Myasthenia gravis, Brown's syndrome, Still's disease, and mycoplasmas

Brown's syndrome and Myasthenia gravis 
http://www.ncbi.nlm.nih.gov/pubmed/8368187

Eye muscle antibodies in MG
http://www.ncbi.nlm.nih.gov/pubmed/9646837

mycoplasma and MG
http://www.ncbi.nlm.nih.gov/pubmed/18506483

my previous post about MG (2 types)
http://angelabiggs.blogspot.com/2016/01/updated-autoimmune-cross-targeting-and.html

stills disease and brown's
http://www.ncbi.nlm.nih.gov/pubmed/3625648

Still's disease and mycoplasma
http://cid.oxfordjournals.org/content/32/6/e105.full.pdf

JIA is often called the adolescent still's disease
https://en.wikipedia.org/wiki/Juvenile_idiopathic_arthritis

juvenile idiopathic arthritis JIA
http://www.ncbi.nlm.nih.gov/pubmed/12878798

JIA, brown's, and tendons
http://www.ncbi.nlm.nih.gov/pubmed/3981317

Chick tendons and mycoplasmas
http://www.ncbi.nlm.nih.gov/pubmed/7340082

Area Postrema and autoimmunity: Is neuromyelitis optica caused by cross-targeting here?

Hypothesis: autoimmunity is triggered by the cross-targeting of a virus marking the inside of the cell and an infection marking the outside.  One of each. If Neuromyelitis optica is autoimmune then the flu virus and either a fungus or mycoplasma will be found triggering it. 

The Area postrema is responsible for nausea and this area of the brain could be the "target".

neuromyelitis optica with lesions in the area postrema causes hiccups, nausea, vomiting
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068006/

The average time to development of these lesions after the first brain symptom was 21 months!
http://www.hindawi.com/journals/msi/2012/735486/
fi they look too soon they may not see lesions

In fact brazilian study found lesions only 50% of the time
http://www.ncbi.nlm.nih.gov/pubmed/18392403

area posterma is located right next to brain stem

https://www.google.com/search?q=area+postrema+located&espv=2&tbm=isch&imgil=WIYf19aj099DLM%253A%253BT801LTbqdDA5OM%253Bhttps%25253A%25252F%25252Fwww.cnsforum.com%25252Feducationalresources%25252Fimagebank%25252Fserotonergic%25252F5ht3_dist&source=iu&pf=m&fir=WIYf19aj099DLM%253A%252CT801LTbqdDA5OM%252C_&usg=__fgW1dXHt6Efd47emxF1_5BHEHxk%3D&biw=1050&bih=717&ved=0ahUKEwili8SS7JHNAhUIb1IKHWTfCbsQyjcISw&ei=iZtUV-WiJ4jeyQLkvqfYCw#imgdii=WIYf19aj099DLM%3A%3BWIYf19aj099DLM%3A%3BAPviZeI-_6D-AM%3A&imgrc=WIYf19aj099DLM%3A

Area postrema and D2 receptors
http://www.sciencedirect.com/science/article/pii/0014299981905409

Swine flu family viruses are linked to D2 receptors in previous post
http://angelabiggs.blogspot.com/2016/05/dopamine-receptors-and-flu-viruses-are.html

D2 receptors are on the pancreas which means a risk of type one Diabetes at the same time
http://www.ncbi.nlm.nih.gov/pubmed/16129680

swine flu is H1N1 which is influenza A

my previous post on neuromyelitis: connects influenza A with 2 types of infection
http://angelabiggs.blogspot.com/2014/08/neuromyelitisoptica-and-cross-targeting.html

interesting article: mycoplasma, NMO, and anti-aquaporin
http://www.ncbi.nlm.nih.gov/pubmed/19497587
(pneumonia)

There seem to be 2 types of NMO: monophasic and relapsing

Is the monophasic neuromyelitis optica type trigger by mycoplasms with the flu? it effects both sexes equally
https://www.researchgate.net/publication/5292135_Mycoplasma_pneumonia_as_a_cause_of_neuromyelitis_optica

The relapsing neuromyelitis optica affects woman more and has "waves " of attacks which sounds like a fungal infection. Estrogen can alter the morphology of fungal infections. (mold to yeast transitions where mold forms "disappear")

Does the fungal or mycoplasma infection create aquaporin antibodies? Can the antibodies alone trigger the autoimmune disease with a flu virus? Aquaporin proteins of the human body are highest in the CNS that are targeted in NMO.

