Hypothesis: GSDM pores are windows for eosinophils
Does the GSDM pore hold the infection inside of cells at the surface and allow eosinphils to phagocytosis infected cells through antibody binding at the pore?
il-13 and IgG2 production by B cells
https://www.ncbi.nlm.nih.gov/pubmed/10415009
High IgG2 and Cryptococcus neoformans
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828574/
Cryptococcus neoformans inside macrophages
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127716/
il-13 and C. neoformans
https://www.ncbi.nlm.nih.gov/pubmed/17911623
Does the GSDM pore hold the infection inside of cells at the surface and allow eosinphils to phagocytosis infected cells through antibody binding at the pore?
IgE at the skin's IGF-1 with the GSDMA pore
IgA , GH with GSDMB
IgG1, insulin with GSDMC
IgG2 with GSDMD...all areas involving cytosol infections
High IgG2 and Plasmodium
https://iai.asm.org/content/iai/68/3/1252.full.pdf
Plasmodium are inside erythrocytes
https://academic.oup.com/femsre/article/40/5/701/2198099
eosinophils and plasmodium (malaria parasite)
mycobacteria and cytosol
https://academic.oup.com/femsre/article/43/4/341/5420823
mycobacteria and IgG2
https://gh.bmj.com/content/4/Suppl_3/A31.2
mycobacteria and GSDMD
https://www.biorxiv.org/content/biorxiv/early/2019/02/17/514125.full.pdf
Does the GSDM pore hold the infection inside of cells at the surface and allow eosinphils to phagocytosis infected cells through antibody binding at the pore?
il-13 and IgG2 production by B cells
https://www.ncbi.nlm.nih.gov/pubmed/10415009
High IgG2 and Cryptococcus neoformans
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828574/
Cryptococcus neoformans inside macrophages
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127716/
il-13 and C. neoformans
https://www.ncbi.nlm.nih.gov/pubmed/17911623
Does the GSDM pore hold the infection inside of cells at the surface and allow eosinphils to phagocytosis infected cells through antibody binding at the pore?
IgE at the skin's IGF-1 with the GSDMA pore
IgA , GH with GSDMB
IgG1, insulin with GSDMC
IgG2 with GSDMD...all areas involving cytosol infections
High IgG2 and Plasmodium
https://iai.asm.org/content/iai/68/3/1252.full.pdf
Plasmodium are inside erythrocytes
https://academic.oup.com/femsre/article/40/5/701/2198099
eosinophils and plasmodium (malaria parasite)
mycobacteria and cytosol
https://academic.oup.com/femsre/article/43/4/341/5420823
mycobacteria and IgG2
https://gh.bmj.com/content/4/Suppl_3/A31.2
mycobacteria and GSDMD
https://www.biorxiv.org/content/biorxiv/early/2019/02/17/514125.full.pdf
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