Friday, September 21, 2012

Update on the theory:

 I have the most figured  out for celiac disease.  I have been dragging my feet about posting what I know only because I was hoping to find the last piece of the puzzle first.  I don't have the gluten piece, the most critical piece and the last piece i need.

Celiac disease has been associated with a history of bladder infections.  The most common cause of bladder infections is a form of e.coli that is dimorphic in that it shifts between a rod morphology and a long filament morphology.

The enzyme responsible for the long morphology is called LON (long with the g dropped off). LON is a serine protease. Casein is not just a substrate but a stimulator of the LON enzyme.

The action of casein on LON could explain why hycase solutions which contains casein causes e. coli to change morphology.  (not all e.coli just some varients)

This leads me to ponder does gluten which is similar in structure to the casein protein act on LON in a similar fashion causing the morphology change of e.coli? Perhaps gluten causes an even stronger activation of LON?

I am trying to either go back to immunology school or find a lab willing to test this out for me.  This could explain the early stage of autoimmune disease where the antibodies are building up.  The infection changing morphologies is confusing the immune system. In some people the immune system is grabbing the gluten trigger because the infection keeps disappearing.

Once a person has developed a hyper antibody state a virus could easily push the immune system into a misguided attack.

What is elegant about this theory is that it could be also applied to autism.  The gluten casein pattern of sensitivity has been discussed for them and the sutterella bacteria that has been a suggested culprit is dimorphic.   Does the LON enzyme control it's morphology? Do the only kids who react to the viral vaccines already have the antibodies built up from sutterella switching morphologies? Is autism really an autoimmune disease of the brain?

This is where i am at now.  This is what we have to figure out.  I am optimistic. We just need to look at gluten and e.coli next.

I hope someone out there reads these and can understand me. Even better can someone out there test this out and give me an answer?

Angela Biggs






1 comment:

  1. For someone with a gluten intolerance, would there be a way for us to test this out for you? I also have a few other friends with celiac/intolerances who I could maybe convince to try things out too. This all just makes too much sense to me to not want to see what I can do!

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