Hypotheses: Autoimmune Cross-targeting, Co-carcinogenesis, and Quorum complications : 2014

Monday, December 8, 2014

Is endometriosis an autoimmune disease or just a mycobacteria disease?

This doesn't appear to be an autoimmune and cross-targeting does not appear to be involved. Mycobacterias do seem to be the common thread to other diseases including autoimmune ones.

This is a hypothesis blog and this is not proven.

endometriosis with psoriasis and crohn's
http://www.ncbi.nlm.nih.gov/pubmed/11476764
crohn's
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718912/
http://www.ncbi.nlm.nih.gov/pubmed/10741938
http://www.ncbi.nlm.nih.gov/pubmed/9412916
http://www.ncbi.nlm.nih.gov/pubmed/1858741
psoriasis connection with angiogensis
http://www.ncbi.nlm.nih.gov/pubmed/10027628
http://www.ehealthme.com/cs/psoriasis/endometriosis

Crohn's and mycobacteria
http://www.ncbi.nlm.nih.gov/pubmed/18043227
http://www.ncbi.nlm.nih.gov/pubmed/18609156
http://www.birdflubook.org/resources/herman-taylor3.pdf

psoriasis and mycobacteria
http://www.ncbi.nlm.nih.gov/pubmed/23675972
http://www.ncbi.nlm.nih.gov/pubmed/23094309

mycobacteria and endometriosis
http://www.ncbi.nlm.nih.gov/pubmed/14725567

rare case? TB and endometriosis
http://www.ncbi.nlm.nih.gov/pubmed/17936277
http://www.ncbi.nlm.nih.gov/pubmed/10589410

consider that leprosy which is a mycobacteria of the skin causing the skin to "grow out of control " might be similar in cytokines etc....nerve growth factor here seems to be involved
http://www.ncbi.nlm.nih.gov/pubmed/25457797

endometriosis and nerve growth factor is over expressed
http://www.ncbi.nlm.nih.gov/pubmed/24121693

Mast cells and endometriosis
http://www.ncbi.nlm.nih.gov/pubmed/24022937

mast cells and mycobacteria
http://www.ncbi.nlm.nih.gov/pubmed/12759438
not obvious that NGF is involved

When endometriosis overlaps fibromylagia it could be a completely different infection:
http://angelabiggs.blogspot.com/2014/06/endometriosis-and-autoimmune-disease.html

Thursday, December 4, 2014

t.gondii and cytomegalovirus are both associated with schizophrenia and hearing loss in newborns

Tuesday, November 25, 2014

Buerger's disease ( thromboangiitis obliterans)...can it be caused by autoimmune cross-targeting?

Not to be confused with Berger's disease (IgA nephropathy)

Buerger's disease or thromboangiitis obliterans is an autoimmune disease of the vascular system.
http://www.ncbi.nlm.nih.gov/pubmed/2808505
http://www.ncbi.nlm.nih.gov/pubmed/6392910

Hypothesis: The cross-targeting of infections at the same tissue causes autoimmune disease. One infection marks the outside while another marks the inside...only then does the immune system become confused and attack. A virus marks the inside of the vascular cells while an infection marks the outside.

Is it Rickettsia?
http://www.ncbi.nlm.nih.gov/pubmed/21803838
http://www.ncbi.nlm.nih.gov/pubmed/6897655
http://www.ncbi.nlm.nih.gov/pubmed/6893791

Rocky mountain spotted fever, rickettsia, and kidney failure
http://www.ncbi.nlm.nih.gov/pubmed/434998
http://www.ncbi.nlm.nih.gov/pubmed/1996579
http://www.ncbi.nlm.nih.gov/pubmed/9003109

Gangrene and Rocky mountain spotted fever
http://www.ncbi.nlm.nih.gov/pubmed/8507753
http://www.ncbi.nlm.nih.gov/pubmed/7748070

IMPORTANT: Tobacco use can cause antibodies which may mean this is the first autoimmune disease that may not require 2 infections for cross-targeting to occur!!!
http://www.ncbi.nlm.nih.gov/pubmed/1598672
http://www.ncbi.nlm.nih.gov/pubmed/6426348

smokeless tobacco extract changes vascular cells
http://www.ncbi.nlm.nih.gov/pubmed/10708806

So the parasite would make the outside and the tobacco chemical would mark the inside?

Here is a Virus triggering the Buerger's: Coxsackie virus

http://www.ncbi.nlm.nih.gov/pubmed/2868678

Buerger's overlaps with takayasu and juvenile arthritis

http://www.ncbi.nlm.nih.gov/pubmed/9951798
http://www.ncbi.nlm.nih.gov/pubmed/13679660

Mycobacteria and juvenile arthritis mice?????? not sure where i am
http://www.ncbi.nlm.nih.gov/pubmed/24470407

Sunday, November 23, 2014

Autoimmune cross-targeting could cause Rheumatoid arthritis

Autoimmune cross-targeting hypothesis: that the layering of 2 infections on one target confuses the immune system into autoimmune attack. A viral infection like hepatitis marks the inside and mycoplasmas mark the outside in the case of RA.

Mycoplasmas and RA
http://www.ncbi.nlm.nih.gov/pubmed/24097830
http://www.ncbi.nlm.nih.gov/pubmed/10618069 (infection found in synovial fluid)
http://www.ncbi.nlm.nih.gov/pubmed/17122006

Not a new idea 1971...mycoplasmas and RA
http://www.ncbi.nlm.nih.gov/pubmed/5165178

Synovial membrane antibodies and RA
http://www.ncbi.nlm.nih.gov/pubmed/16184347

Virus: hepatitis and RA
http://www.ncbi.nlm.nih.gov/pubmed/25415338
http://rheumatology.oxfordjournals.org/content/38/10/978.full (after hepatitis vaccine RA)

Virus: epstein barr and RA
http://www.ncbi.nlm.nih.gov/pubmed/25407647

Note that it is the target and the layering of infections pointing the immune system at the target that is is important in the development of autoimmunity. Either virus could trigger the event.

