The notion that there are 3 zones the immune system identifies is also supported by memory cells. B cells which have been educated to know the outside of cells can create B memory cells for antigens it doesn't recognize. The T cells which have been educated for internal antigens must also create memory cells but since there are two internal zones: the cytosol zone and then the nuclear/mito zone and these zones are fought differently two types of T memory cells emerge.
Peripheral tissues have Tissue Resident memory cells (TRM) cd103
which are the cd8 memory cells that can quickly secrete Granzyme B become CTL cells
they are responsible for mitochondrial or nuclear antigen recognition
The lymph organs have the Central memory T cells (CMT ) cd44
which are the cd4 memory cells which quickly secrete il-2
they are responsible for the cytosol antigen recognition
The traveling memory T cells can be cd8 or cd4 moving between the tissues and the lymphs. They produce IFNgamma for inside antigens or il-4/il-5 for outside antigens.
This is the logical hypothesis but is there evidence?
il-2 would differentiate CTL with fas and TH1 ?
cd4 not cd8 T cell proliferation altered by anti-cd44
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782945/
Tissue resident T cells TRM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879098/
Il-2 and T memory cells
http://jem.rupress.org/content/204/3/547
When there are cytosol infections the CTL cells express Fas.
example: the flu which is a cytosolic virus triggers FasL expression in infected cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073994/
Possible?
Tcm and Leishmania
https://www.ncbi.nlm.nih.gov/pubmed/15448686?dopt=Abstract
Leishmania parasite in cytosol of host
https://genomebiology.biomedcentral.com/articles/10.1186/gb-2008-9-2-r35
nuclear viruses EBV and CMV with Tissue resident memory cells
https://www.ncbi.nlm.nih.gov/pubmed/27540722
Are central memory cells from the T cells in the follicular position?
Although B And T memory cells are always produced each pathway has a primary memory path. Nuclear antigens would have tissue resident memory T cells. Cytosol antigens would have central memory T cells. Outer antigens would have B memory cells. This is based on the size of proliferation.
Review of Antibody production hypothesis in the lymph node/spleen.
Peripheral tissues have Tissue Resident memory cells (TRM) cd103
which are the cd8 memory cells that can quickly secrete Granzyme B become CTL cells
they are responsible for mitochondrial or nuclear antigen recognition
The lymph organs have the Central memory T cells (CMT ) cd44
which are the cd4 memory cells which quickly secrete il-2
they are responsible for the cytosol antigen recognition
The traveling memory T cells can be cd8 or cd4 moving between the tissues and the lymphs. They produce IFNgamma for inside antigens or il-4/il-5 for outside antigens.
This is the logical hypothesis but is there evidence?
il-2 would differentiate CTL with fas and TH1 ?
cd4 not cd8 T cell proliferation altered by anti-cd44
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782945/
Tissue resident T cells TRM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879098/
Il-2 and T memory cells
http://jem.rupress.org/content/204/3/547
il-2 or il-12 can differentiate TH1 cells
http://www.jimmunol.org/content/170/2/735
CD4 Th1 differentiation and memory cells
http://www.jimmunol.org/content/170/2/735
CD4 Th1 differentiation and memory cells
https://www.exphem.org/article/S0301-472X(16)30189-8/fulltext
il-2 CTL differentiation
http://www.jimmunol.org/content/162/11/6466
il-2 CTL differentiation
http://www.jimmunol.org/content/162/11/6466
When there are cytosol infections the CTL cells express Fas.
example: the flu which is a cytosolic virus triggers FasL expression in infected cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073994/
Tcm and Leishmania
https://www.ncbi.nlm.nih.gov/pubmed/15448686?dopt=Abstract
Leishmania parasite in cytosol of host
https://genomebiology.biomedcentral.com/articles/10.1186/gb-2008-9-2-r35
nuclear viruses EBV and CMV with Tissue resident memory cells
https://www.ncbi.nlm.nih.gov/pubmed/27540722
Are central memory cells from the T cells in the follicular position?
Although B And T memory cells are always produced each pathway has a primary memory path. Nuclear antigens would have tissue resident memory T cells. Cytosol antigens would have central memory T cells. Outer antigens would have B memory cells. This is based on the size of proliferation.
Review of Antibody production hypothesis in the lymph node/spleen.
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