TSLP from epithelial and keratinocytes warn of bacteria

Epithelial and keratinocytes produce TSLP when infected.

TSLP stimulates langerhans cells and dendritic cells.
There are two isoforms of TSLP: a long and a short

The long form which appears with atopic dermatitis  (staph) simulates the myeloid dendritic cell to produce il-23 while the short form which appears with celiac disease (e.coli) stimulates Langerhans dendritic cells.

TSLP Thymic stromal lymphopoietin stimulates TH1 and Th17
https://ard.bmj.com/content/70/Suppl_2/A43.3

TSLP and il-13 Th2 cells
https://www.jacionline.org/article/S0091-6749(07)03504-X/fulltext

il-13 appears with bacterial infections that move inside of host cells.  Visible bacteria or parasites that stay outside of host cells trigger il-4 pathways

atopic dermatitis, TSLP, and il-13
https://www.jacionline.org/article/S0091-6749(07)03504-X/fulltext

staph triggers TLR2 producing TSLP
https://www.ncbi.nlm.nih.gov/pubmed/21050945

staph moves into skin cells and hide in vacuoles
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417557/

TSLP activates myeloid dendritic cells which are responsible for triggering TH1 cytosol infection pathways
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645262/

Th17 cells pop inner organelles

GM-csf is also involved with vacuole bacteria. GM-csf is secreted by macrophages, T cells, Nk cells, and mast cells.

GM-csf is stem cell stimulating: basophils, esoinophils, and neutrophils

GM-csf exposed Basophil's produce il-6 and trigger th17
https://www.nature.com/articles/srep41744

GM-csf exposed mDendritic make il-23
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297527/