes: mycoplasmas could infect the pancreas then a flu virus replicates in it.
(viruses replicate and infect only some cell types and this will correspond to the autoimmune diseases they trigger)
It is my hypothesis that autoimmunity occurs when for some reason the immune system overlaps on self.
Molecular mimicry is when an infection's protein looks like a host's protein. (they are not the same but close enough the antibody flags mark them)
Cross-reactivity is when 2 different infections have the same protein causing the immune system to overlap. (A cross-target of a protein) If the host has the same protein or molecular mimicry is occurring autoimmunity would develop.
example : Hemagglutinin is on mycoplasma gallispeticum and on flu viruses. Infections use hemagglutinin to bind host receptors which then allow them to enter host cells.
Cross-targeting is when 2 different types of infections cause the immune system to target the same organ or cell type. An example would be the pancreas in type one diabetes: mycoplasmas could infect the pancreas then a flu virus replicates in it.
(viruses replicate and infect only some cell types and this will correspond to the autoimmune diseases they trigger)
It is my hypothesis that autoimmunity occurs when for some reason the immune system overlaps on self.
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