Is lichen planus autoimmune cross-targeting of HPV16 and trichophyton?

Autoimmune cross-targeting hypothesis

The layering of 2 different infections on one target triggering autoimmune disease.  A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria infection marking the outside.

Is lichen planus autoimmune cross-targeting of HPV16 and trichophyton? 

Lichen planus and trichophyton schoenleinii
https://www.researchgate.net/publication/234085237_Pitfall_scarring_alopecia_Favus_closely_mimicking_lichen_planus

Lichen planus and HPV
http://www.pasteur.fr/en/institut-pasteur/press/press-documents/human-papillomavirus-linked-auto-immune-disease
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075460/
http://www.ncbi.nlm.nih.gov/pubmed/25256345
http://www.ncbi.nlm.nih.gov/pubmed/21528036

How does tinea captis overlap with lichen planus? Just location? when the fungus causes loss of hair on the head?

tinea capitis and trichophyton schoenleinii
http://www.ncbi.nlm.nih.gov/pubmed/17992453

tinea captis and trichophyton tonsurans
https://www.researchgate.net/publication/16724647_Lupus_Erythematosus_like_Tinea_Capitis_caused_by_Trichophyton_Tonsurans

note that tinea captis is the specific type of alopecia (hair loss) that is caused by fungus?

Previously i had looked at alopecia as an autoimmune disease cross-targing of trichophyton and flaviviruses (west nile or hepatitis C)
http://angelabiggs.blogspot.com/2015/05/updated-alopecia-as-autoimmune-disease.html

Francis Peyton Rous' Co-carcinogenesis hypothesis: that a virus and a carcinogen together cause cancer. (1966 Nobel prize for HPV work)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135410/

What I surmise from his hypothesis:

A virus enters a cell through a receptor, opens up and alters host DNA telomeres. The carcinogen  inhibits the virus' polymerase because viral polymerases have stronger binding affinities than the host's.

Cancer cells can make unlimited copies because of the telomere modifications done by the virus. 

There are DNA polymerases and RNA polymerases. Think of DNA as the cookbook and RNA as recipes...one polymerase copies the entire cookbook, one makes repairs, and one polymerase copies just a recipe.

If the viral polymerases are inhibited by the carcinogen instead of the host's polymerase then the cancer "stem" cell could be created.  The host's polymerases have access to and can make unlimited copies.

Oral cancers:  HPV and alcohol/tobacco

http://www.ncbi.nlm.nih.gov/pubmed/21330164

connection between lichen planus and oral cancer could be the HPV
http://www.ncbi.nlm.nih.gov/pubmed/10527601

Is lichen sclerosis caused by autoimmune cross-targeting of spirochetes and HPV16?

Autoimmune cross-targeting hypothesis

The layering of 2 different infections on one target triggering autoimmune disease.  A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria infection marking the outside.

Lichen sclerosis trigger by autoimmune cross-targeting of a spirochete and HPV.

spirochetes and lichen sclerosis
http://www.ncbi.nlm.nih.gov/pubmed/2393064
http://www.ncbi.nlm.nih.gov/pubmed/3192771
http://www.ncbi.nlm.nih.gov/pubmed/10792212
I can't tell if this is truly the lyme spirochete or not.

Penile lichen sclerosis and  hpv16
http://www.ncbi.nlm.nih.gov/pubmed/16796627

Penile cancer and lichen sclerosis (the overlap is the virus)
http://www.ncbi.nlm.nih.gov/pubmed/10570372
http://www.ncbi.nlm.nih.gov/pubmed/16515998
http://www.actasdermo.org/en/lichen-sclerosus-squamous-cell-carcinoma/articulo/S1578219012000479/

HPV16 and penile cancer
http://www.webmd.com/cancer/news/20090824/hpv-infections-linked-to-penile-cancer
http://www.ncbi.nlm.nih.gov/pubmed/23474228
http://www.ncbi.nlm.nih.gov/pubmed/18047520 and lichen sclerosis

Talc is a carcinogen.  Use in the penile region during and hpv infection could cause cancer.

Francis Peyton Rous' Co-carcinogenesis hypothesis: that a virus and a carcinogen together cause cancer. (1966 Nobel prize for HPV work)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135410/

What I surmise from his hypothesis:

A virus enters a cell through a receptor, opens up and alters host DNA telomeres. The carcinogen  inhibits the virus' polymerase because viral polymerases have stronger binding affinities than the host's.

Cancer cells can make unlimited copies because of the telomere modifications done by the virus. 

