anterior cingulate cortex, hoarding, cortisol, spirochetes, cataracts, and depression

This post is analyzing the areas of overlap of cortisol.  It is unclear how spirochetes cause the high cortisol involved.

Recently it was made clear that OCD is not the same as emotional hoarding. If we remove the OCD and look just at the type of hoarding where the patient has the inability to give up an object no matter how illogical..this could be a distinct disorder with a distinct infection.

Area of the brain changed in a hoarder
http://www.medicalnewstoday.com/articles/248862.php
http://blogs.scientificamerican.com/observations/scans-of-hoarders-brains-reveal-why-they-never-de-clutter/

This area of the brain is responsible for the cortisol awakening response.

Serotonin 4 receptor and the cortisol awakening response
http://www.ncbi.nlm.nih.gov/pubmed/26894483

Morning awakening and the burst of cortisol
http://www.ncbi.nlm.nih.gov/pubmed/20026350

cortisol awakening and depression
http://www.ncbi.nlm.nih.gov/pubmed/25999722

High rates of panic attacks with Hoarding
http://www.ncbi.nlm.nih.gov/pubmed/24854164

Panic attacks and cortisol
http://www.ncbi.nlm.nih.gov/pubmed/10698825

Anxiety disorder and cortisol
http://www.ncbi.nlm.nih.gov/pubmed/26934635

High rates of depression and anxiety with hoarding.
http://www.ncbi.nlm.nih.gov/pubmed/25732668
http://www.ncbi.nlm.nih.gov/pubmed/23505992

high rates of depression with borrelia burgdorferi infection
https://www.ncbi.nlm.nih.gov/pubmed/12194228

So I am going to start with a "reach" looking at spirochete infections as the possible cause of high cortisol concentrations and see how many areas of overlap I can find.

ten most depressed states: more spirochetes?
http://www.health.com/health/gallery/0,,20483493,00.html/view-all

Could spirochetes cause this? There are 2 spirochetes I am going to focus on : the Borrelia which is carried by ticks and then Leptospira which is carried by dogs.

spirochete review paper
http://www1.biogema.de/WEK/312-Margulis-final.pdf

The quorum, which is the chemical communication of an infection, can interfere with the host's body. What is the quorum of spirochetes and can it explain the cortisol issue.

Borrelia's quorum: Lux...does epinephrine exist too?
http://www.ncbi.nlm.nih.gov/pubmed/12941391
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC128172/

Borrelia's quorum: c-di-GMP 
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1002133
this is not made very long but in the transition
 c-di-GMP appears to govern a catabolic switch in B. burgdorferi and plays a vital role in the tick part of the spirochetal enzootic cycle. It is not need to infect mammals but just ticks

e.coli and salmonella use both lux and epinephrine as quorums..are spirochetes similar?
do spirochetes use epinephrine? or because we see such high levels of cortisol are they making or stimulating that? Can infections make cortisone?

http://www.nytimes.com/1995/02/15/us/personal-health-when-lyme-invades-the-brain-and-spinal-system.html

Borreliosis in children
http://www.ncbi.nlm.nih.gov/pubmed/13130169

adults with borreliosis
http://www.ncbi.nlm.nih.gov/pubmed/12225315

 facial palsy with both

acute mycocarditis and borreliosis
http://www.ncbi.nlm.nih.gov/pubmed/1535149
http://www.ncbi.nlm.nih.gov/pubmed/15810500
http://www.ncbi.nlm.nih.gov/pubmed/7726189

increased hair cortisol before acute mycocarditis
http://www.ncbi.nlm.nih.gov/pubmed/20812871

lyme and the mind
http://www.mentalhealthandillness.com/Articles/LymeDiseaseAndCognitiveImpairments.htm

Lyme and depression...the serotonin receptors...not depressed rather emotionally dumb
http://www.examiner.com/article/the-difference-between-depression-and-lyme-depression

phobias, anxiety and cortisol
http://www.webmd.com/anxiety-panic/news/20110328/cortisol-may-help-reduce-some-phobias

cortisol and the brain
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795004/

