The ox40 ligand appears on activated cells. When the T cells finally express ox40 it must determine or verify which of the 3 zones are active.
The ox40L appears as members of a team become activated. Ideally only one team is on at a time. The T cells which travel between the inflammation and the lymph, talk to the rest of the immune system, and are responsible for telling the B cells which antibody to make verifies which pathway is in progress.
So what happens in autoimmune disease when 2 of these pathways are activated at the same time on one target tissue: flu virus (cytosol) and e.coli (outside) on the pancreas triggering autoimmune diabetes.
The natural Tregs that focus the pathway reactions are not activated? unclear
https://www.ncbi.nlm.nih.gov/pubmed/30021159
The cytokines and cytokine receptors delineating the teams
The ox40L appears as members of a team become activated. Ideally only one team is on at a time. The T cells which travel between the inflammation and the lymph, talk to the rest of the immune system, and are responsible for telling the B cells which antibody to make verifies which pathway is in progress.
So what happens in autoimmune disease when 2 of these pathways are activated at the same time on one target tissue: flu virus (cytosol) and e.coli (outside) on the pancreas triggering autoimmune diabetes.
The natural Tregs that focus the pathway reactions are not activated? unclear
https://www.ncbi.nlm.nih.gov/pubmed/30021159
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