There are DNA polymerases and RNA polymerases. Think of DNA as the cookbook and RNA as recipes...one polymerase copies the entire cookbook, one makes repairs, and one polymerase copies just a recipe.

If the viral polymerases are inhibited by the carcinogen instead of the host's polymerase then the cancer "stem" cell could be created.  The host's polymerases have access to and can make unlimited copies.

Morgellon's filaments and spirochetes
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257881/
http://www.ncbi.nlm.nih.gov/pubmed/25879673
http://www.ncbi.nlm.nih.gov/pubmed/24715950
http://www.ncbi.nlm.nih.gov/pubmed/16489838
http://www.ncbi.nlm.nih.gov/pubmed/23326202
http://www.ncbi.nlm.nih.gov/pubmed/22253541

specifically morgellon's could be Borrelia garni
http://bmcdermatol.biomedcentral.com/articles/10.1186/s12895-015-0023-0

Looking for things that kill spirochetes or H.pylori

Brassicaceae : mustards, mustard flowers, the crucifers, or the cabbage family.
https://en.wikipedia.org/wiki/Brassicaceae

The sulforaphane of the brassicaceae of this family inhibits protein synthesis in cancer cells? but no effect on non cancer cells?
http://www.ncbi.nlm.nih.gov/pubmed/22640870

sulforaphane kills spirochetes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC296232/

broccoli sprouts against spirochetes
http://www.ncbi.nlm.nih.gov/pubmed/22359278
http://www.ncbi.nlm.nih.gov/pubmed/20459098
http://www.ncbi.nlm.nih.gov/pubmed/20658571
http://www.ncbi.nlm.nih.gov/pubmed/19349290
http://www.ncbi.nlm.nih.gov/pubmed/18484523
https://en.wikipedia.org/wiki/Broccoli_sprouts

Horseradish and mustard oil?

H.pylori is related to campylobactera not spirochetes but maybe they are similar?

Wasabi and h.pylori
http://www.ncbi.nlm.nih.gov/pubmed/15246236

Completely different plant family

licorice and h.pylori
http://www.ncbi.nlm.nih.gov/pubmed/12127165
http://www.ncbi.nlm.nih.gov/pubmed/25276073

What can kill bacteria can also cause allergic reactions:

About 10-15% of people have severe reactions to poison ivy, poison oak, or mangos.  All of these contain ursurhiol.  It is my contention that this people have a spirochete infection.  The infection reacts when it is killed by ursurhiol.

http://www.ncbi.nlm.nih.gov/pubmed/15701120
http://www.ncbi.nlm.nih.gov/pubmed/15606656
http://www.ncbi.nlm.nih.gov/pubmed/22053296
http://www.ncbi.nlm.nih.gov/pubmed/15485071


The  Helicobacter pylori can be killed by ursurhiol
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826732/

Ursurhiol is the irritant in poison ivy, poison oak, poison sumac, and mango skins
https://en.m.wikipedia.org/wiki/Urushiol

Is ursurhiol stronger than mustard seed, broccoli sprouts, horseradish or wasabi?

Lambert-eaton myasthenic syndrome and autoimmune cross-targeting with asbestos

Autoimmune cross-targeting hypothesis

The layering of 2 different infections on one target triggering autoimmune disease.  A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria infection marking the outside.

For Lambert-eaton myasthenic syndrome the autoimmune cross-targeting starts at the lungs with an enterovirus marking the inside of the lung cell and asbestos marking the outside (replacing the large infection as foreign) 

lambert-eaton myasthenic syndrome LEMS: aceytlcholine receptors involved

http://emedicine.medscape.com/article/1170810-overview

Enteroviruses (d68, coxsackie) use Acetlycholine receptors 

Generalized MG (trunk, arms and legs are weak)

Examples of enteroviruses : d68, coxsackie viruses, polio virus, and  echoviruses

polio virus and thymus
http://www.ncbi.nlm.nih.gov/pubmed/20368632

Acetylcholine receptors, thymus and myasthenia gravis
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1536815/
http://www.ncbi.nlm.nih.gov/pubmed/182897

40% of LEM have cancer with it

http://emedicine.medscape.com/article/1170810-overview

non polio enterovirus like d68 infects the lungs

http://www.lung.org/about-us/media/press-releases/american-lung-association-Enterovisus-statement.html?referrer=https://www.google.com/

small lung cancer and asbestos

http://www.asbestos.com/cancer/lung-cancer/

Could this be autoimmune cross-targeting of asbestos and an enterovirus in the lungs? Occurring ontop of the cancer???