This doctor claims depression medicine causes cataracts but what if cortisone caused both the depression and the cataracts
http://www.secondopinionnewsletter.com/Health-Alert-Archive/View-Archive/1729/The-overlooked-link-between-depression-and-cataracts.htm

Lyme and cataracts
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049946/

Leptospira is a spirochete carried by dogs which can be caught by people.

cortisone causes cleft palate
http://dev.biologists.org/content/develop/5/2/201.full.pdf

Leptospira and clotting
http://www.ncbi.nlm.nih.gov/m/pubmed/20002620/

Do the bacteria secrete something that induces cortisol or do they secrete cortisol themselves?  how does cushing syndrome fit in here?

Looking at other endotoxin bacterias they have noticed that salmonella seems to have a relationship with cortisol. They proliferate with cortisol and levels tend to go up during infection.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256119/

Acute disseminated encephalomyelitis autoimmune cross-targeting of strep and a virus like zika?

Acute disseminated encephalomyelitis is an autoimmune inflammatory disease of the brain and spinal cord.

Autoimmune Cross-targeting hypothesis:  2 simultaneous infections on one target triggers autoimmunity.  One infection is on the outside of the target cell and one infection is on the inside of the target. The partners of the infection can vary but the inside and outside paradigm is what triggers the autoimmune response that results in the development of autoimmune disease.

zika and acute disseminated encephalomyelitis
http://www.telegraph.co.uk/news/2016/04/10/now-scientists-find-zika-linked-brain-disorder-in-adults/
http://www.aol.com/article/2016/04/10/scientists-find-new-zika-linked-brain-disorder-in-adults/21341521/

The question is: do these patients have strep infections or have they just recovered from strep infections?

Other flaviviruses behave similarly.

dengue and acute disseminated encephalomyelitis
http://www.ncbi.nlm.nih.gov/pubmed/24250170
http://www.ncbi.nlm.nih.gov/pubmed/12111572
http://www.ncbi.nlm.nih.gov/pubmed/17568897

west nile, meningitis/ acute disseminated encephalomyelitis
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747452/ (and strep)
http://www.ncbi.nlm.nih.gov/pubmed/21612601
http://www.ncbi.nlm.nih.gov/pubmed/16447753
http://www.ncbi.nlm.nih.gov/pubmed/15647737

strep and acute disseminated encephalomyelitis
http://www.ncbi.nlm.nih.gov/pubmed/11706964
http://www.ncbi.nlm.nih.gov/pubmed/11891098
http://www.ncbi.nlm.nih.gov/pubmed/10751252
http://pandasnetwork.org/SwedoSnider2003.pdf

pandas following acute disseminated encephalomyelitis
http://pandasnetwork.org/first-case-report-of-pans-published-in-pediatrics/
http://www.ncbi.nlm.nih.gov/pubmed/23142103


Summary of Zika virus complictions

Zika and campylobacteria at peripheral nerves could cause Guillian Barre
Zika and strep at the spinal cord and brain could cause acute disseminated encephalomyelitis/pandas
Zika and mycobacteria at substantia nigra could cause a form of parkinson's disease
Zika and Benzene in the bone marrow could cause leukemia.

Seems logical that this Zika viruse could cross-target with strep and trigger the acute disseminated encephalomyelitis with pandas syndrome following.

Only with Zika if it is using the ACTH (Melanocortin2 receptors) the inflammation area might be greater than the other melanocortin receptor using flaviviruses.

Further if we look at these other diseases we find that a parkinson's disease drug has been found to be active against flaviviruses and could be useful against zika.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779909/

what does Aflatoxin do ? the mitochondria of cells has a strong relationship with the cytoskeleton

There are morphological cell shape changes due to microfilament changes and a loss of F-actin with aflatoxin exposure
http://www.ncbi.nlm.nih.gov/pubmed/3111878

aflatoxin poisoning and liver
http://www.ncbi.nlm.nih.gov/pubmed/3111878

ALS and abnormal livers..with bizarre giant mitochondria
http://www.ncbi.nlm.nih.gov/pubmed/3800708

aspergillus infections or trichophyton, pick's disease, ALS, and Asperger's
http://angelabiggs.blogspot.com/2016/03/microtubule-disease-issues-aflotoxin.html

the cytoskeleton and mitochondria
http://www.sciencedirect.com/science/article/pii/S0005272806001101

Tau is a microtubule associated protein
http://www.ncbi.nlm.nih.gov/pubmed/27030133

Tau proteins cover MT during polymerization
http://www.ncbi.nlm.nih.gov/pubmed/26996940

Looks like aflatoxin blocks polymerization ??? which then causes tau to precipitate ?

