Monday, February 25, 2013

cross targeting causes autoimmunity

Hypothesis:

Cross targeting is when 2 different infections cause antibodies to target the same self protein.  Often times the first infection, a bacterial or fungal infection causes a build up of antibodies including the molecular mimicry type antibodies, the auto-antibodies.   For example,  E.coli breaking down red blood cells makes bilirubin like the liver. It is easy to imagine antibodies would start flagging the liver for attack but the body's immune system holds back.   Then a second infection creates a similar antibody by infecting the organ itself, like hepatitis C.  It is this cross targeting that I believe causes the development of autoimmune disease.  When the immune system now has another reason to attack one's own body, in this example the liver resulting in autoimmune liver disease.

Sutterella the bacterial culprit of autism has an omega fat coat much like our nerves, antibodies against nerves develop, then the measles vaccine which is known to cause antibodies against nerves...would cause cross targeting of the immune system.

Schizophrenia hallucinations could be T.gondi  induced through PAN/apple domains toward the NMDA receptor and i believe that the Bona virus or herpes virus would have to infect the brain cell to trigger the autoimmune disease. That the immune system itself causes the schizophrenia by attacking the receptor.  (the ME49 strain of T. gondi is dimorphic) 

Hypothesis: it is not one infection that induces autoimmune disease but the cross targeting of 2.  A bacterial/fungal followed by a secondary viral one...or vaccine.

Added thoughts on March 6:  After a flu epidemic cases of Type 1 diabetes increases. The flu virus incubates and divides in the pancreas (according to Italian turkeys).
 http://www.ncbi.nlm.nih.gov/pubmed/?term=Ilaria+Capua+pancreas 
Swine flu H3n2 is one of the viruses that would infect the pancreas and cause diabetes.

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