Does asbestos cling to the voltage gated calcium channels?

asbestos binds sialic acid

http://www.ncbi.nlm.nih.gov/pubmed/6312192

sialic acid binds sodium gated voltage channels

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217074/

does it bind the same way for the calcium channel? Can this trigger the outside part of cross-targeting autoimmunity?

calcium channels of the heart involve sialic acid
http://www.ncbi.nlm.nih.gov/pubmed/2438678
http://www.ncbi.nlm.nih.gov/pubmed/2420406
verapamil a calcium channel blocker appears to work using sialic acid

so while some of the asbestos is inhibiting the viral polymerase causing cancer...some of the asbestos is bound to the outer membrane at the calcium channels through sialic acid?

Asbestos inhibiting polymerases
http://www.ncbi.nlm.nih.gov/pubmed/21543585

Here is the earlier blog post connecting mesothelioma, adenoviruses, and asbestos
http://angelabiggs.blogspot.com/2015/12/mesothelioma-and-co-carcinogenesis.html

note that for the small cell lung carcinoma it is the enteroviruses (maybe i slightly different group of cells infected?)

curcumin inhibits the replication of human enterovirus 71

http://www.sciencedirect.com/science/article/pii/S2211383514000586



Does this work on other enteroviruses? 

Are there 2 types of pick's disease in Japan because of the use of Aspergillus oryzae?

This is a continuation of an older post connecting tau to
http://angelabiggs.blogspot.com/2016/03/microtubule-disease-issues-aflotoxin.html

japan's pick's disease
http://www.ncbi.nlm.nih.gov/pubmed/10935442

2 subtypes of pick's disease
http://www.ncbi.nlm.nih.gov/pubmed/12457075

is this because they have 2 types of aspergillus?
Aspergillus oryzae which is used to make soy sauce etc. is an obvious choice

and then which: Aspergillus fumigatus, Aspergillus flavus, Aspergillus terreus or Aspergillus niger ?

Aspergillus fumigatus is the most common in japan like europe
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256053/
http://www.ncbi.nlm.nih.gov/pubmed/24751235

Does aspergillus cause tau proteins because of aflatoxin?
http://angelabiggs.blogspot.com/2016/04/what-does-aflatoxin-do-mitochondria-of.html

Dopamine receptors and the flu viruses: are flu viruses using them as door knobs to enter cells

There are 5 types of dopamine receptors
http://www.livestrong.com/article/141471-5-types-dopamine-receptors/

The flu virus has an affinity for dopamine cells
http://www.ncbi.nlm.nih.gov/pubmed/23251423

The blog post is going to make the hypothesis that flu viruses are using dopamine receptors as door knobs to enter cells and that the viruses have different affinities for them.  Imagine one door they open 90% of the time based on binding affinities and the rest 10%....but in reality is I don't know.

D2 receptors are connected to the movement disorders while the D4s are not based on antipsychotic drugs?   Haloperidol can trigger movement disorders through D2 while clozapine doesn't. Clozapine has a higher affinity for D4 receptors and stimulates those cells.

D4 receptors are found in the heart. D2 receptors on the other hand are found on the pancreas.

antibodies to D2 where found in Acute onset Pandas with "small choreiform movements" but not in the pandas-like chronic tics
http://www.ncbi.nlm.nih.gov/pubmed/26454143


Type A  Bird Flu and D4 (flu uses this receptor and destroys these cells) 

Flu virus attacking heart : bird flu H5N1and D4
http://www.mayoclinic.org/diseases-conditions/bird-flu/basics/complications/con-20030228
http://www.ncbi.nlm.nih.gov/pubmed/26552130
http://www.dailymail.co.uk/health/article-2795370/schoolgirl-12-dies-flu-virus-attacked-heart.html

Note that the bird flu leaves people at increased risk for parkinson's disease
https://nwpf.org/stay-informed/news/2009/08/bird-flu-virus-strain-leaves-survivors-at-increased-parkinson%E2%80%99s-disease-risk/

humans and birds use of dopamine to create vocalizations
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362661/

note that the spanish flu of 1918 which was linked to parkinson's is genetically similar to the current day bird flu
http://news.nationalgeographic.com/news/2005/10/1005_051005_bird_flu.html



Most PANDAS have been connect to H1N1...by parents? Looking for references connecting D4.