Non-hodgkin's lymphomas and co-carcinogenesis

Francis Peyton Rous' Co-carcinogenesis hypothesis: that a virus and a carcinogen together cause cancer. (1966 Nobel prize for HPV work)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135410/

My co-carcinogenesis takes his further because carcinogens inhibit polymerases.

What I surmise from his hypothesis:

Cancer occurs because a carcinogen inhibits the viral polymerase better than the human polymerase. When a virus infects the same cell's nucleus as a carcinogen they interact.  Instead of the virus making what it wants in the host the infected cell is transformed into a cancer cell by the carcinogen. 

Non-Hodgkin's Lymphoma carcinogens

Naphthalene
http://epub.uni-regensburg.de/29760/1/journal.pone.0092787.pdf
http://onlinelibrary.wiley.com/store/10.1002/3527600418.mb9120e0011/asset/mb9120e0011.pdf?v=1&t=imv0o9nh&s=36f6894effd0fb56bec5bd1ccdb4d9f1329d3d1c

black tattoo and lymph nodes: Carbon Black or polycyclic aromatic hydrocarbons (PAH).
http://epub.uni-regensburg.de/29760/1/journal.pone.0092787.pdf

Napthalene is a PAH (joined benzene rings)
http://www.env.gov.bc.ca/wat/wq/BCguidelines/pahs/pahs-01.htm

mothballs and non-hodgkin's lymphoma
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1247554/

Parasites that feed on red blood cells like malaria release free heme into the blood which the parasites convert to Hemozion (brown malaria pigment) Could this process possibly produce a carcinogen ? Explaining the patterns in Africa? Does the parasite's enzyme that binds heme also bind polymerases? The known carcinogen benzene binds both heme and polymerases...just a thought.


Diffuse large B cell lymphomas (most common)

 Hepatitis C and EBV...still researching this one

EBV and diffuse (slow type?)
https://www.ncbi.nlm.nih.gov/pubmed/26258272
https://www.ncbi.nlm.nih.gov/pubmed/25475080

Hep C and Diffuse (fast?)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145748/


Follicular lymphoma and polyomaviruses

merkel cell polyomavirus and follicular lymphoma
https://www.ncbi.nlm.nih.gov/pubmed/21414663

 simian virus 40  and non-hodgkin's
http://www.ncbi.nlm.nih.gov/pubmed/25877010
http://www.ncbi.nlm.nih.gov/pubmed/15367569
http://www.ncbi.nlm.nih.gov/pubmed/15941954

JC and BK polyomaviruses
http://www.ncbi.nlm.nih.gov/pubmed/16537714
http://www.ncbi.nlm.nih.gov/pubmed/15941954

Hepatitis B
http://www.ncbi.nlm.nih.gov/pubmed/26885191
http://www.ncbi.nlm.nih.gov/pubmed/23562041

note that non-hodgkin's typically starts at the lymph nodes not at the bone marrow and still could be caused by epstein barr infecting with the estrogen receptors
http://www.ncbi.nlm.nih.gov/pubmed/22247563

Burkitt Lymphoma

Two types of Burkitt : endemic (africa & brazil) and sporatic (western countries with AIDS)
https://www.researchgate.net/publication/307157262_Differential_IgM_expression_distinguishes_two_types_of_pediatric_Burkitt_lymphoma_in_mouse_and_human

Does only EBV cause Burkitt or can HIV cause it too?

