Two types of CTL: CTL-Fas with cytosol viral infections and CTL-TCR with nuclear or mitochondrial infections.

Hypothesis: A cytosolic virus triggers the TH pathway with il-2 primed CTL which uses Fas to destroy cells.  This can be seen in Type one diabetes where the cytosolic flu virus can trigger the disease,  The nuclear virus HBV triggers the the Tc pathway where il-21 primes the CTL to kill using it's TCR which looks into the MHC1 of cells. This Tc pathway also involves TH17 cells to pop the nuclear membrane with il-26 and then il-17F to call CTL.

Type 1 diabetes, CTL and fas
https://www.ncbi.nlm.nih.gov/pubmed/15466911
http://diabetes.diabetesjournals.org/content/51/5/1391

Flu virus, fas CTL
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1143766/

CTL and fas
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088981/

Fas binding induces apoptosis

Granzyme A and apoptosis CTL induced death
http://jcb.rupress.org/content/167/3/457

CTL killer with granzyme B
https://retrovirology.biomedcentral.com/articles/10.1186/1742-4690-9-S2-P13

Platelets mediate CTL in HBV liver damage
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908083/1

platelets contain TGF-b1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271718/

TLR9 and HBV
https://www.ncbi.nlm.nih.gov/pubmed/24942353

TLR9 /TGF-b1 pathways and blood
https://www.ncbi.nlm.nih.gov/pubmed/28356164

Th17 and HBV induced liver damage
https://www.ncbi.nlm.nih.gov/m/pubmed/28731149/

TBF-b1and Th producing il-21
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0064612

il-21 and CTL TCR
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042849/

il-21 and granzyme B
https://www.sciencedirect.com/science/article/pii/S0022202X17313106

il-2 increases all 3 granzyme A,B, and C
http://www.jimmunol.org/content/175/12/8003

unless il-5 triggers the monomer version of IgA the hormones appear to dictate