Autoimmune liver disease or autoimmune hepatitis caused by Cross-targeting autoimmunity?

Dedicated in loving memory to my dear friend Sue.  

Hypothesis: Cross-targeting autoimmunity occurs when 2 infections, one being a virus, infect the same target.  This state causes the immune system to escalate the immune attack into autoimmunity because both the inside and the outside of the organ is marked as infected.


2 types of autoimmune liver disease and the overlapping syndromes:
http://www.ncbi.nlm.nih.gov/pubmed/19212308

3 types of autoimmune liver disease
http://www.ncbi.nlm.nih.gov/pubmed/16989180

1.Autoimmune Hepatitis (AIH) and celiac disease
http://www.ncbi.nlm.nih.gov/pubmed/15645466 
note that I have celiac disease associated with one form of e.coli.  E.coli make bilirubin when it breaks down RBC which could produce antibodies against the liver who also makes bilirubin.  I am suggesting that someone out there look for these anti-bilirubin antibodies in these types of cases. 

2.Primary (Autoimmune) Sclerosing Cholangitis
PSC with IBS

 If the IBS is not crohn's or ulcerative colitis is it microscopic colitis? which could be fungal?
http://angelabiggs.blogspot.com/2013/05/microscopic-colitis.html

If we divide these into separate types:
primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC)
with PBC found more in women and being the fungal type then what causes PSC?

PSC and RA? mycoplasmas and cancer?
http://www.ncbi.nlm.nih.gov/pubmed/23868731  (PSC and RA )
http://www.ncbi.nlm.nih.gov/pubmed/24637212 (liver, mycoplasma, cancer)

RA and mycoplasmas (old post)
http://angelabiggs.blogspot.com/2013/04/lupus-and-ra-leukemia-and-mycoplasmas.html

I have a strong overlap with mycoplasmas and autoimmune hemolitic anemia
http://angelabiggs.blogspot.com/2014/06/autoimmune-hemolytic-anemia-and-cross.html

The obvious viral triggers causing the the cross-targeting are hepatitis A, B, and C.  They do not not cause the autoimmune disease alone. Only if an infection or anti-bodies preexist against the liver.

Alzheimer's mitochondria damage from herpes or Diacteyl...which one causes the eye plaques?

 reposting and updating:

This post specific is not focused on an autoimmune disease but Alzheimer's.  I am looking at the  notion of amyloid plaques and the mitochondria.  A continuation of the the Alzheimer's and parkinson's posts. Where it is the destruction of the mitochondria that is key to the development of the diseases.

amyloidosis and the mitochondria (genetic)
http://www.ncbi.nlm.nih.gov/pubmed/19018796
http://www.nature.com/ejhg/journal/v18/n8/full/ejhg201036a.html

amyloidosis, Karposi's, and herpes (non genetic)
http://www.ncbi.nlm.nih.gov/pubmed/10842716
http://www.ncbi.nlm.nih.gov/pubmed/498024 
herpes virus 8 with karposi? Alzheimer's is connected to herpes virus 1

Herpes destroys host's mitochondrial DNA
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1796774/
the herpes virus drives the mitochondria down the nerve root to other nerves!
http://www.sciencedirect.com/science/article/pii/S1931312812001047 
herpes causes amyloid
http://www.ncbi.nlm.nih.gov/pubmed/17980964
http://www.ncbi.nlm.nih.gov/pubmed/16109164
 
 Herpes and Alzheimer's Patients
http://www.ncbi.nlm.nih.gov/pubmed/18973185
http://www.ncbi.nlm.nih.gov/pubmed/22216291
http://www.ncbi.nlm.nih.gov/pubmed/18982063
http://www.ncbi.nlm.nih.gov/pubmed/23261465 

Herpes and APO-e
http://www.ncbi.nlm.nih.gov/pubmed/9014911

in Cardiac tissue? similar to nerves?
http://www.ncbi.nlm.nih.gov/pubmed/24182678 

Popcorn diacetyl and bronchiolitits obliterans....are amyloids there?
http://www.ncbi.nlm.nih.gov/pubmed/12151470
http://www.ncbi.nlm.nih.gov/pubmed/17541015
http://www.ncbi.nlm.nih.gov/pubmed/17464280
http://www.ncbi.nlm.nih.gov/pubmed/18772104
 http://www.livescience.com/22308-new-microwave-popcorn-chemical-linked-to-lung-damage.html

http://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17541015&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVLinkOut 

Renal amyloid after bronchioltitis ?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004490/

At this point  I am looking at or for evidence that herpes or diacetyl destroys the mitochondria causing amyloid plaques in similar ways.

