At the intestine: inner antigens are processed at ILFs while outer antigens are processed in Peyer patches.
ILF: inducible lymph follicle
https://www.ncbi.nlm.nih.gov/pubmed/12759424
"In contrast to the spleen, LNs and PPs, ILFs are inducible structures developed after birth due to the presence of external stimuli43"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015111/
The MRC marginal reticular cells develop here at the inducible ILF of the intestine.
pericytes in the gut
https://www.ncbi.nlm.nih.gov/pubmed/30937864
Peyer patches have the FRC fibroblast reticular cells.
Brain macrophages : pericytes
https://www.ncbi.nlm.nih.gov/pubmed/10611494
MHC2 expression by pericytes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844098/
pericytes and the BBB
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292164/
peyer patch lacking mice had no IgA only IgG from ILFs
https://www.jimmunol.org/content/jimmunol/173/2/762.full.pdf
Remember the lymph structure and the separate zones for inner and outer antigens:
Then the spleen's separate zones:
Now looking for the MRC and the FRC we find very separate zones in the intestine:
ILF: inducible lymph follicle
https://www.ncbi.nlm.nih.gov/pubmed/12759424
"In contrast to the spleen, LNs and PPs, ILFs are inducible structures developed after birth due to the presence of external stimuli43"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015111/
The MRC marginal reticular cells develop here at the inducible ILF of the intestine.
pericytes in the gut
https://www.ncbi.nlm.nih.gov/pubmed/30937864
Peyer patches have the FRC fibroblast reticular cells.
Brain macrophages : pericytes
https://www.ncbi.nlm.nih.gov/pubmed/10611494
MHC2 expression by pericytes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844098/
pericytes and the BBB
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292164/
peyer patch lacking mice had no IgA only IgG from ILFs
https://www.jimmunol.org/content/jimmunol/173/2/762.full.pdf
Remember the lymph structure and the separate zones for inner and outer antigens:
Then the spleen's separate zones:
Now looking for the MRC and the FRC we find very separate zones in the intestine:
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