Older posts
http://angelabiggs.blogspot.com/2014/09/ra-stroke-irregular-heartbeats-and.html
http://angelabiggs.blogspot.com/2013/04/lupus-and-ra-leukemia-and-mycoplasmas.html

Thursday, November 20, 2014

Vaccines and autoimmune disease: the viruses are only half the issue and this cross-targeting hypothesis will help find the other culprits.

GET VACCINATED !!!!! This blog believes that preventing viral infection is your best defense.

Cross-targeting hypothesis: the immune system must cross-target itself on one target with 2 different infections before it is willing to attack self. Autoimmunity develops only when a virus is layered on top of another infection thus confusing the immune system.

Example: mycoplasmas of RA infect the pancreas and then the flu virus replicates there triggering the autoimmunity...or e.coli make anti-insulin antibodies and then the flu replicates there....causing type 1 diabetes.

Possible? If this is true we need to know what infections existed in the target tissue of the people who develop autoimmunity after vaccines. Does sutterellla the bacteria suspect in some autistic children hang out in the same nerves that the measles vaccine targets? Sutterella has been found in the brain. Very few areas in the us will have an issue with the vaccine triggered form of autism most will be antibodies from the mother which cause the autism. Sutterella is found in areas where the sewers over flow into the areas waters.....NOT COMMON.

Note that it is the antibodies from the vaccines that can trigger the autoimmune disease. A good vaccine won't have them....this should be preventable if you know what you are looking for.

This Blog post will slowly try to collect information about the vaccine triggered autoimmune diseases and will be updated over time. Note that when a vaccine has issues...they are not used and improved.

Yellow fever vaccine
http://www.hindawi.com/journals/ad/2014/473170/

HPV
http://www.ncbi.nlm.nih.gov/pubmed/25388965

hepatitis vaccine
http://www.ncbi.nlm.nih.gov/pubmed/22235045
http://www.ncbi.nlm.nih.gov/pubmed/25042822 (murine model)
http://rheumatology.oxfordjournals.org/content/38/10/978.full (RA after hepatitis vaccine)

H1N1
http://www.ncbi.nlm.nih.gov/pubmed/21994316
http://www.ncbi.nlm.nih.gov/pubmed/23498095

MMR and autism...the confusion
http://www.ncbi.nlm.nih.gov/pubmed/11331734

Tuesday, November 18, 2014

autoimmune cross-targeting and Meniere's disease of the inner ear

Hypothesis: The cross-targeting of infections at the same tissue causes autoimmune disease. One infection marks the outside while another marks the inside...only then does the immune system become confused and attack. A virus like herpes marks the inside of the cell while an infection such as candida marks the outside....the target cell in this case is the labyrinthectomy or vestibular nerve of the inner ear.

There could be more than one infection that triggers. The Key is one must be a virus and one an outer infection.

Meniere's as an autoimmune disease

http://www.sciencedirect.com/science/article/pii/S1568997212000092

gluten with candida not celiac
http://www.ncbi.nlm.nih.gov/pubmed/19549274
http://www.ncbi.nlm.nih.gov/pubmed/12383098

(note that for a while on this blog I thought gluten/casein indicated a dimorphic infection but LON the enzyme responsible for switching is not gluten sensitive so the new hypothesis that gluten and casein cause inflammation in barrier crossing infections.)

Hypothyroid with meniere's
http://www.ncbi.nlm.nih.gov/pubmed/14967756

blog post connecting Hashimoto's thyroid, sjogren's, and asperger's (fungal)
http://angelabiggs.blogspot.com/2013/08/aspergers-sjogren-and-hosimotos-overlap.html

Sjogren's, water channels, and meniere's
http://www.ncbi.nlm.nih.gov/pubmed/22732097
http://www.ncbi.nlm.nih.gov/pubmed/19096777
http://www.ncbi.nlm.nih.gov/pubmed/16974147
http://www.ncbi.nlm.nih.gov/pubmed/23382834

Candida, biofilms and waterchannels (biofilm is how it sticks to the walls)
http://www.ncbi.nlm.nih.gov/pubmed/15496122
http://www.ncbi.nlm.nih.gov/pubmed/11526156

Dividing up: Autistic development disorders, adhd, and asperger's

Hypothesis: These will be found to be autoimmune diseases caused initially by cross-targeting autoimmunity.

At least 4-5 types of development disorders exist: Immediate autism, regressive autism, ADHD, and asperger's

Immediate Autism: has seizures, anxiety, delayed or absent development of social skills. (In this case the child is born with autism and the frontal lobe has antibodies against it and grows abnormally.

rheumatoid arthritis in mother's and autism
http://www.ncbi.nlm.nih.gov/pubmed/19581261 (lupus?)
http://www.ncbi.nlm.nih.gov/pubmed/10385847
http://sfari.org/news-and-opinion/news/2013/large-study-links-autism-to-autoimmune-disease-in-mothers
http://www.ncbi.nlm.nih.gov/pubmed/23958959
http://www.ncbi.nlm.nih.gov/pubmed/23910451

Lupus seems connected to dyslexia
http://www.ncbi.nlm.nih.gov/pubmed/3205905
http://www.ncbi.nlm.nih.gov/pubmed/18593761

Newer post looks at seizures and and lupus as possibly caused by antibodies.