Swine Flu and D2 : swine flu H3N2

Flu virus and pancreatic cells:  H3N2 or H1N1 and D2 on the pancreas
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536404/
https://www.newscientist.com/article/dn22456-diabetes-linked-to-flu/
http://jvi.asm.org/content/87/1/597.full

Note that it was the swine flu H3N2 vaccine that triggered the narcolepsy
http://www.cdc.gov/vaccinesafety/concerns/history/narcolepsy-flu.html

interestingly the D2 receptors are down regulated in sleep deprivation
http://www.ncbi.nlm.nih.gov/pubmed/22573693

Clozapine alters sleep cycles
http://www.ncbi.nlm.nih.gov/pubmed/15085087

 Do kids with PANDAS have narcolepsy? some do.

http://www.movementdisorders.org/MDS/Journals/Clinical-Practice-E-Journal-Overview/Movement-Disorders-Clinical-Practice-E-Journal-Volume-1-Issue-4/Remitting-Tics-and-Narcolepsy-Overlap-Associated-with-Streptococcal-Infection-A-Case-Report.htm

narcolepsy and the hypothalamus cells...is this a specific unusual type of strep?
http://rarediseases.org/rare-diseases/narcolepsy/

How similar to D2 is D3? laughter and addiction are linked to D3
could the binding affinities be for both or slightly stronger for D3?

they seem similar in response to the antidepressant Tianeptine
http://www.ncbi.nlm.nih.gov/pubmed/11981225

kids with acute onset pandas have excessive eye movement and laughing
http://www.ncbi.nlm.nih.gov/pubmed/27166296

this paper talks about schizophrenia but what is important is the link between eye movement and the D3 receptor
http://www.ncbi.nlm.nih.gov/pubmed/11673801


H7N9 flu and D5

D5 is on the kidney

H7N9 and kidney issues
http://www.ncbi.nlm.nih.gov/pubmed/23992125
http://www.ncbi.nlm.nih.gov/pubmed/25579740
https://100dialysis.wordpress.com/2013/05/24/h7n9-kills-and-attacks-kidneys/

this flu can also trigger type one diabetes
http://jvi.asm.org/content/87/1/597.full


Neuroleptic malignant syndrome

The connection of the flu viruses, neuroleptic malignant syndrome, and dopamine receptors further validates that flu viruses are using dopamine receptors.

neuroleptic malignant syndrome has been found to develop when patients are given the anti-viral amantadine to combat brain flu virus encephalitis
http://www.ncbi.nlm.nih.gov/pubmed/11421428

This syndrome does not develop when the same anti-viral is given to combat west nile or other flaviviruses.  (which use melanocortin receptors)

Neuroleptic malignant syndrome appears to be connected to dopamine receptors
https://en.wikipedia.org/wiki/Neuroleptic_malignant_syndrome

note that the Haloperidol drug about that is known to use dopamine receptors also triggers neuroleptic malignant syndrome with combined with the anti-viral amantadine
http://www.ncbi.nlm.nih.gov/pubmed/2720007

Cerebral palsy: 4 types where 3 types are caused by infections

4 groups of cerebral palsy: neural migration, vascular clot issues, infections causing inflammation, and asphyxia during birth (abuse?)
http://www.ncbi.nlm.nih.gov/pubmed/7698521

Group one:  There is a neural migration group which could be the B.fragilis group. B. fragilis is the most common infection of amniotic

cerebral palsy and amniotic infections
http://www.ncbi.nlm.nih.gov/pubmed/26857522

premature birth is the strongest link to cerebral palsy
http://www.ncbi.nlm.nih.gov/pubmed/8513618

Bacteroides
https://en.wikipedia.org/wiki/Bacteroides

Looking at Bacteroides fragilis specifically
https://en.wikipedia.org/wiki/Bacteroides_fragilis

Bacteroides fragilis, the amniotic fluid,  and premature birth
http://www.ncbi.nlm.nih.gov/pubmed/2178562

B. fragilis toxin: causes the shedding of e-cadherin
http://jcs.biologists.org/content/120/11/1944

e-cadherin and neural migration
http://www.ncbi.nlm.nih.gov/pubmed/26823740

Could it be that the toxin made by this bacteria causes the neural migration issues ?

Group 2
The second largest group deals with vascular issues and blood flow to the brain: could the clotting issues be related to spirochetes in the mother? do these kids tend to have cleft palates or seizures?