Here is the link to an older post looking at the overlap of Alzheimer's & Parkinson's
http://angelabiggs.blogspot.com/2013/09/alzheimers-parkinsonstourettes-how-do.html 

Genetic forms of Alzheimer's and mitochondria damage (not herpes or diacetyl but mitochondria is key)
http://www.ncbi.nlm.nih.gov/pubmed/24569455 

Mother's of Downsyndrome children have increased risk of Alzheimer's (more evidence of faulty mitochondrias)
http://www.ncbi.nlm.nih.gov/pubmed/7914304
http://www.ncbi.nlm.nih.gov/pubmed/11571320
http://www.ncbi.nlm.nih.gov/pubmed/10402505

 NEW:
 I am looking at the new diagnosis of Alzheimer's using cumin to identify amyloid in the patients eye which causes amyloid cataract. http://newyork.cbslocal.com/2014/07/13/researchers-report-breakthroughs-in-diagnosis-of-alzheimers-disease/
 
age cataracts vs amyloid cataracts
 http://blog.alz.org/age-related-cataracts-vs-amyloid-cataracts-a-distinction/

Which conditon causes this? herpes or diacetyl consumption? 

this comment added may 2016: herpes viruses use estrogen receptors and estrogen receptors are on the lens
http://www.ncbi.nlm.nih.gov/pubmed/24987869  (beta estrogen receptors cycle to the mitochondria)
http://www.ncbi.nlm.nih.gov/pubmed/8285900

type one diabetes and cross-targeting autoimmunity update

Type one diabetes and the infections of the pancreas. What are the cross-targeting culprits? Does one infection cross-targeted with a virus in the pancreas trigger the autoimmune disease? Like Candida and the flu?

Eisenbarth's Autoimmune Polyendocrine Syndrome Type 1 (APS-I)

Candida
http://www.ucdenver.edu/academics/colleges/medicalschool/centers/BarbaraDavis/Documents/book-Type1DiabetesHTML/type1_ch8.html

Candida infects the pancreas
http://www.ncbi.nlm.nih.gov/pubmed/7944045


Eisenbarth's APS-2 could be bacterial infections  of the pancreas

E.coli infects the pancreas directly
http://gut.bmj.com/content/35/9/1306.full.pdf 

e.coli in the guts of Type 1 diabetes patients
http://www.ncbi.nlm.nih.gov/pubmed/24475780 

History of bladder infections in celiac patients
http://www.ncbi.nlm.nih.gov/pubmed/22185967
note that e.coli often causes bladder infections...so does e.coli have the ability to generate anti-insulin or does it infect the pancreas directly?

Mycoplasmas from Lupus/rheumatoid arthritis infects the pancreas directly
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1412106/

But the autoimmunity does not develop until cross-targeting occurs with a virus
Now for the Viruses:
The flu virus replicates in the pancreas and so does the coxsackie virus.

coxsackie
http://www.ncbi.nlm.nih.gov/pubmed/9257948

flu
http://www.everydayhealth.com/cold-and-flu/1105/flu-virus-may-trigger-diabetes.aspx
http://www.ima.org.il/FilesUpload/IMAJ/0/40/20206.pdf


Interesting 2013 article that supports the celiac and Ecoli connection:
http://www.nytimes.com/2013/02/24/opinion/sunday/what-really-causes-celiac-disease.html?smid=fb-share

One of my 2012 posts:
http://angelabiggs.blogspot.com/2012/10/blog-post.html

Does cross-targeting cause the autoimmune disease Kinsbourne syndrome or Opsoclonus Myoclonus Syndrome (OMS)?

Hypothesis: Cross-targeting autoimmunity occurs when 2 infections, one being a virus, infect the same target.  This state causes the immune system to escalate the immune attack into autoimmunity because both the inside and the outside of the organ is marked as infected.


Kinsbourne syndrome or Opsoclonus Myoclonus Syndrome (OMS)

http://www.ncbi.nlm.nih.gov/pubmed/24995204

west nile virus
http://www.ncbi.nlm.nih.gov/pubmed/24968889
http://www.ncbi.nlm.nih.gov/pubmed/16966514
http://www.ncbi.nlm.nih.gov/pubmed/24987503
http://www.ncbi.nlm.nih.gov/pubmed/24688189

What organ is the target? the nerves?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528292

(west nile and polio like paralysis ? http://www.ncbi.nlm.nih.gov/pubmed/17168167  http://www.ncbi.nlm.nih.gov/pubmed/12929189)

Strep A
http://www.ncbi.nlm.nih.gov/pubmed/17414405
http://www.ncbi.nlm.nih.gov/pubmed/12886983
http://www.ncbi.nlm.nih.gov/pubmed/17486621

Strep would break the blood brain barrier letting the virus through or can the virus get there alone? Kinsbourne is an autoimmune disease attack on brain cells (neurons)...so is it the cross-targeting of strep A and west nile virus?

Adrenal glands and west nile  virus
http://www.ncbi.nlm.nih.gov/pubmed/16896857
http://www.sart.org/uploadedFiles/ASRM_Content/News_and_Publications/Practice_Guidelines/Position_Statements/ASRM_SART_position%281%29.pdf

Neuroblastoma is associated with
Opsoclonus Myoclonus Syndrome (OMS) and with starting in the adrenal glands. Does the west nile virus play a role in the development of this form of cancer?