Posts of mine connecting RA,lupus and mycoplasmas
http://angelabiggs.blogspot.com/2014/11/autoimmune-cross-targeting-could-cause.html
http://angelabiggs.blogspot.com/2013/04/lupus-and-ra-leukemia-and-mycoplasmas.html
http://angelabiggs.blogspot.com/2014/09/ra-stroke-irregular-heartbeats-and.html

bipolar with autism (not depression or hypothyroid rather hyperthyroid)
http://www.ncbi.nlm.nih.gov/pubmed/18378000

In this case mother's autoimmunity attacks child's brain
http://www.ncbi.nlm.nih.gov/pubmed/23958959
http://www.ncbi.nlm.nih.gov/pubmed/18571628
http://www.ncbi.nlm.nih.gov/pubmed/18078998

Regressive autism: Childhood disintegrative disorder is when the child suddenly loses skills after viral trigger (or vaccine) which is a very small group.

Are there 2 groups here? gluten sensitive sutterella group which reacted to the MMR then the hearing impaired group which reacted to the DTP? Please see the new posts where I have divided these up better.

Group one: MMR and sutterella cross-targeting on the cerebellum. Ataxia issues are involved.
Is this the sutterella group with the clusters in NJ and Hawaii? where the sewers are overflowing and a fecal bacteria could spread) Autoimmune cross-targeting form of autism where the nerves targeting by the vaccine are the same ones the sutterella likes. (sutterella exists in intestine and has been found in brain
http://www.ncbi.nlm.nih.gov/pubmed/24188502
http://www.ncbi.nlm.nih.gov/pubmed/19027584 (children have intestinal issues)

Sutterella is rare....get your kids VACCINATED

only the kids with sutterella bacteria would react with the vaccine...through cross-targeting autoimmunity
http://www.ncbi.nlm.nih.gov/pubmed/11331734

My old post on Autism and sutterella might not be correct because the Lon enzyme has been tested and it is not morphology change from gluten.
http://angelabiggs.blogspot.com/2013/07/is-sutterella-dimorphic.html
The new post about gluten and casein considers sutterella as breaking the intestinal and brain barriers.
http://angelabiggs.blogspot.com/2014/09/if-all-gluten-and-casein-senstive.html

Group 2 regressive: the DTP and 6th disease cross-targeting on the temporal lobe. Hearing issues are involved. See new post.

ADHD is when the child has hyperactivity, tics, and attention issues...Eczema and staph?

ADD and bipolar
http://www.ncbi.nlm.nih.gov/pubmed/9680053

ADHD and tics ( if tourettes is triggered by strep what is this staph?)
http://www.ncbi.nlm.nih.gov/pubmed/14580223
http://www.ncbi.nlm.nih.gov/pubmed/16780292

ADHD with asthma and allergies
http://www.brainbalancecenters.com/blog/2013/08/study-adhd-linked-to-asthma-and-allergies/
ADHD with eczema which could be staph
http://www.everydayhealth.com/eczema/the-eczema-and-adhd-connection.aspx
http://www.ncbi.nlm.nih.gov/pubmed/24289041

Autism and hyperactivity
http://www.ncbi.nlm.nih.gov/pubmed/17201617

Asperger's has hypothyroid, sjogren's and fungal infection connections
antisocial but gifted abilities in math, music, or art
unusual speech patterns and sensitive to smell or touch

ADHD and hypothyroid
http://www.ncbi.nlm.nih.gov/pubmed/12573298
not linked to hyper trait

Antisocial and substance abuse
http://www.ncbi.nlm.nih.gov/pubmed/19515234

asperger's and hashimoto's the older post
http://angelabiggs.blogspot.com/2013/08/aspergers-sjogren-and-hosimotos-overlap.html

asperger's and bipolar
http://www.ncbi.nlm.nih.gov/pubmed/25046741

Pervasive developmental disorder is when the child has developmental delays but too social to be autistic ...seems like this would fall into the adhd group??

Friday, November 7, 2014

Overlap of Mycobacterias, type 2 diabetes, crohn's, parkinson's, and psoriasis

Tuesday, November 4, 2014

3 types of Schizophrenia : 2 are cross-targeting autoimmunity and one is tumor created antibodies

This blog focuses primarily on cross-targeting autoimmunity. In the case of schizophrenia it has become apparent that at least 2 types exist that involve infections cross-targeting with viral infections.

Fungal infections could cause manifest with other autoimmune diseases like Sjogern's, Asperger's, and Hashimotos thyroid. These fungal infections are dimorphic thus causing the person to have sensitivities to corn, soy, and estrogen. Dimorphic means that they shift as a fungal infection between a yeast and a mold state of morphology. An example of a fungal infection is Candida. The fungal infection might break the blood brain barrier allowing a virus like cmv into the brain. The key is that these ,unlike T.gondii, would be estrogen sensitive.

Schizophrenia has also been associated with T.gondii infections which trigger strong gluten and casein sensitivities. There appears to be gluten and casein sensitivities when small infections cross barriers like the intestine or the blood brain barrier....or at least that is my prediction.

I had contrasted Asperger's and schizophrenia looking at both of these infections before.
http://angelabiggs.blogspot.com/2014/04/aspergers-and-schizophernia-both.html
asperger's with schizophrenia
http://www.ncbi.nlm.nih.gov/pubmed/23065028
http://link.springer.com/article/10.1007%2Fs00787-012-0338-x#page-1

This page is under construction as I organize references and explain my thoughts for linking them.

The Cross-targeting hypothesis: when a viral infection overlaps a basic infection on/in one cell type, in this case neurons, thus confusing the immune system and generating an autoimmune attack against self.

First Schizophrenia has 2 core autoimmune antibodies:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065649/
Voltage gated potassium channels and then the NMDA receptor. The larger infections tend to generate these antibodies while the viruses tend to infect the neurons themselves....except the flu which does generate even in vaccine form antibodies against neurons.