If this is true then it means another infections like t.gondii or strep can open up the blood brain barrier which allowed the flu virus and the aquaporin antibodies in. (normally viruses and antibodies cannot reach the brain)

Is that why this disease is rare? 3 infections needed? Or can fungal infections cross the blood brain barrier which means that the remitting NMO is more common? more woman have this disease?

dicord lupus and nmo (Trichophyton)
http://www.ncbi.nlm.nih.gov/pubmed/19745613
http://www.ncbi.nlm.nih.gov/pubmed/11036404

sjogren's and nmo (candida)
http://www.ncbi.nlm.nih.gov/pubmed/26938585
http://www.ncbi.nlm.nih.gov/pubmed/21844143

aspergillus and NMO
http://www.ncbi.nlm.nih.gov/pubmed/27031126

mycoplasmas and NMO
http://www.ncbi.nlm.nih.gov/pubmed/18563469

Mycoplasmas (RA) and biofilms
http://www.ncbi.nlm.nih.gov/pubmed/16549656
http://www.ncbi.nlm.nih.gov/pubmed/19443045

candida and biofilms
http://mic.sgmjournals.org/content/157/11/3232.full.pdf

in yeast aquaporins help biofilms form
http://www.sciencedirect.com/science/article/pii/S0304416513004121

candida and aquaporins
http://aem.asm.org/content/71/10/6434

NMO has anti-aquaporins
http://www.ncbi.nlm.nih.gov/pubmed/17439296

specifically aquaporin4 is the water channel of the central nervous system and the specific channel in NMO that has antibodies against it
http://www.nature.com/nrn/journal/v14/n4/full/nrn3468.html

Further: Can crystal meth replace the virus triggering the autoimmune cross-targeting? Are users at risk of developing NMO?

Note that 10-15% of NMO cases do not have aquaporin antibodies or lesions so in a small percent something is replacing the mycoplasmas and fungal infections.
http://www.ncbi.nlm.nih.gov/pubmed/26950113

Sexes affected equally when no aquaporin antibodies yet NMO
http://www.ncbi.nlm.nih.gov/pubmed/23658379

A small group of NMO have been associated with ulcerative colitis

I had associated c.soridella with ulcerative colitis (a relative of c. difficile that secretes an acid similar to h.pylori thus causing the ulcers)
http://angelabiggs.blogspot.com/2013/05/ulcerative-colitis.html

C.diff or C. sordellii secrete a Toxin B that effects water channels (aquaporins)
http://www.ncbi.nlm.nih.gov/pubmed/12640036
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250724/

Could the group negative for the antibodies be the group triggered by the ToxinB? 

Carcinogens using receptors to enter cells

Francis Peyton Rous' Co-carcinogenesis hypothesis: that a virus and a carcinogen together cause cancer. (1966 Nobel prize for HPV work) The co-carcinogenesis hypothesis was published in 1944  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135410/

My co-carcinogenesis takes his further because carcinogens inhibit polymerases.

(yes we have been told carcinogens cause DNA damage but I think their ability to inhibit polymerases causes most cancer. The cancers have patterns, cancer families, and are not that chaotic)

Alone a carcinogen would inhibit growth of the cell until a virus appears opens up the DNA and modifies the cell to create virus supplies for ever.  The problem is the carcinogen inhibits the viral polymerase better than the human polymerase.  So instead of the virus making what it wants the infected cell is transformed into a cancer cell.

Different carcinogens are absorbed by different areas of the body through receptors. Viruses also use receptors.

Estrogen receptors: Benzene/phenols and herpes viruses

https://academic.oup.com/toxsci/article/54/1/138/1670624/The-Estrogen-Receptor-Relative-Binding-Affinities

Estrogen receptors: heptachlor

https://books.google.com/books?id=utm6BQAAQBAJ&pg=PA195&lpg=PA195&dq=heptachlor+estrogen+receptor&source=bl&ots=Ivpog3RvK2&sig=GeZodD2n7fKnjxqlUEz6yoqPfnA&hl=en&sa=X&ved=0ahUKEwinzL-g1I7TAhUlHGMKHRFCBJwQ6AEINjAD#v=onepage&q=heptachlor%20estrogen%20receptor&f=false

Melanocortin receptors/ estrogen receptors:  Organochlorides and flaviviruses/herpes

https://books.google.com/books?id=n_tXscNndysC&pg=PA86&lpg=PA86&dq=Organochlorines+bind+receptors&source=bl&ots=MCUZ54oDQ2&sig=GVoiK-Hwc__98Z1v2q-PdDLaFDY&hl=en&sa=X&ved=0ahUKEwj3oL28047TAhVCxFQKHXXEBasQ6AEIJjAC#v=onepage&q=Organochlorines%20bind%20receptors&f=false

Acetylcholine receptors: nitrates/nitrites and enteroviruses

https://www.ncbi.nlm.nih.gov/pubmed/15551380

Gaba receptors: alcohol

http://www.pnas.org/content/103/22/8307.full

gaba receptors are found in pancreatic as well as nerves
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217445/

Dopamine receptors: flu virus

dopamine receptors are found in pancreatic cells
http://www.jbc.org/content/280/44/36824.long

I have only matched these carcinogens and viruses through receptors.  I am just suggesting these have a higher likelihood of causing cancer together because they tend to pick the same cells. However a carcinogen and a virus can use different paths to get into the same cell. (they don't have to use the same receptor as I have shown with pancreatic cancer)

Possible???