Do spirochetes make high levels of cortisone? which spirochetes?

cleft palates and cerebral palsy
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675398/

cortisol and cleft palate
http://www.nature.com/nature/journal/v265/n5595/abs/265643a0.html

spirochetes and cortisol hypothesis: instead of inhibiting it overstimulates with it's toxin
http://angelabiggs.blogspot.com/2016/07/spirochetes-and-high-cortisol.html

the toxin could increase acetylcholine which could then increase cortisone

Acetylcholine and seizures
http://www.ncbi.nlm.nih.gov/pubmed/18333967

leptospirochetes hang out in the liver and kidneys

leptospirosis in children: jaunce, seizures
http://www.ncbi.nlm.nih.gov/pubmed/12450292

leptospirosis and acute febrile illness
http://www.ncbi.nlm.nih.gov/pubmed/16433137

seizures and cerebral palsy in newborns
http://www.seizure-journal.com/article/S1059-1311(02)00255-8/abstract

Can cortisone cause seizures? yes

Coritsone and seizures
http://www.ncbi.nlm.nih.gov/pubmed/7883666
http://www.ncbi.nlm.nih.gov/pubmed/15816945

H.pylori (spirochete) and cerebral palsy (older kids and adults)
http://www.ncbi.nlm.nih.gov/pubmed/18754923
but is this any higher than the general population?

 Group 3 could involve infections that exist the the cerebellum triggering and autoimmune attack of at the cerebellum.

This group overlaps autism.

sutterella and camyplobacteria infect the cerebellum

the meases virus (hence the vaccine) infects the cerebellum

Hypothesis: autoimmune disease can be triggered when simultaneous infections (or antibodies to infections) are focused on one target.  In this case the cerebellum when infected on the outside with a bacteria and then vaccine pieces bind and mark the inside of the cerebellum....the immune system attacks damaging this area of the brain.

Group 4 is physical damage to the brain causing permanent damage to the brain through asphyxia, a clot, accidents involving the head or even child abuse

Is Wegener’s granulomatosis caused by Autoimmune cross-targeting of h.pylori and polyomaviruses?

Autoimmune cross-targeting hypothesis

The layering of 2 different infections on one target triggering autoimmune disease.  A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria infection marking the outside.

wegener's vs. churg-strauss (both anca positive) these are similar
http://www.ncbi.nlm.nih.gov/pubmed/2189156

Kawasaki: mycoplasmas  & hepatitis B (and EBV too?): medium blood vessels

Takayasu: mycobacteria & hepatitis B/ polyomaviruses : large blood vessels

Churg-stauss: aspergillus & hepatitis B/ polyomaviruses : small blood vessels

Is Wegener's: polyomaviruses and h.pylori or spirochetes? small blood vessels

worms and churg-stauss? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1004078/

Bell's palsy and wegener's
http://www.ncbi.nlm.nih.gov/pubmed/15124173
http://www.ncbi.nlm.nih.gov/pubmed/11276335
http://www.ncbi.nlm.nih.gov/pubmed/10908974

bell's palsy and spirochetes
http://www.ncbi.nlm.nih.gov/pubmed/2589070Borrelia
http://www.ncbi.nlm.nih.gov/pubmed/1632233 Borrelia
http://www.ncbi.nlm.nih.gov/pubmed/365078 Syphilis
http://www.ncbi.nlm.nih.gov/pubmed/12284236 syphilis
http://www.ncbi.nlm.nih.gov/pubmed/25648561 Leptospira
http://www.ncbi.nlm.nih.gov/pubmed/21613003 Leptospira
http://www.ncbi.nlm.nih.gov/pubmed/15287387 Leptospira

H.pylori is not a spirochete but a relative of campylobacteria. (c. jejune and h.pylori can cause disease...are they similar to spirochetes in some ways?)

H.pylori and Wegener's
http://www.ncbi.nlm.nih.gov/pubmed/19218713

http://jpp.krakow.pl/journal/archive/12_08_s6/pdf/845_12_08_s6_article.pdf

https://www.researchgate.net/publication/24018101_Correlation_between_Helicobacter_pylori_infection_and_pulmonary_Wegener's_granulomacytosis_activity_J_Physiol_Pharmacol

JC virus and wegener's
http://www.ncbi.nlm.nih.gov/pubmed/14563468

BK virus and ANCA associated vasculitis
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142761/

Hepatitis B vaccine and Wegener's
http://www.reuters.com/article/dynavax-idUSBNG23616020090209