HIV and herv-k
http://journals.lww.com/jaids/Fulltext/2011/04002/183_HIV_Exposes_Major__Trafficking__in_HERV__K.76.aspx

Note that EBV was first isolated in 1964 from a Burkitt tumor of an african patient

Burkitt lymphoma and epstein barr

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2269718/

Burkitt lymphoma and hypermethylation

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571983/

 Primary effusion lymphoma

HHV8 and Primary effusion
http://www.bloodjournal.org/content/122/23/3712?sso-checked=true

Benzene, bone marrow, and co-carcinogenesis: a carcinogen and a virus synergistically causing cancer (Zika's flavivirus family is involved)

Co-carcinogenesis : Rous' hypothesis requires a virus and a carcinogen together to start cancer.

My co-carcinogenesis takes his further:  Carcinogens inhibit polymerases.

(yes we have been told carcinogens cause DNA damage but I think their ability to inhibit polymerases causes most cancer. The cancers have patterns and are not that chaotic)

Alone a carcinogen would inhibit growth until a virus appears opens up the DNA and modifies the cell to create virus supplies for ever.  The problem is the carcinogen inhibits the viral polymerase better than the human polymerase.  So instead of the virus making what it wants the infected cell is transformed into a cancer cell.

Different carcinogens are absorbed by different areas of the body. Benzene saturates and waits in the bone marrow.

With all the fracking contaminating well water with benezene...the public should be aware of the risks.

benzene and leukemia
http://www.ncbi.nlm.nih.gov/pubmed/9118924
http://www.ncbi.nlm.nih.gov/pubmed/27049659
http://www.ncbi.nlm.nih.gov/pubmed/9155776
http://www.ncbi.nlm.nih.gov/pubmed/9118924

childhood leukemia and benzene
http://www.medscape.com/viewarticle/857205
http://www.ncbi.nlm.nih.gov/pubmed/27043530
http://www.ncbi.nlm.nih.gov/pubmed/26589707
http://www.ncbi.nlm.nih.gov/pubmed/25333868

anemia and benzene (alone it inhibits growth)
http://www.ncbi.nlm.nih.gov/pubmed/8987251
how benzene causes this is unknown

benzene inhibits polymerases
http://www.ncbi.nlm.nih.gov/pubmed/3381009
http://www.ncbi.nlm.nih.gov/pubmed/2926830
http://www.ncbi.nlm.nih.gov/pubmed/4006011 (mito but still a polymerase....needs to happen in the nucleus to cause cancer)

Leukemia and benzene from highway
http://timesofindia.indiatimes.com/life-style/health-fitness/health-news/Living-near-highway-may-increase-leukemia-risk-in-kids/articleshow/49009660.cms

Soda/drinks with too much benzene: is this still an issue?
http://www.cbsnews.com/news/fda-too-much-benzene-in-some-drinks/

FDA and benzene testing in sodas (vit C involved.. stick to OJ or other natural sources)
http://www.fda.gov/Food/FoodborneIllnessContaminants/ChemicalContaminants/ucm055131.htm

Fracking water and benzene...a thousand times what the FDA considers safe
http://www.latimes.com/local/california/la-me-fracking-20150211-story.html

link to other carcinogens and polymerases

http://angelabiggs.blogspot.com/2015/11/carcinogens-inhibit-polymerases.html

The viruses that infect bone marrow where the benzene is known to go:

Flaviviruses seem linked to leukemia

Flaviviruses and bone marrow
http://www.ncbi.nlm.nih.gov/pubmed/7663049
Hepatitis C (flavivirus)
http://www.ncbi.nlm.nih.gov/pubmed/20095034
http://www.ncbi.nlm.nih.gov/pubmed/8037177
Dengue and leukemia
http://www.ncbi.nlm.nih.gov/pubmed/24793316
west nile and leukemia
http://www.ncbi.nlm.nih.gov/pubmed/16344671
http://journals.lww.com/jpho-online/Abstract/2005/12000/West_Nile_Virus_Infection_in_a_Teenage_Boy_With.6.aspx
http://wwwnc.cdc.gov/eid/article/7/4/01-7432_article ?
http://www.auntminnie.com/index.aspx?sec=ser&sub=def&pag=dis&ItemID=56900?