Acetylcholine receptors, nitrates/nitrites, enteroviruses, and cancer

Logically cells that involve acetylcholine receptors would end up with nitrates and nitrites in them. Have the carcinogen there does not cause cancer until a virus infects the same cell.

Enteroviruses look like they infect using the same acetylcholine receptors
http://angelabiggs.blogspot.com/2015/07/enteroviruses-and-acetylcholine.html

Only when both are there does co-carcinogenesis occur resulting in cancer.

Co-carcinogenesis : Rous' hypothesis requires a virus and a carcinogen together to start cancer.

My co-carcinogenesis takes his further:  Carcinogens inhibit polymerases.

(yes we have been told carcinogens cause DNA damage but I think their ability to inhibit polymerases causes most cancer. The cancers have patterns and are not that chaotic)

Alone a carcinogen would inhibit growth until a virus appears opens up the DNA and modifies the cell to create virus supplies for ever.  The problem is the carcinogen inhibits the viral polymerase better than the human polymerase.  So instead of the virus making what it wants the infected cell is transformed into a cancer cell.

Different carcinogens are absorbed by different areas of the body. The post suggests that nitrates/nitrites are taken up by acetylcholine receptor cells.

sh groups and acetylcholine
http://www.sciencedirect.com/science/article/pii/0014579377800549

nitrates,vascular muscle relaxation and sh groups
http://www.ncbi.nlm.nih.gov/pubmed/6816463

acetylcholine is a neurotransmitter
http://www.ncbi.nlm.nih.gov/books/NBK11143/

hot dogs and brain tumors in children and pancreatic cancer in adults
http://www.processedfreeamerica.org/resources/health-news/355-hot-dogs-cause-brain-tumors-in-children

Pancreas and acetylcholine receptors
http://www.pnas.org/content/107/40/17397.full.pdf

Gastric cancer and nitrates? it is being debated
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690057/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2062934/

gastric chief cells and acetylcholine
https://en.wikipedia.org/wiki/Regulation_of_gastric_function

coxsackie infection blocked by nicotine
http://www.ncbi.nlm.nih.gov/pubmed/26851533

How is Amyotrophic lateral sclerosis, vit D, Tau protein, and organochlorides connected?

Organochlorides can cause parkinson's and cancer by infected melanoma containing cells but they have also been linked to cases of ALS. How? Does the cl- bind vit D channels like aflatoxin? Does it then bind hsp70? is that how they are linked to the creation of Tau ?


Is ALS triggered by aflatoxin like compounds and tau is produced? Previous post i am building on.
http://angelabiggs.blogspot.com/2016/05/amyotrophic-lateral-sclerosis-and.html

aflatoxin binds the Vit D receptor
https://www.citeab.com/publication/1455664-25483621-toxicity-of-aflatoxin-b1-towards-the-vitamin-d-rece

Tau has been found to be reduced with vit D supplementation
http://www.ncbi.nlm.nih.gov/pubmed/24412233

organochloride pestides and vit D deficiency
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266254/

some forms ALS caused by organochlorides
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358481/

Vit D has been shown to slow the progression of ALS
http://www.ncbi.nlm.nih.gov/pubmed/24428861

do organochlorides bind the vit D receptor as well as the melatonin receptor?

note that the vit D receptor controls the Chloride channel
http://www.ncbi.nlm.nih.gov/pubmed/21659475

Does Cl bind these particular vit D receptors as a form of feed back regulation?

note that the organochloride "dieldrin" causes Tau protein

https://books.google.com/books?id=otQw-eo1aA0C&pg=PT314&lpg=PT314&dq=organochlorine+tau+protein&source=bl&ots=N0XaZ3LiGA&sig=tVcc99MHxHBAKZYaecytuMAY8HU&hl=en&sa=X&ved=0ahUKEwj8xIzcw4rNAhViE1IKHW18BKcQ6AEITzAH#v=onepage&q=organochlorine%20tau%20protein&f=false

Dieldrin creates the amyloid protein by destroying the mitochondria too.

organochlorides, alzheimer's, and amyloid
http://angelabiggs.blogspot.com/2016/06/is-reason-chlordane-triggers-alzheimers.html

further are there high levels of vit D receptors in breast tissue and could this explain why so much heptachlor is stored there?
http://www.ncbi.nlm.nih.gov/pubmed/7881099

note that Vit D cycles to the cytosol where it binds a type of hsp70
http://www.reactome.org/content/detail/209766