ANCA Vasculitis review paper
http://www.aafp.org/afp/2002/0415/p1615.html

 Polyomaviruses (JC virus/sv40, BK, hepatitis B) update: use Vit D receptors

serotonin and Vit D are connected
https://mcdb.colorado.edu/courses/4790/Autism.pdf

if vitamin D levels go up because the Vit D receptors are gone then two things can happen:
 a huge increase of serotonin and hypercalcemia

vit D caused hypercalcemia in Wegener's
https://www.ncbi.nlm.nih.gov/pubmed/9146687
https://www.ncbi.nlm.nih.gov/pubmed/8267026

note that cocaine use can cause a condition like Wegener's granulomatosis
http://www.sciencedirect.com/science/article/pii/S0025619611631005

serotonin B1 receptors have been implicated in the pleasure effects of cocaine
https://www.scripps.edu/newsandviews/e_20030929/parsons2.html

splenic infraction caused by the drug triptan (serotonin)
http://www.ncbi.nlm.nih.gov/pubmed/16767537

triptan is a serotonin antagonist that causes vasodilation by acting on serotonin B1
http://www.ncbi.nlm.nih.gov/pubmed/15853772

splenic infractions are seen with Wegener's granulomatosis
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389926/
http://www.ncbi.nlm.nih.gov/pubmed/17889260
http://www.ncbi.nlm.nih.gov/pubmed/10852290

odds are the spleen has serotonin B1 receptors too

Splenic infraction after cocaine use
http://annals.org/article.aspx?articleid=704463

serotonin B1 receptors
https://en.wikipedia.org/wiki/5-HT1B_receptor#Tissue_distribution_and_function

Amyotrophic lateral sclerosis and autoimmune cross-targeting: HPV and trichophyton concetricum? Or Aflatoxin caused?

Is ALS, amyotrophic lateral sclerosis, caused by autoimmune cross-targeting ? HPV and  Trichophyton concetricum ? 

My gut is telling me that these HPV vaccine triggered are cases are actually guillain barre and that the ALS is from the aflatoxin-like compound alone but because these cases were diagnosed as ALS it has to be kept open.

In the future it would be nice to varify that tau is there.

Tau protein as a marker for ALS

https://ftd.med.upenn.edu/uploads/media_items/phosphorylated-tau-candidate-biomarker-for-amyotrophic-lateral-sclerosis.original.pdf

HPV and ALS
http://health.usnews.com/health-news/blogs/on-women/2009/03/20/cdc-takes-closer-look-at-gardasil-and-paralysis

Gardasil contains the HPV of 16 and 18

since ALS has been linked to lung and testicular cancers we may be looking at a specific HPV

hpv 16 and 18 are involved with lung cancer
http://www.ncbi.nlm.nih.gov/pubmed/23317184

HPV 16 was found with testicular cancer
http://www.ncbi.nlm.nih.gov/pubmed/16119985

HPV could be using cannabinoid receptors. There are 2 types of cannabinoid receptors.  Type one is expressed by the central nervous system, lungs, liver and kidney.  Type 2 is expressed by the immune system.

The nerves that express the cannabinoid receptors
http://www.ncbi.nlm.nih.gov/pubmed/15927811

Both CB1and CB2 are expressed by skin nerve fibers.
http://www.ncbi.nlm.nih.gov/pubmed/15927811

CB1 receptor is expressed on testicular cells
http://www.ncbi.nlm.nih.gov/pubmed/16025865

So are we looking at HPV 16 and the CB1 receptors for ALS? if ALS is autoimmune then why no distinctive antibodies? the ones reported sound like guillain barre.

Trichophyton cencetricum and ALS...definitely connected but is autoimmune cross-targeting with herpes or is it from the aflatoxin like compound that is made that destroys the nerve?

Aflatoxin like compounds are made by some dermatophytes
http://www.ncbi.nlm.nih.gov/pubmed/1170494
specifically T.concetricum

Guam has high rates of ALS
https://gerontologist.oxfordjournals.org/content/early/2014/07/25/geront.gnu072.full.pdf

High rates of trichophyton concentricum on Solomon children (close to guam and makes you wonder if both areas share this infection)
https://www.researchgate.net/publication/281516255_Trichophyton_concentricum_in_skin_lesions_in_children_from_the_Salomon_Islands

ALS and lakes in new england
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922844/

Has this t.concentricum moved into these lakes?

Earlier posts looking at ALS , tyrosol, and the tau protein:
http://angelabiggs.blogspot.com/2016/03/microtubule-disease-issues-aflotoxin.html
http://angelabiggs.blogspot.com/2016/02/tyrosol-as-quorum-of-trichophyton.html

How does one distinguish ALS from guillain barre if they are both attacks on the nerves? is it the larger infection ?

