il-21 and CD8 cells
il-21 increases the cytotoxicity of CD8 cells
il-21 review
https://www.ncbi.nlm.nih.gov/pubmed/17953510?sso-checked=true&dopt=Abstract
il-21 triggers the Th17 cells
http://www.bloodjournal.org/content/120/19/3925?sso-checked=true
Th17 are needed to pop the nuclear and mitochondrial membranes.
Hypothesis: both il-21 and TGF-B1 trigger the popping of these membranes.
http://angelabiggs.blogspot.com/2018/01/th17-cells-second-popping-cytokines-il.html
the il-21 is needed from cd4 cells for the cd8 cells to fight nuclear viruses
http://jvi.asm.org/content/85/2/733.abstract
TLR7/9 triggering releases either TGF-b1 or IFNalpha
TGF-b1 causes a burst of TGF-b1 from platelets
The dendritic cells or macrophages where the "MET"hands allowing them to digest virally infected cells and present to CD8 cells
The CD8 cells that are antigen exposed either move to the B zone to become follicular helper like and create with the B cells IgG3 or they become CTL cells.
The IFN alpha primes the cd8 cells
https://www.ncbi.nlm.nih.gov/pubmed/22925929
CD4 cells secrete il-21
http://jvi.asm.org/content/85/2/733.abstract (repeat)
The il-21 differentiates the CTL
https://www.ncbi.nlm.nih.gov/pubmed/23479229
Note that this type of il-21 CTL uses the MHC1 mailbox while the il-2 CTL uses FASL.
il-2 produced by TH1 cells during a cytosolic infection and MHC2 mailboxes are used.
il-21 increases the cytotoxicity of CD8 cells
il-21 review
https://www.ncbi.nlm.nih.gov/pubmed/17953510?sso-checked=true&dopt=Abstract
il-21 triggers the Th17 cells
http://www.bloodjournal.org/content/120/19/3925?sso-checked=true
Th17 are needed to pop the nuclear and mitochondrial membranes.
Hypothesis: both il-21 and TGF-B1 trigger the popping of these membranes.
http://angelabiggs.blogspot.com/2018/01/th17-cells-second-popping-cytokines-il.html
the il-21 is needed from cd4 cells for the cd8 cells to fight nuclear viruses
http://jvi.asm.org/content/85/2/733.abstract
TLR7/9 triggering releases either TGF-b1 or IFNalpha
TGF-b1 causes a burst of TGF-b1 from platelets
The dendritic cells or macrophages where the "MET"hands allowing them to digest virally infected cells and present to CD8 cells
The CD8 cells that are antigen exposed either move to the B zone to become follicular helper like and create with the B cells IgG3 or they become CTL cells.
The IFN alpha primes the cd8 cells
https://www.ncbi.nlm.nih.gov/pubmed/22925929
CD4 cells secrete il-21
http://jvi.asm.org/content/85/2/733.abstract (repeat)
The il-21 differentiates the CTL
https://www.ncbi.nlm.nih.gov/pubmed/23479229
Note that this type of il-21 CTL uses the MHC1 mailbox while the il-2 CTL uses FASL.
il-2 produced by TH1 cells during a cytosolic infection and MHC2 mailboxes are used.
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