Zika fatalities :

"The patients who died were a 2-year-old girl, a 30-year-old woman, a 61-year-old man, and a 72-year-old woman. The two older patients had underlying medical conditions that were well-controlled with medications. After death, the two younger ones were found to likely have had acute leukemia."
http://www.cidrap.umn.edu/news-perspective/2016/04/report-outlines-patterns-rare-fatal-zika-infections

Would the viral encephalitis of Zika patients would look like other flaviviral infections. (brain image D)? or because the virus uses ACTH receptors is it wide spread???

http://www.neurology.org/content/70/1/84.full.pdf 

Herpes viruses seem to be linked to Hodgkin lymphoma

Epstein barr and lymphoma
http://www.sciencedirect.com/science/article/pii/S0093775414003017
http://www.ncbi.nlm.nih.gov/pubmed/25400806
http://www.ncbi.nlm.nih.gov/pubmed/24228130

CMV and bone marrow
http://www.ncbi.nlm.nih.gov/pubmed/9052914

there are community clusters of leukemia and lymphoma suggesting a similar cause (like benzene)
http://aje.oxfordjournals.org/content/162/9/817.long 

The leukemia clusters:
http://www.ncbi.nlm.nih.gov/pubmed/21352818

note that non-hodgkin's typically starts at the lymph nodes not at the bone marrow and still could be caused by epstein barr infecting with the estrogen receptors but the carcinogen is different.

mothballs and non-hodgkin's lymphoma
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1247554/

Is naphthalene the carcinogen that goes the lymph glands?

Tau protein, intestinal Ganglioneuromatosis and trichophyton concentricum?

Intestinal ganglioneurmatosis (damaged nerves and the presence of TAU protein)
https://www.researchgate.net/publication/10837617_Intestinal_ganglioneuromatosis_diagnosed_in_adult_patients

diffuse intestinal ganglioneurmatosis mimicking crohn's
http://www.ajronline.org/doi/full/10.2214/ajr.182.5.1821166

Patient with intestinal ganglioneurmatosis and cafe-au-lait spots with neurofibroma
https://www.researchgate.net/publication/230652593_Diffuse_intestinal_ganglioneuromatosis_of_the_ileum

neurofibroma can cause the cafe-au-lait spots
http://chealth.canoe.com/condition/getcondition/Neurofibromatosis

Does a non genetic form of neurofibroma exist and get misdiagnosed as crohn's?

I had previously looked at trichophyton violaceum. Trichophyton's quorum is tyrosol.

http://angelabiggs.blogspot.com/2016/02/tyrosol-as-quorum-of-trichophyton.html

Is the loss of the pigment from the quorum?

tinea imbrica´ta is the skin infection of trichophyton concentricum
https://en.wikipedia.org/wiki/Tinea_imbricata

Cafe-au-lait spots with tichophyton caninum (on dogs?)
https://books.google.com/books?id=XuA9AAAAYAAJ&pg=PA91&lpg=PA91&dq=cafe-au-Lait+trichophyton&source=bl&ots=WAZT2Ygbub&sig=zloXtJVKy-xRU3WO-1HhgiGmU7Q&hl=en&sa=X&ved=0ahUKEwjhyc3g98fLAhVR7GMKHUQVDDUQ6AEIRTAG#v=onepage&q=cafe-au-Lait%20trichophyton&f=false

could some neurofibromas be from aflatoxin and a virus?

