Saturday, July 27, 2019

Bee allergy, t.gondii, and the cells cytosol : I am not sure what I am looking at.

cd16 is on Basophils of patients with insect venom allergy
https://www.ncbi.nlm.nih.gov/pubmed/30288810

IgG2 and insect venom allergy
https://link.springer.com/article/10.1007%2FBF00441707

malaria and IgG2
https://iai.asm.org/content/68/3/1252

t.cruzi and IgG2
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1577053/

malaria also infects the cytosol
https://science.sciencemag.org/content/328/5980/862/F2

old post about Bee allergy and T.gondii
https://angelabiggs.blogspot.com/2015/04/tgondii-and-bee-venom.html

T.gondii infects the cytosol. Previous hypothesis was that IgG2 is the antibody made against cytosol infections.  I was sorting the Fc receptors with the IgGsubsets...when this occurred to me.

These are not proven just appears to be a pattern
cd16 (fcgammaRIII) binds IgG3 which is high on platelets? mito/nucl viruses
cd16 (fcgammaRIV) binds IgG2b which is high on eosinophils? cytosol infection?
cd64 (fcgammaRI) binds IgG2a cytosol virus?
cd32 (fcgammaRII) binds IgG1 and is high on Langerhans?  outer antigens

Is this why the patients with insect allergy would have cd16?

T.gondii and Bee venom


Do people with bee sting allergies have t.gondii infections?

I have connected T.gondii with a variety of things: Seizures, Epilepsy, schizophrenia....but they are all  autoimmune which means cross-targeting autoimmunity must be occurring. A virus has to trigger the attack at the target tissue from the inside.  Are these autoimmune diseases all bee sensitive because of their connection to T.gondii?


Schizophrenia: t.gondii and the cytomegavirus
http://www.sciencedaily.com/releases/2013/03/130308111315.htm

Bee sting reactions have been found in schizophrenia patients
http://www.ncbi.nlm.nih.gov/pubmed/5239954

I have connected in the past seizures/epilepsy with t.gondii and enteroviruses 
http://angelabiggs.blogspot.com/2015/01/nodding-disease-epilepsy-seizuresare.html

Seizures and bee stings 
http://epilepsyfoundation.ning.com/group/support-for-cps/forum/topics/bee-stings-and-seizures?commentId=2217546%3AComment%3A908079&xg_source=activity&groupId=2217546%3AGroup%3A819391
http://www.ncbi.nlm.nih.gov/pubmed/22100477
http://www.japi.org/february_2012/11_cr_stroke_after_multiple.pdf

epilepsy and wasp stings
http://www.ncbi.nlm.nih.gov/pubmed/8844507
http://jnnp.bmj.com/content/74/1/134.2.full

Does Apis mellifera venom (honey bee venom) effect T.gondii?

I can't see this paper to find out: 
  • Effect of Bee Venom on Toxoplasma gondii Tachyzoites in vitro - Ahmad G. Hegazi, Hassan A. El-Fadaly and Ashraf M. BARAKAT (Egypt)

T.gondii is carried by mice and cats
T.cruzi is carried by kissing bugs and the dogs that eat them

T.cruzi which causes changas is killed by honey bee venom
http://www.ncbi.nlm.nih.gov/pubmed/23562368

The Kissing bug carries the T.cruzi the way mice carry T.gondii
http://blog.mysanantonio.com/animals/2013/09/san-antonio-humane-society-says-chagas-disease-possible-in-local-dogs/
note that kissing bugs are nocturnal so keep your pet in at night

Hymenoptera are the venom group of  Apoidea (bees), Vespoidea (wasps, hornets, and yellow jackets), and Formicidae (ants). 

What is it in the bee sting that Toxoplasmas dislike? perhaps the compound apamin which can cross the blood brain barrier. (our nerves don't like it either)
http://pubs.acs.org/doi/abs/10.1021/bi00682a035

Interestingly HoneyBee venom has been a remedy for malaria too.

Panafrican News Agency (PANA). 17 September 1997. Yahya el Hassan. "Curing Malaria with Bee Stings in Sudan." [Internet]. [Accessed 24 Dec. 1998].

https://books.google.com/books?id=JlSJDj5Lt98C&pg=PA153&lpg=PA153&dq=bee+stings+and+malaria&source=bl&ots=kXRWjUnlba&sig=Q7s5Av9JLOys_nMEi8I5pfzmRUg&hl=en&sa=X&ei=oeQlVZaHA8K1oQTxpoHACQ&ved=0CCkQ6AEwAg#v=onepage&q=bee%20stings%20and%20malaria&f=false

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