The anti-voltage gated potassium channel is responsible for hallucinations
anti-voltage-gated potassium channel antibodies associated encephalopathy is autoimmune
http://www.ncbi.nlm.nih.gov/pubmed/14960497
anti-voltage-gated potassium channel antibodies and auditory hallucinations
http://www.ncbi.nlm.nih.gov/pubmed/24571022
vgkc antibodies and seizures in cats
http://www.ncbi.nlm.nih.gov/pubmed/23278981
vgkc and children
http://www.ncbi.nlm.nih.gov/pubmed/21464429
potassium flow in schizophrenia and gene for the potassium channel
http://www.nih.gov/news/health/may2009/nimh-05.htm

The NMDA receptor seems to cause the mania, seizures, paranoia, and catatonic symptoms after flu like fevers
http://www.ncbi.nlm.nih.gov/pubmed/24731834
http://www.ncbi.nlm.nih.gov/pubmed/18807939
NMDA and narcolepsy
http://www.ncbi.nlm.nih.gov/pubmed/22569157
http://www.ncbi.nlm.nih.gov/pubmed/18446324
http://www.ncbi.nlm.nih.gov/pubmed/12611960

NMDA and fear
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263393/

The fungal kind of schizophrenia:

Hashimotos and encephalopathy
http://www.ncbi.nlm.nih.gov/pubmed/25116126
http://www.ncbi.nlm.nih.gov/pubmed/22474467 (with hallucinations)
autoantibodies against the NH2-terminal of a-enolase (NAE) as a specific diagnostic marker for HE
http://www.ncbi.nlm.nih.gov/pubmed/19363998
http://www.ncbi.nlm.nih.gov/pubmed/17335908

Hashimotos and voltage gated potassium channels are different from encephalopathy?
http://www.ncbi.nlm.nih.gov/pubmed/1507901

SJ and Schizophrenia
http://www.researchgate.net/publication/232431729_Relation_between_schizophrenic-like_psychosis_and_Sjogren's_syndrome_(SS)
http://www.ncbi.nlm.nih.gov/pubmed/3679782
http://www.ncbi.nlm.nih.gov/pubmed/22442099
http://www.ncbi.nlm.nih.gov/pubmed/16513876
http://www.hcplive.com/articles/Autoimmune-Disease-Schizophrenia-and-Bipolar-Disorder

NMDA and Sjogren's
http://www.ncbi.nlm.nih.gov/pubmed/15708887
http://www.ncbi.nlm.nih.gov/pubmed/16868971

Potassium deficiency and Candida...does this cause the malfunction of the channel?
http://www.livestrong.com/article/335327-potassium-deficiency-candida/

The T.gondii kind of schizophrenia:

t.gondii and encephal
http://en.wikipedia.org/wiki/Toxoplasmosis
http://www.ncbi.nlm.nih.gov/pubmed/14725265

Gluten and casein with schizophrenia
http://www.ncbi.nlm.nih.gov/pubmed/25241021

anti-gluten after t.gondii infects mice
http://www.ncbi.nlm.nih.gov/pubmed/23209841

schizophrenia and gluten sensitivity
http://www.ncbi.nlm.nih.gov/pubmed/22446142

malaria parasite and the potassium channel
http://www.science20.com/news_releases/disrupting_potassium_channel_in_malaria_parasite_blocks_transmission

T.gondii infects like the malaria parasite and involves the potassium channel? ???
http://www.science20.com/news_articles/toxoplasma_gondii_study_turns_parasite_invasion_theory_its_head-99796

My Older post of pan-apple domains, t.gondii, and the NMDA receptor

In our body when blood clots are degraded, plasminogen which has the PAN sequence in it, is activated by tPA (tissue plasminogen activator)

t-PA binds not just plasminogen but the NMDA receptor. Does this mean the NMDA receptor has a PAN/apple domain?

ref: t-PA is a new ligand of NMDA receptor
JBC papers Sept 23. 2004

t.gondii and pan-apple
http://connection.ebscohost.com/c/articles/77507454/novel-pan-apple-domain-containing-protein-from-toxoplasma-gondii-characterization-receptor-identification

If antibodies develop against T.gondii included the pan/apple domain does this mean the antibodies might also bind the NMDA receptor? and the over stimulation of the receptor would mean down regulation and hence the loss of fear initially seen?

CMV virus inhibits the expression of NMDA
http://www.ncbi.nlm.nih.gov/pubmed/15759129

viral infections or drugs are under consideration for the cross-targeting

the flu virus during pregnancy and schizophrenia
http://www.schizophrenia.com/prevention/maternal.html
the flu vaccine and narcolepsy which might overlap schizo
http://www.ncbi.nlm.nih.gov/pubmed/24849861
http://www.newscientist.com/article/dn24772-flu-vaccine-helps-unravel-complex-causes-of-narcolepsy.html#.VFo6_fnF-So

herpes virus 6 and 8 (these infect the neurons themselves and because they damage the mitochondria this might overlap with alzheimer's)
http://www.ncbi.nlm.nih.gov/pubmed/24139899
http://www.ncbi.nlm.nih.gov/pubmed/14991372
http://www.ncbi.nlm.nih.gov/pubmed/?term=herpesvirus+8+schizophrenia+2013
http://www.uptodate.com/contents/human-herpesvirus-6-infection-in-hematopoietic-cell-transplant-recipients
http://www.ncbi.nlm.nih.gov/pubmed/17981263

herpes 6 can reactivate cmv
http://jid.oxfordjournals.org/content/181/4/1450.long

CMV (Cytomegalovirus, also known as HCMV, CMV or Human Herpes virus 5 (HHV-5) )
http://www.ncbi.nlm.nih.gov/pubmed/24083998
http://www.ncbi.nlm.nih.gov/pubmed/25351544

Herv W
http://www.ncbi.nlm.nih.gov/pubmed/20100784
special note that T.gondii is currently under investigation for awakening herv
http://www.ncbi.nlm.nih.gov/pubmed/17054075
in other words T.gondii may create it's own cross-targeting reaction as part of the mind control

HIV?
http://www.ncbi.nlm.nih.gov/pubmed/11394192

Paranoid schizophrenia could be caused by dopamine high activity in the hippocampus
http://www.ncbi.nlm.nih.gov/pubmed/1349833

Meth causes dopamine disfunction of the hippocampus
http://www.ncbi.nlm.nih.gov/pubmed/20074221

cannabis and schizophrenia
http://www.ncbi.nlm.nih.gov/pubmed/16319402
http://www.ncbi.nlm.nih.gov/pubmed/10881971

extra note about t.gondii
http://www.ncbi.nlm.nih.gov/pubmed/11429165

Thursday, October 30, 2014

Spirochetes, the mitochondria, and Alzheimer's disease....is it really midichloria?

