Natural killer follicular helper cells and gamma delta T cells appear to be working together against lipid antigens.
NKT cells have the "lipid TCR" with type one invariant binding the common parasite lipids and type 2 generating diverse foreign lipid binding.
NKT Follicular helper and CD1 dependent expansion
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406267/
cd1d on myeloid dendritic
http://www.jimmunol.org/content/165/7/3756
cd4 clip is on nk
https://www.ncbi.nlm.nih.gov/pubmed/16951326
NKT cells have the "lipid TCR" with type one invariant binding the common parasite lipids and type 2 generating diverse foreign lipid binding.
NKT Follicular helper and CD1 dependent expansion
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406267/
cd1d on myeloid dendritic
http://www.jimmunol.org/content/165/7/3756
cd4 clip is on nk
https://www.ncbi.nlm.nih.gov/pubmed/16951326
Pondering....this diagram could be incorrect but it looks like it could be generating delta gamma antibodies.
compare with'
Previous blog post on gamma delta t cells
gamma dela t cells can stimulate cd4 Th1 cells and appear to use icosl
icos and iNKT
gamma delta T cells forming germinal centers like B cells
somatic hypermutation of gamma delta cells in camels
NKT cells directly attack infections as well.
The secretion of gm-csf by NKT inhibits bacterial growth
Seems as if when the lipids are not presented but encountered directly the NKT cells act more like NK cells.
NK vs NKT
Note that NK cells have KIR which is the TCR for the HLA mailboxes for non DNA containing organelles : endosome, exosome, golgi, and ER. When the ER and golgi are infected proteins often do not even make it to the cell surface which means these NK cells are also responsible for killing naked cells.
NK also aides in killing other infections
nkp44 (nuclear/mito) nkp24 (cytosol), and nkp30 (bacterial or fungal)
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