Tad-43 and ALS
http://www.ncbi.nlm.nih.gov/pubmed/18989684

the relationship between tad-43 and Tau proteins is being analyzed
http://www.alzheimersanddementia.com/article/S1552-5260(13)01524-0/abstract
http://neurolink.athenadiagnostics.com/tdp-43-the-third-protein-linked-to-alzheimers-disease/

Previously I had looked at the relationship of aflatoxin and Tau since aflatoxin binds to microtubules and tau is a microtubule associated protein.  Does aflatoxin damage/change the DNA and cause the Tad-43?

Garlic and frontal lobe dementia
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074326/

Garlic compounds prevented the binding of aflatoxin to the DNA
http://www.tandfonline.com/doi/abs/10.1080/01635589109514116?journalCode=hnuc20

note that aspergillus grows on bulbs like onions and garlic....and i had previously believed this group had sensitivies/allergies to them (bulb plants) Do people with ALS have allergies?

Older post
http://angelabiggs.blogspot.com/2016/03/microtubule-disease-issues-aflotoxin.html

Furthermore: tyrosol from trichophyton could explain some of the vitiligo found in some ALS cases

Does Trichophyton make tyrosol as it's quorum??? I have no proof yet but this might explain vitiligo without addison's disease

Tyrosol inhibits tyrosinase (a step in melanogenesis)
http://www.ncbi.nlm.nih.gov/pubmed/24287915

Zika can infect myelin and could trigger multiple sclerosis

melanocortin and schwann cell development (the schwann cells which make the myelin sheath have the melanocortin 2 receptor)
http://www.ncbi.nlm.nih.gov/pubmed/7651907

Org2766 is an ACTH analog
http://www.ncbi.nlm.nih.gov/pubmed/8866933

If Zika uses the ACTH receptors (MCR2)  this would explain how the myelin sheath is involved
http://www.the-scientist.com/?articles.view/articleNo/45803/title/Zika-Linked-to-Another-Neurological-Disorder/

This also means that Zika could trigger multiple sclerosis like the herpes virus but only in those people with mycobacteria infecting the myelin.

see earlier blog posts like the Zika file
http://angelabiggs.blogspot.com/2016/05/the-zika-file.html

Multiple sclerosis and autoimmune cross-targeting on the myelin

Autoimmune cross-targeting hypothesis

The layering of 2 different infections on one target triggering autoimmune disease.  A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria infection marking the outside.

The cross-targeting is occurring on the myelin.
http://www.sciencedirect.com/science/article/pii/S0092867400811071

HHV6 (6th disease aka roseola)  and multiple sclerosis
http://www.ncbi.nlm.nih.gov/pubmed/12717617
http://www.ncbi.nlm.nih.gov/pubmed/12717618

My previous blog post looked at herpes zoster (HHV3) and mycobacterias or staph
http://angelabiggs.blogspot.com/2016/01/multiple-sclerosis-and-seizures.html

herpes zoster was found in brain stem multiple sclerosis
http://www.ncbi.nlm.nih.gov/pubmed/26907823 

note that the oligodendrocytes have been shown to have estrogen receptors specifically ERbeta which cycles to the mitochondria is found in the myelin of the CNS, spinal cord, and brain
http://www.ncbi.nlm.nih.gov/pubmed/14991836

I have been suggesting that herpes viruses use estrogen receptors to enter cells
http://angelabiggs.blogspot.com/2015/07/do-herpes-viruses-use-estrogen.html

mycobacteria and Epstein barr virus in multiple sclerosis
http://www.ncbi.nlm.nih.gov/pubmed/26956729
http://www.ncbi.nlm.nih.gov/pubmed/26453465

Psoriasis has been connected to MS
http://www.ncbi.nlm.nih.gov/pubmed/26352056
http://www.ncbi.nlm.nih.gov/pubmed/27125193
http://www.ncbi.nlm.nih.gov/pubmed/19924503

psoriasis mycobacteria
http://www.ncbi.nlm.nih.gov/pubmed/24050284
http://www.ncbi.nlm.nih.gov/pubmed/18485527

mycobacteria infect schwann cells which produce myelin
http://www.ncbi.nlm.nih.gov/pubmed/20739294
http://www.ncbi.nlm.nih.gov/pubmed/15019586

Note: schwann cells produce the myelin for the peripheral nerves while oligodendrocytes produce the myelin for the central nervous system....the same sort of cells 

Is Bell's palsy triggered by autoimmune cross-targeting? herpes simplex with a spirochete?