Alzheimer's I believe is a damaged mitochondria not an autoimmune disease. Damage can come from the herpes virus, diacytel, or Midochloria?

Borrelia spirochetes and Alzheimer's
http://www.ncbi.nlm.nih.gov/pubmed/15894409
http://www.ncbi.nlm.nih.gov/pubmed/15665404
http://www.ncbi.nlm.nih.gov/pubmed/8369471
http://www.ncbi.nlm.nih.gov/pubmed/18487847
http://www.ncbi.nlm.nih.gov/pubmed/21816039
http://www.ncbi.nlm.nih.gov/pubmed/7919164

Borrelia and primary biliary cirrhosis
http://www.ncbi.nlm.nih.gov/pubmed/16870516

anti-mitochondrial antibodies and biliary cirrhosis
http://www.ncbi.nlm.nih.gov/pubmed/14594130

You would think that I am trying to connect spirochetes and Alzheimer's but spirochetes don't damage mitochondrias. A bacteria that travels with them often does....

INSIDE the mitochondria infecting with lyme disease is Midichloria mitochondrii
http://forums.prohealth.com/forums/index.php?threads/bacteria-inside-mitochondria-in-lyme-tick.258328/

Is it spirochetes or is it really the bacteria midichloria that causes alzheimer's by damaging the mitochondria and making it unable to move?

My previous posts on Alzheimer's
http://angelabiggs.blogspot.com/2014/07/alzheimers-mitochondria-damage-from.html

Cross-targeting autoimmunity in parkinson's caused by Nocardia mycobacteria and a flu virus

Cross-targeting is when 2 infections target the immune system on one place and an autoimmune disease results. Parkinson's in this case is being considered an autoimmune disease.

Nocardia and parkinson's
http://articles.latimes.com/1990-05-17/news/mn-286_1_nocardia-infection
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC228573/
http://www.ncbi.nlm.nih.gov/pubmed/8420152
http://drbroxmeyer.netfirms.com/parkinsons.pdf
http://www.scielo.br/pdf/bjmbr/v37n4/5145.pdf
http://www.intechopen.com/books/mechanisms-in-parkinson-s-disease-models-and-treatments/filterable-forms-of-nocardia-an-infectious-focus-in-the-parkinsonian-midbrains

flu virus and parkinson's
http://www.ncbi.nlm.nih.gov/pubmed/21668692
http://www.ncbi.nlm.nih.gov/pubmed/22474298
http://www.ncbi.nlm.nih.gov/pubmed/23271861
http://www.parkinson.org/NationalParkinsonFoundation/files/6d/6dea0022-01a5-4d55-926c-42efa0084c18.pdf
https://www.michaeljfox.org/foundation/grant-detail.php?grant_id=711

http://www.stjude.org/stjude/v/index.jsp?vgnextoid=6dadedc5d21f2210VgnVCM1000001e0215acRCRD

Wednesday, October 22, 2014

Autoimmune Cross-targeting

The prevalence of autoimmune diseases continues to rise. The risk of celiac disease, type one diabetes, and autism have reached one in a hundred. What is happening?

We know that families can carry genetic dispositions for developing autoimmune diseases. The HLA gene is a risk factor for celiac disease but is not required for the development of the disease. The HLA gene is however a clue. HLAs are in essence the mailboxes for our Tcells to look for viral infections inside of cells. Seems logical to suspect a viral infection is involved in celiac disease.

We know that celiac patients tend to have a history of bladder infections so we could also suspect a bacterial infection. However when patients are examined the infection is often not present which suggests that these infection may merely be the triggers.

By definition an autoimmune disease is when the immune system attacks the patient's own body. How would the immune system confuse either of these infections with self? How are these infections triggers?

Cross-targeting. Two infections targeting one place.

My hypothesis is that cross-targeting occurs for all autoimmune diseases. This blog is dedicated to examining each autoimmune disease with their suspected infections and seeing if the pattern of cross-targeting exists.

Monday, October 13, 2014

IFN and strep

IF gluten and casein raise the IFN values too high then all infections that cross the BBB should be sensitive. Strep should be gluten and casein sensitive and IFN should appear in the meningitis forms and in the autoimmune associated diseases such as rheumatic fever and Sydenham chorea.

aging decreases beta IFN and people die from strep pneumoniae in lungs (stays in the lungs and macrophages are not triggered to eat the strep)
http://www.ncbi.nlm.nih.gov/pubmed/24670807

adherence of Strep to epithelial cells with IFN
http://www.ncbi.nlm.nih.gov/pubmed/7868244

Streptococcus pneumoniae meningitis
http://www.ncbi.nlm.nih.gov/pubmed/23071286

strep and ataxia
http://www.ncbi.nlm.nih.gov/pubmed/15814071

strep and pandas
http://pandasnetwork.org/strep-creates-inflammation-and-so-can-diet/

Pandas
http://www.foodsmatter.com/asd_autism/miscellaneous/articles/pandas.html

Gluten and Sydenham chorea
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569904/

IFN goes down in Sydenham chorea? Is that true for most autoimmune diseases?
http://www.ncbi.nlm.nih.gov/pubmed/12620654

a different autoimmune disease and IFN is lower
http://www.ncbi.nlm.nih.gov/pubmed/25272942

so even with lower IFN the sensitivity to gluten remains?

