Monday, August 27, 2018

Contemplating NK cells



I am currently looking at the non classical mhc-1b with the increased NK ly49 with listeria vacuole infected mice.  The NK with il-23 may do more than secrete il-22.

HLA are Mailboxes for T cells or NK.  Here are the NK mailboxes: HLA- E, F, G and C
Note that KIRs don't just trigger NK for naked cells but these specific mailboxes.

HLA-E and cd94 (nkg2a)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20238/

seen with salmonella infections of the golgi

HLA-F and KIR receptors (kir2ds4  kir3dl2)
https://www.ncbi.nlm.nih.gov/pubmed/24018270

seen with japanese encephalitis virus infection of the lysosome

HLA-G and kir2dl4
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422731/

seen with pseudomonas aeruginosa infections of exosomes

HLA-c and NK
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088962/

infections of the ER
https://jvi.asm.org/content/91/15/e00499-17.full

HLA-c and KIR
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211839/

HLA-C, KIR, and Hep C
https://www.ncbi.nlm.nih.gov/pubmed/16571411



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