Autoimmune cross-targeting hypothesis

The layering of 2 different infections on one target triggering autoimmune disease.  A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria infection marking the outside.

bell's palsy and spirochetes
http://www.ncbi.nlm.nih.gov/pubmed/2589070bBorrelia
http://www.ncbi.nlm.nih.gov/pubmed/1632233 Borrelia
http://www.ncbi.nlm.nih.gov/pubmed/365078 Syphilis
http://www.ncbi.nlm.nih.gov/pubmed/12284236 syphilis
http://www.ncbi.nlm.nih.gov/pubmed/25648561 Leptospira
http://www.ncbi.nlm.nih.gov/pubmed/21613003 Leptospira
http://www.ncbi.nlm.nih.gov/pubmed/15287387 Leptospira


bell's palsy and herpes simplex not herpes....see below
http://www.ncbi.nlm.nih.gov/pubmed/9393551
http://www.ncbi.nlm.nih.gov/pubmed/16917546

is bell's palsy an autoimmune disease?
http://www.ncbi.nlm.nih.gov/pubmed/22684016 
http://www.ncbi.nlm.nih.gov/pubmed/22934210
http://www.ncbi.nlm.nih.gov/pubmed/51046  (compares it to guillian barre)

newer post examines HLAs and vaccine triggers: Flu viruses are more likely to be triggering Bell's palsy.

The Zika file

Autoimmune cross-targeting hypothesis

The layering of 2 different infections on one target triggering autoimmune disease.  A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria infection marking the outside.

Zika + campylobacteria/sutterella at the peripheral nerves = guillian barre
Zika + staph at the CNS = acute flaccid paralysis
Zika + strep at the brain = encephalitis
Zika + mycobacteria at the substantia nigra = parkinson's
Zika + spirochetes like H.pylori at the bone marrow = Idopathic thrombocytopenic purpura 

There are blog posts for these containing reference links.

Co-carcinogenesis 

Rous' hypothesis requires a virus and a carcinogen together to start cancer.  My co-carcinogenesis takes his further:  Carcinogens inhibit polymerases. (yes we have been told carcinogens cause DNA damage but I think their ability to inhibit polymerases causes most cancer. The cancers have patterns and are not that chaotic)

Alone a carcinogen would inhibit growth until a virus appears opens up the DNA and modifies the cell by binding telomeres, to create virus supplies forever.  The problem is the carcinogen inhibits the viral polymerase better than the human polymerase.  So instead of the virus making what it wants the infected cell is transformed into a cancer cell.

Zika + benzene at the  bone marrow = leukemia

Zika  + PCB at the prostate = prostate cancer???


Microcephaly and Zika

Flaviviruses could be using melanocortin receptors.  Zika must have chosen the MCR2 receptor as it's main receptor.  MCR2 is also the ACTH receptor. ACTH is the first hormone used by the babies brain to grow.

melatonin protecting against flavivirus infection through competition with the receptors?
http://www.ncbi.nlm.nih.gov/pubmed/14962057

Zika and melanocortin receptors
http://angelabiggs.blogspot.com/2016/01/does-zika-virus-use-melanocortin.html

ACTH receptors are on the placenta which is how this virus crosses better than the others and ACTH is the critical baby's brain growth hormone.

Calcium and ACTH
http://www.ncbi.nlm.nih.gov/pubmed/6284662
http://www.ncbi.nlm.nih.gov/pubmed/4323934

Pituitary cushing disease which has the characteristic of high ACTH from a tumor  has calcium deposits...which makes you wonder what the displaced ACTH is doing if the virus uses the ACTH receptor.  This could explain the calcium deposits in the brains of babies with Zika.

Can we use amantidine against Zika?

parkinson's drug works against west nile which is a flavivirus like Zika
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779909/

same drug works against the flu virus
http://www.ncbi.nlm.nih.gov/pubmed/20179772

Amantadine works on the flu viral matrix protein
http://www.ncbi.nlm.nih.gov/pubmed/759556

what is a viral matrix protein: links the outer viral coat to the RNA inside
https://en.wikipedia.org/wiki/Viral_matrix_protein

Just published May 3...a derivative of amatadine called mematine protects cells in petri dishes from zika!!!

http://www.usatoday.com/story/news/2016/05/02/researchers-look-repurpose-approved-drugs-treat-zika-virus/83815714/

of course the drugs were originally believed to be simple antagonists of the NMDA receptor
http://www.ncbi.nlm.nih.gov/pubmed/7884411

the function of them must be on the viral matrix protein of the viruses involved