Curcumin and IFN
http://www.ncbi.nlm.nih.gov/pubmed/25251395
http://www.ncbi.nlm.nih.gov/pubmed/17979888

curcumin and sydenham chorea

Friday, October 3, 2014

Autoimmune cross-targeting and Treg confusion ?

My Hypothesis:
Cross-targeting: the layering of 2 different infections on one target causes autoimmune disease. A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria..etc.. infection marking the outside.

Tregs are T regulating cells with the "just right" goldilock's medium touch for looking into cells using the MHC mailboxes. The mailboxes hold up one piece at a time from inside. Tregs are not too weak or too strong when looking into the cells they spend just the right amount of time looking at the MHCs and they are conditioned to know all interior self proteins.

Specifically Tregs look into cells to see if they are infected with viruses or to protect any antibody labeled cells which are healthy and fine on the inside from being mistakenly killed as bacteria.

In suppressive mode the Tregs secrete il-10 creating tolerance. Il-10 is a cytokine that halts immune system attack. It is interesting to note that some viruses have developed evil il-10 homologs in order to stop the immune system from attacking. However under normal conditions the Treg expresses il-10 for tolerance when cross-reacting antibodies have marked a new area falsely because of molecular mimicry or the bad luck of a shared protein.

For example if e.coli breaks down red blood cells it creates bilirubin. The liver also breaks down red blood cells creating bilirubin. If antibodies against bilirubin show up as the immune system patrols your body the Treg would halt any attack on your liver by first checking the health of the marked liver cells and then secreting il-10.

Now considering cross-targeting: what if when the Treg arrives at the liver it finds that the liver cells are infected by a virus like betaretrovirus or hepatitis. The infection generating the antibodies bringing it here was actually from e.coli but now your treg won't secrete il-10. You have an overlap of infections causing autoimmunity because of confused Tregs. The Tregs have no idea what mode to go into. Is this possible?

Let us consider another example: George Eisenbarth found a latent period of type 1 diabetes where he could first see anti-islet antibodies until something triggered the rapid progression into autoimmunity. The flu and coxsackie are viruses that replicate in the pancreas. Both viruses have been implicated in diabetes because new cases of type 1 diabetes appear during outbreaks. Could these viruses be the rapid trigger Eisenbarth was looking for? Could this be cross-targeting and Treg confusion?

Celiac and treg
http://www.ncbi.nlm.nih.gov/pubmed/23874626

type 1 diabetes and treg
http://www.jimmunol.org/content/181/7/4516.full.pdf

Rheumatoid arthritis and treg
http://deepblue.lib.umich.edu/bitstream/handle/2027.42/55983/22415_ftp.pdf?sequence=1

Autoimmune liver disease and treg
http://www.hindawi.com/journals/jir/2013/607073/

e.coli and the liver primary biliary cirrhosis
http://www.ncbi.nlm.nih.gov/pubmed/24128311

betaretrovirus and primary biliary cirrhosis
http://www.pnas.org/content/100/14/8454

il-2 and tregs
http://www.jimmunol.org/content/172/7/3983.full

treg cells are antigen dependent
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784904/

Fox and Treg
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008159/

primary biliary cirrhosis and cross-targeting

My Hypothesis:
Cross-targeting: the layering of 2 different infections on one target causes autoimmune disease. A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria..etc.. infection marking the outside.

e.coli and the liver primary biliary cirrhosis
http://www.ncbi.nlm.nih.gov/pubmed/24128311

betaretrovirus and primary biliary cirrhosis
http://www.pnas.org/content/100/14/8454

note that this group with e.coli would overlap celiac disease
while the mycoplasma group would overlap RA

the areas over autoimmune disease overlap my help elucidate the infections involved

Wednesday, October 1, 2014

Enterovirus 68, transverse myelopathy, and autoimmune cross-targeting. Predicting who is susceptible in Denver.

Monday, September 29, 2014

Gluten and Casein signifies that infections are crossing the major barriers: the intestine or the blood-brain-barrier !!!

Gluten and casein sensitivity may mean that an infection has broken through a tight barrier like the intestine or brain's blood barrier.

Does casein-alpha or gluten alter the IFN which then allows the BBB or the lumen to open for bacterial infections to cross?

Under normal conditions IFN is a cytokine, a immune system message, to tell macrophages to come eat something. If IFN levels are raised too high in an area the barrier wall epithelial layer goes through changes. (zonulin included ) Which means that infections which try to cross either the blood brain barrier or the lumen would have an easier time.

The hypothesis is that the high IFN levels from a gluten and casein sensitive state would create antibodies but not autoimmune disease until a virus infects the same area causing cross-targeting.

Cross-targeting autoimmune hypothesis is 2 infections on one target, one organ, confuse the immune system into attacking self. An outer infection to uncouple the B cell's education and an inner infection to uncouple a T cell's education.

Gluten sensitivity alone is not an indicator of autoimmune disease rather that an infection exists that breaks barriers.

