Monday, January 7, 2019

Contemplations of IgG2 and IgG3 antibodies


When it comes to viruses IgG2 binds cytosolic viruses and IgG3 binds mitochondrial and nuclear viruses but what happens when bacterias and parasites move inside of the host cell? Which IgG antibodies are involved?

Cytosol infections : mycobacteria and fungus

IgG2 and mycobacteria
https://cvi.asm.org/content/10/1/88

IgG2 and cryptococcus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828574/

cryptococcus neuformans (fungus) in the cytosol of cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127716/

IgG3 and bacteria? complement?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979173/

Vacuole/golgi bacteria or parasites hypothesis involves TH17 il-22 or il-24 to pop them and does this involve IgG3?

il-17 and il-22 with leishmaniasis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719936/

IgG3 and il-10 with leishmaniasis

plasmacytoid dendritic cells and leishmaniasis ?
https://www.ncbi.nlm.nih.gov/pubmed/17705130

IgG3 and listeria
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC201853/

listeria and vacuoles
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006734

pDendritic cells and listeria ?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078036/


IgG3 and Follicular dendritic cells
https://www.nature.com/articles/s41598-017-05704-3

This would loop back to the outside antigens (after the bacteria was released from internal regions and allow Somatic hypermutation against the now visible bacteria/parasite)

IgG3 complexes are bound by Neutrophils 3x faster than IgG1
https://www.ncbi.nlm.nih.gov/pubmed/2784461

note that il-17A calls neutrophils
https://www.nature.com/articles/mi201680








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