Hsp70 is known to bind tau
http://www.ncbi.nlm.nih.gov/pubmed/20308058
http://www.ncbi.nlm.nih.gov/pubmed/25882706

an imbalance of hsp70 family proteins causes tau accumulations!
http://www.ncbi.nlm.nih.gov/pubmed/23271055

Does aflatoxin or dieldrin bind not just to the vit D receptor but once in the cytosol do they bind the hsp70? is this why aflatoxin causes microtubule issues?

cells treated with aflatoxin increase expression of hsp70
http://www.ncbi.nlm.nih.gov/pubmed/15037034

previous aflatoxin post
http://angelabiggs.blogspot.com/2016/04/what-does-aflatoxin-do-mitochondria-of.html

like heptachlor does aflatoxin increase the risk of breast cancer? maybe
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567057/

Benzene, the carcinogen, binds estrogen receptors

Benzene and estrogen receptors
http://www.ncbi.nlm.nih.gov/pubmed/11137303

Benzene associated cancers: lymph and bone

Leukemia and benzene
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447593/

Benzene and breast cancer
http://www.ncbi.nlm.nih.gov/pubmed/19366049

note that the estrogen receptors of nerves cycle to the mitochondria instead of to the nucleus therefore Benzene doesn't cause cancer at nerves.

Does benzene cause damage to the mitochondria of nerves since it is going there?

Exposure to the solvents like benzene has been found to be a risk factor for Alzheimer's
http://www.ncbi.nlm.nih.gov/pubmed/7771442

alzheimer's and the mitochondrial damage of neurons
http://angelabiggs.blogspot.com/2015/08/alzheimers-and-dysfunctional.html

Does benzene cause cancers that involve cells with estrogen receptors?

Does chlordane trigger Alzheimer's because it destroys the mitochondria? why does chlordane and heptane prefer melatonin containing cells?

Previously heptachlor was found to trigger parkinson's
http://www.aboutlawsuits.com/milk-parkinsons-disease-study-91199/

I suggested this was because the heptachlor can replace the virus in the autoimmune cross-targeting hypothesis.
http://angelabiggs.blogspot.com/2015/12/not-just-flu-but-flaviviruses-and.html

Now in addition to parkinson's disease chlordane and heptachlor have been associated with Alzheimer's. What is happening? I have previously suggested that Alzheimer's is caused by damaging the mitochondria of nerves.
http://angelabiggs.blogspot.com/2015/08/alzheimers-and-dysfunctional.html

cis-chlordane 5X increase in Alzheimer's
http://www.alzforum.org/news/research-news/pesticides-raise-risk-als-and-potentially-alzheimers-disease

chlordane and heptachlor are closely related
https://en.wikipedia.org/wiki/Chlordane

chlordane and heptachlor and the rat liver
https://www.jstage.jst.go.jp/article/joma1947/102/11-12/102_11-12_1345/_article

heptachlor destroys the mitochondria
http://www.ncbi.nlm.nih.gov/pubmed/23867817

Heptachlor can induce parkinsonism by killing the NS cells
http://www.ncbi.nlm.nih.gov/pubmed/24577234

Chlordane effects the nervous system by damaging the mitochondria of the nerves

This is separate from it's ability to cause cancer with a virus where the viruses polymerase is inhibited much like chlorine does.

Heptachlor has been associated with prostate cancer where it could be inhibiting the polymerase of flaviviruses . Does it increase melanoma in those exposed to pesticide and flaviviruses?

Melanoma was thought to be connected to heptochlor
https://books.google.com/books?id=h70DCwAAQBAJ&pg=PA23&lpg=PA23&dq=organochlorine+insecticides+melanoma&source=bl&ots=-HtNZpW9xJ&sig=hj740xTOwAWDUqkaOsjmnlRbVc8&hl=en&sa=X&ved=0ahUKEwi1xf3H2InNAhVPTFIKHetDDGUQ6AEITjAI#v=onepage&q=organochlorine%20insecticides%20melanoma&f=false

But then a "take home questionnaire" saw no connection
http://www.ncbi.nlm.nih.gov/pubmed/17096337

It would be nice to have a more scientific study to be done because the higher rates of melanoma and working with pesticides is real
http://www.scientificamerican.com/article/farm-pesticides-linked-to-skin-cancer/

Is heptachlor and chlordane attracted to melatonin containing cells?

Melatonin is said to control the secretion of Cl-
http://jpet.aspetjournals.org/content/352/1/119.full

can Cl- bind the receptors as well as melatonin ? Is chlordane or heptachlor binding melatonin receptors? We can see it in the same cell tissues as flaviviruses which I suspect use melanocortin receptors.