First let us look at the gluten and casein connection to IFN.

differences alpha, beta, gamma IFN
http://www.ncbi.nlm.nih.gov/pubmed/7993128

all are involved with cell growth inhibition in addition to being part of the immune system cytokines against viruses...all can open the Blood Brain Barrier or BBB

Casein-alpha upregulates IFN-alpha genes thus functions as a tumor suppressor
http://www.landesbioscience.com/journals/cc/2012CC4423.pdf

temporary bbb crossing blocked but long term opens it?
http://www.researchgate.net/publication/5257154_Interferon-beta_prevents_cytokine-induced_neutrophil_infiltration_and_attenuates_blood-brain_barrier_disruption

Gluten stimulates more IFN-gamma expression is gluten inhibiting it?
http://www.gastrojournal.org/article/S0016-5085%2898%2970134-9/abstract
http://www.ncbi.nlm.nih.gov/pubmed/9721152
http://www.ncbi.nlm.nih.gov/pubmed/23588237
http://www.ncbi.nlm.nih.gov/pubmed/17919493

IFN-γ participates in cerebral malaria pathogenesis by affecting endothelial integrity
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133756/

f-actin and gluten
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1809109/

e.coli, f-actin and the BBB
http://www.ncbi.nlm.nih.gov/pubmed/24932957

casein from milk increases mycobacteria invasion
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459753/

B-casein from bacteria and cellular motility /invasion?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC275444/
pretty pictures of what casein induces and the visualizing of actin (same article)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC275444/figure/cdg586f4/

Current hypothesis list of gluten and casein sensitive culprits connected to autoimmune diseases:

e.coli celiac
sutterella autism
mycobacteria psoriasis/parkinson's
t.gondii schizophrenia
strep tourettes (non genetic)

e.coli and gluten
http://www.ncbi.nlm.nih.gov/pubmed/26456581

Strep and gluten
http://www.ncbi.nlm.nih.gov/pubmed/15814071

t.gondii and gluten sensitivity
http://www.ncbi.nlm.nih.gov/pubmed/23209841

psoriasis and gluten
http://www.ncbi.nlm.nih.gov/pubmed/25603678

psoriasis and mycobacteria

gluten and pychosis
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517012/

If they all are gluten sensitive because they cross the BBB (blood brain barrier) does that mean that Strep would be gluten sensitive because it is notorious for crossing and has been known to be involved with PANDAS which involves antibodies passing through a BBB to get to the brain.

Anyone out there able to look at strep and see if it is gluten and casein sensitive?
http://www.ncbi.nlm.nih.gov/pubmed/15814071
http://curemyth1.org/forum2/3860.html
http://wheatfreediseasefree.com/2012/04/23/keep-the-tonsils-pull-the-strep-throat/
We so quickly give people antibiotics I am not sure we will know.

strep and OCD?
http://www.ncbi.nlm.nih.gov/pubmed/15995031

OCD and gluten? is this strep or e.coli
http://www.ncbi.nlm.nih.gov/pubmed/?term=ocd+gluten

In case you did not know that e.coli crossed the BBB
http://iai.asm.org/content/69/9/5217.full?sid=41faac6f-bc5d-4015-bd6d-8f733682da01

strep and ataxia
http://www.ncbi.nlm.nih.gov/pubmed/15814071

Zonulin is also an interesting dimension appearing at the lumen of the gut and the blood brain barrier
http://www.ncbi.nlm.nih.gov/pubmed/23637756
http://www.ncbi.nlm.nih.gov/pubmed/22731712

How does all this fit together? Transglutaminase and cross-targeting?

viral infections can cause the generation of Transglutaminase
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810 390/

further EBV may set off more than one type of colon autoimmune disease (not just celiac)
http://www.ncbi.nlm.nih.gov/pubmed/10364028

Infections like e.coli or strep which would cross the lumen or BBB with increased ease with gluten and casein would already have the generated and immune attack there in the colon but it would not be autoimmune until cross-targeted with a virus.

In other words it is not the "crossing of gluten and casein" that we should fear rather the cross-targeting of infections and the antibodies that target us.

3/5/2015 new post http://angelabiggs.blogspot.com/2015/03/infections-that-break-tight-junction.html

New paper linking intestinal lumen and the BBB. When the intestine becomes stronger so does the BBB.
http://www.ncbi.nlm.nih.gov/pubmed/25411471

Guillain barre syndrome and autoimmune cross-targeting

Guillain Barre

Old blog post: http://angelabiggs.blogspot.com/2013/04/does-location-of-bacteria-decide-which.html

Current virus hitting denver and paralysis is not Guillan Barre
http://abcnews.go.com/Health/cdc-investigates-limb-paralysis-children-enterovirus-68-outbreak/story?id=25804998
They found anti-phospholipid antibodies. So it is the autoimmune disease transverse myelopathy which overlaps sjogren's.
http://www.ncbi.nlm.nih.gov/pubmed/10930601

My Hypothesis:
Cross-targeting: the layering of 2 different infections on one target causes autoimmune disease. A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria..etc.. infection marking the outside.

In the case of Guillain Barre

Campylobacter jejuni
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC128258/
http://www.ncbi.nlm.nih.gov/pubmed/24107359
http://www.ncbi.nlm.nih.gov/pubmed/16829615

Enterovirus
http://www.ncbi.nlm.nih.gov/pubmed/16269848

other viruses might trigger the cross-targeting
http://www.ncbi.nlm.nih.gov/pubmed/24800041

c.jejuni and the lungs ??? some cases of asthma????
http://www.unboundmedicine.com/medline/citation/24611115/Campylobacter_jejuni_infection_of_infant_mice:_acute_enterocolitis_is_followed_by_asymptomatic_intestinal_and_extra_intestinal_immune_responses_

Indirect connection H.pylori protects against early on-set asthma and c.jejuni
http://www.ncbi.nlm.nih.gov/pubmed/?term=c.+jejuni+asthma

Sunday, September 28, 2014

Cross-targeting autoimmune hypothesis and rheumatic fever?

Friday, September 26, 2014

Are cataracts caused by autoimmunity?

Tuesday, September 23, 2014

Lupus vs. Sjogren can you separate them with transglutaminase?

