The B7 ligands inform the T cell which pathway to take: to become follicular T cells or to become regulator Tcells then as a T follicular to find a B cell to make antibodies. B7 when binding CTL-4 can also slowly stop the reactions.
Capture of Antigen by BCR of B cell from FDC
https://www.ncbi.nlm.nih.gov/pubmed/19506051
cd169 macrophages APC (these are the SCS of the lymph and the metallophillic macrophage of the spleen)
https://onlinelibrary.wiley.com/doi/full/10.1002/eji.201444983
THfollicular Th1 to Tfh1 or Th2 to Tfh2 ?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193096/
Does B7-2 on APC cause the conversion of Th1 or Th2 to the follicular type of T cell? Tfh1 and Tfh2?
B7-2 and follicular T cell development
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089765/
B7-2 is on Langerhans, medial zone B cells, macrophages, and dendritic cells which bring the antigens to the lymph or spleen
B7-1 is on the follicular B cell that presents to the follicular T cell that with TCR stimulation activates the T cell and Icos is expressed.
(B7-1 is also on activated T cells and activated macrophages)
Pd-L is increased with ifn gamma on cd4 and cd8 cells so they can interact with the myeloid or plasmacytoid dendritic cells.
B7-DC(pd-L1) on myeloid dendritic
B7-H1 (pd-L2) plasmacytoid dendritic
B7-1 (cd80) follicular B cells which present
B7-2 (cd86) Langerhans, macrophages, dendritic cells, and marginal zone B cells (antigen carriers)
where the Th1 is actually a follicular Th1 and the Tc is a follicular Tc. Note that I am not showing the interaction of the inner antigens on the scs macrophages antigen presenting to the B cells BCR.
CD8 T cells becoming follicular like
https://www.ncbi.nlm.nih.gov/pubmed/29743314
The notion that B7-2 tells the T cells to become follicular is logistical. The antigen carrier wearing B7-2 informs the T cell that we have the antigen so please find an antigen presenter, a B cell and make antibodies with them.
in the absence of additional dendritic/antigen carrying cells the T cells having seen APC can't make il-21 ( become follicular?)
https://www.ncbi.nlm.nih.gov/pubmed/21715693/
Is this the B7-2 ?
Tfollicular cells and autoimmune disease
https://www.bioportfolio.com/resources/trial/161554/Study-the-Role-of-T-Lymphocytes-in-Autoimmune-Hemolytic-Anemia.html
Capture of Antigen by BCR of B cell from FDC
https://www.ncbi.nlm.nih.gov/pubmed/19506051
cd169 macrophages APC (these are the SCS of the lymph and the metallophillic macrophage of the spleen)
https://onlinelibrary.wiley.com/doi/full/10.1002/eji.201444983
THfollicular Th1 to Tfh1 or Th2 to Tfh2 ?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193096/
Does B7-2 on APC cause the conversion of Th1 or Th2 to the follicular type of T cell? Tfh1 and Tfh2?
B7-2 and follicular T cell development
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089765/
B7-2 is on Langerhans, medial zone B cells, macrophages, and dendritic cells which bring the antigens to the lymph or spleen
B7-1 is on the follicular B cell that presents to the follicular T cell that with TCR stimulation activates the T cell and Icos is expressed.
(B7-1 is also on activated T cells and activated macrophages)
Pd-L is increased with ifn gamma on cd4 and cd8 cells so they can interact with the myeloid or plasmacytoid dendritic cells.
B7-DC(pd-L1) on myeloid dendritic
B7-H1 (pd-L2) plasmacytoid dendritic
B7-1 (cd80) follicular B cells which present
B7-2 (cd86) Langerhans, macrophages, dendritic cells, and marginal zone B cells (antigen carriers)
where the Th1 is actually a follicular Th1 and the Tc is a follicular Tc. Note that I am not showing the interaction of the inner antigens on the scs macrophages antigen presenting to the B cells BCR.
CD8 T cells becoming follicular like
https://www.ncbi.nlm.nih.gov/pubmed/29743314
The notion that B7-2 tells the T cells to become follicular is logistical. The antigen carrier wearing B7-2 informs the T cell that we have the antigen so please find an antigen presenter, a B cell and make antibodies with them.
in the absence of additional dendritic/antigen carrying cells the T cells having seen APC can't make il-21 ( become follicular?)
https://www.ncbi.nlm.nih.gov/pubmed/21715693/
Is this the B7-2 ?
Tfollicular cells and autoimmune disease
https://www.bioportfolio.com/resources/trial/161554/Study-the-Role-of-T-Lymphocytes-in-Autoimmune-Hemolytic-Anemia.html
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