Correction on Cytokines and B cells becoming plasma cells and producing antibodies

I had il-4 as always with il-21 inducing B Cells but that didn't make sense because the B cell needed to know who it's T cell parter in order to make the correct antibody. Further the production of  IgG4 with a partner switch supports the Autoimmune Cross-targeting Hypothesis.

Possible? Are the cytokines matched up correctly?

Note that insulin creates IgG1, growth hormone creates IgA dimer, and IGF-1 creates IgE. 

Does that mean that the IgG4 goes against the hormone in control first? anti-insulin, anti-GH, anti-IGF-1?  unless it is a vacuole bacteria or fungal? Then it is IgG4 to neutrophils ? "ANCA" ?

Autoimmune Cross-targeting: Two infections on one tissue triggering the immune system. One inside while one is outside the tissue's cells 

http://angelabiggs.blogspot.com/2018/05/combined-autoimmune-cross-targeting.html