Saturday, July 13, 2019

IgG2, cytosol infections, and the lectin pathway.

Complement activation and Antibodies
https://www.ncbi.nlm.nih.gov/pubmed/20151159

Classical pathway: IgG1 and IgG3

Alternative and lectin: IgG2 and IgG4

LPS triggers the TLR4 or the lectin-mannose complement activation.  These tend to be the type of infections that can move inside of cells.  Some infections move into the vacuoles and organelles others the cytosol.

Strep has even been shown to move inside of cells allowing the bacteria to survive antibiotics. https://www.ncbi.nlm.nih.gov/books/NBK333420/

basophils as APC to TH2 inducing il-13
https://onlinelibrary.wiley.com/doi/pdf/10.1002/eji.201040588














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