LEC educates on local antigens before allowing cells into lymph gland

LEC educates on local antigens before allowing cells into lymph gland

Tolerance is the "self education" given the B and T cells. B cells have been taught the external antigens in the bone marrow while T cells have learned the internal DNA/RNA antigens in the thymus. These self educations where all genes are expressed are called Central Tolerance.

Peripheral Tolerance is given to B and T cells by the gatekeeper cells of the lymph glands: the Lymphatic Endothelial cells.  Lymphatic endothelial cells express the tissue specific genes of the cells of their area. They also sample and wear the antigens commonly found in their area.

These lymphatic endothelial cells will only allow in T and B cells that do not react with the self antigens specific to the tissues of the of the peripheral area into the lymph gland.  (B cells are hypothesized to be educated too but this is not proven)

Current ideology is that if we can get antigens from a transplanted organ into the LEC tolerance to the transplanted organ will occur. The question is how is this done exactly and how often do LEC update their antigens.

lymphatic endothelial cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226940/

bone marrow cells
http://www.jimmunol.org/content/196/1_Supplement/55.28

VEC and BEC express their areas antigens
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137938/

LEC have mhc1 and mhc2
https://www.jci.org/articles/view/73316