The story behind aflatoxin's discovery:
https://books.google.com/books?id=Hnei-aspWQgC&pg=PA379&lpg=PA379&dq=neurofibroma+aflatoxin&source=bl&ots=1JSdorEHpd&sig=0EvUZpUMWxAaen2F0ZtWaKQR2Z4&hl=en&sa=X&ved=0ahUKEwisiMGp-8fLAhVJ6GMKHV-9DysQ6AEIMDAE#v=onepage&q=neurofibroma%20aflatoxin&f=false

IBS and lymphoma with EBV????
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277199/

Aflatoxin with EBV causing lymphoma
http://www.ncbi.nlm.nih.gov/pubmed/26424750

does aflatoxin inhibit polymerases like the other carcinogens?

aflatoxin inhibits polymerase indirectly by binding chromatin
http://www.ncbi.nlm.nih.gov/pubmed/3128406
http://www.ncbi.nlm.nih.gov/pubmed/2419004

Drug reaction with Eosinophila systemic syndrome and uric acid

Strong and sometimes fatal reactions to drugs involving Eosinophils appear to be caused by a state of high Uric acid.  This condition can result through infections releasing lactic acid which inhibits the secretion of uric acid or from viral infections damaging the kidneys which causes then a build up of uric acid.  It is this state of high uric acid that stimulates T helper 2 cells to increase Eosinophils.  Normally damaged tissues release uric acid as a signal to T helper 2 cells who then promote the Eosinophils but....when uric acid is artificially high...Eosinphils are out of control.


DRESS
Drug reaction with Eosinophila systemic syndrome
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718748/

Staph and DRESS
http://www.ncbi.nlm.nih.gov/pubmed/17053739

Clindamycin induced DRESS during staph infection
http://www.ncbi.nlm.nih.gov/pubmed/23165860

note that Allopurinol is a treatment for gout
Gout I connected to Staph
http://angelabiggs.blogspot.com/2016/03/staph-uric-acid-and-gout.html
allopurinol is one of the drugs triggering DRESS

ziprasidone: schizophrenia drug (t.gondii)
Dapsone: leprosy/mycobacteria or t.gondii infection
Allopurinol: gout drug (staph ? or t.gondii?)
sulfonamide : antibiotic
minocycline: mycobacteria and MARSA (staph)
lamotrigine: seizure and schizophrenia drug
phenytoin: seizure medication

Do these drugs cause a reaction from infections? Do these drugs stimulate the infections to make lactic acid?

Is the uric acid from high lactic acid ? staph makes lactic acid and so does t.gondii
Lactic acid prevents the secretion of uric acid

t.gondii makes lactic acid
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1000188

schizophrenia and high uric acid levels
http://www.ncbi.nlm.nih.gov/pubmed/22926590

uric acid and chronic kidney disease
http://www.ncbi.nlm.nih.gov/pubmed/20683957
http://www.ncbi.nlm.nih.gov/pubmed/23543594

hyperurcemia is high blood uric acid

kidneys are suppose to secrete uric acid into urine

Eosinophils and the response to uric acid produced by damaged tissues (it's their job)
http://www.ncbi.nlm.nih.gov/pubmed/20483787

the high uric acid could be what triggers eosinophils (through T helper 2?)

What about the viral causes of DRESS? A virus doesn't make lactic acid.

HHV6 or epstein barr?  Do they damage the kidney's mitochondrias and cause a similar syndrome by elevating uric acid?  Is the condition to be feared high Uric acid?

Dysphagia,which is difficulty swallowing, is often an early symptom of DRESS and is often associated with gout
http://www.eblue.org/article/S0190-9622(13)01021-9/abstract
http://www.ehealthme.com/cs/gout/dysphagia

Uric Acid and the Th2 of the immune system
http://www.jimmunol.org/content/192/9/4032.full
http://www.sciencedirect.com/science/article/pii/S1074761311001221

wells syndrome is eosinophilic cellulitis
http://emedicine.medscape.com/article/1124844-overview

cyclosporine treats wells syndrome possibly by acting on T helper cells
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057600/pdf/11641541.pdf

Cyclosporine is known to resolve DRESS syndrome
http://www.ncbi.nlm.nih.gov/pubmed/16114793
http://www.ncbi.nlm.nih.gov/pubmed/20110143

However one does not have to have an infection to have gout and  DRESS. One could merely be an alcoholic.

Note that the relationship between gout and alcohol have been known since Henry the VIII. Alcohol especially beer's purines raises the lactic acid levels of the body.  When lactic acid levels are high uric acid is not secreted and causes gout.  Alcohol itself is secreted instead of uric acid by the kidney when levels are high.