This board is still under construction

Higher levels of transglutaminase in Sjogren's than in Lupus and RA
http://www.ncbi.nlm.nih.gov/pubmed/21413148

Candida and transglutaminase: the Hypyal wall protein is a substrate for transglutaminase and is involved with the attachment to epithelial walls
http://www.jbc.org/content/279/39/40737.full

the gluten and casein could be triggering dimorphic switching fungal infections (mold to yeast) but which enzyme it would be acting on is unknown but this would be anti-gluten not anti-transglutaminase....but is it lupus or sjogren that has gluten: http://ard.bmj.com/content/63/11/1501.full
sjogren has the gluten sensitivity : http://www.ncbi.nlm.nih.gov/pubmed/17613926
http://www.ncbi.nlm.nih.gov/pubmed/13680146
http://celiacdisease.about.com/od/commoncomplicationsofcd/a/Celiac-Disease-Sjogrens-Syndrome.htm

Lupus and RA have Wibg antibodies???? do mycoplasmas use them???? Later post

If fungal infections are involved with Sjogren's, Hashimoto's, vitiligo, colitis, and asperger's....are all of these associated with higher Transglutaminase antibodies?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604853
which is a vitiligo paper

Found at high levels in both Lupus and sjogren is ROs and correlated with Rheumatoid factor? What is common here between mycoplasmas and fungal infections that would do this?
http://www.ncbi.nlm.nih.gov/pubmed/1603204

RA, stroke, irregular heartbeats, and mycoplasmas?

Looking at patterns of overlap....

RA/lupus and stroke
http://www.ncbi.nlm.nih.gov/pubmed/24898360
http://www.ncbi.nlm.nih.gov/pubmed/22214618

RA/lupus and irregular heart beats (arrhythmias)
http://www.ncbi.nlm.nih.gov/pubmed/24633413
http://www.ncbi.nlm.nih.gov/pubmed/24050965

mycoplasmas and stroke
http://www.ncbi.nlm.nih.gov/pubmed/24223604
http://www.ncbi.nlm.nih.gov/pubmed/21799166

mycoplasmas and irregular heartbeats (arrhythmias)
http://www.ncbi.nlm.nih.gov/pubmed/6179447
http ://www.ncbi.nlm.nih.gov/pubmed/6816867

Thursday, September 18, 2014

juvenile idiopathic arthritis and celiac disease....e.coli?

Hypothesis:
Cross-targeting: the layering of 2 different infections on one target causes autoimmune disease. A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria..etc.. infection marking the outside.

http://www.ncbi.nlm.nih.gov/pubmed/23448357

Celiac aand Juvenile idopathic arthritis
http://www.ncbi.nlm.nih.gov/pubmed/22472933
http://www.ncbi.nlm.nih.gov/pubmed/15695302

e.coli and JIA
http://www.ncbi.nlm.nih.gov/pubmed/17469159

urinary track infection and JIA
http://www.ehealthme.com/cs/juvenile+arthritis/urinary+tract+infection

reactive arthritis and urinary tract infections
http://www.niams.nih.gov/Health_Info/Reactive_Arthritis/

do kids with JIA get Dermatitis Herpetiformis (blistering chronic skin disease)?

celiac and uvetis
http://www.ncbi.nlm.nih.gov/pubmed/22408231
http://link.springer.com/article/10.1007%2Fs00296-009-1177-z#page-1

chronic uveitis (arthritis of the eye) and JIA
http://www.ncbi.nlm.nih.gov/pubmed/16395772
http://www.ncbi.nlm.nih.gov/pubmed/21378109
http://www.ncbi.nlm.nih.gov/pubmed/15693100

virus triggered
http://www.ncbi.nlm.nih.gov/pubmed/22825024

schnitzler syndrome? how rare is this?
http://www.ncbi.nlm.nih.gov/pubmed/23812931
http://www.ncbi.nlm.nih.gov/pubmed/18371052

the adult stiff syndrome and some children with JIA ...not the same thing!!
http://www.ncbi.nlm.nih.gov/pubmed/20676642

Wednesday, September 17, 2014

discord lupus and Vitiligo with autoimmune cross-targeting?

Tuesday, September 16, 2014

Is idopathic thrombocytopenic purpura caused by cross-targeting autoimmunity? H.pylori and zika?

Idopathic thrombocytopenic purpura

Cross-targeting: the layering of 2 different infections on one target causing autoimmune disease. A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria..etc.. infection marking the outside.

In most cases of Idopathic thrombocytopenic purpura, H.pylori marks the outside of the host's platelets.

ITP antibodies to platelets
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1538143/

Eradication of H.pyloir has been shown to help or cure ITP

H. pylori
http://www.ncbi.nlm.nih.gov/pubmed/24505529
http://www.ncbi.nlm.nih.gov/pubmed/21120192
http://www.ncbi.nlm.nih.gov/pubmed/15765778
http://www.ncbi.nlm.nih.gov/pubmed/11157503

note that H. pylori replicates inside of bone marrow derived dendritic cells and it would be a small leap to believe that it could eventually infect other bone marrow derived cells like platelets or in infecting these types of marrow cells accidentally triggering antibodies toward platelets

The question I have : do other spirochetes infect the bone marrow? Does syphillis' t. pallidum or lyme's b.burgdorferi or the dog spirochete leptospira???

However other infections can cause ITP...the key is that they generate antibodies against platelets. Here are examples of mycoplasmas: http://www.ncbi.nlm.nih.gov/pubmed/19474700
http://www.ncbi.nlm.nih.gov/pubmed/19474700
(the mycoplasma cases would have RA)

More than one virus may be able to cause the necessary cross-targeting on platelets but they must somehow infect or generate antibodies against platelets:

Flaviviruses infect bone marrow and should trigger it
dengue and ITP
http://www.ncbi.nlm.nih.gov/pubmed/24879007
http://www.ncbi.nlm.nih.gov/pubmed/26434084
http://www.ncbi.nlm.nih.gov/pubmed/25728040

Added 4/30/1016 : Zika and ITP
http://www.theguardian.com/world/2016/apr/30/zika-virus-symptoms-american-death-puerto-rico-risks

Hepatitis C and ITP
http://www.ncbi.nlm.nih.gov/pubmed/24457056
http://cid.oxfordjournals.org/content/39/6/790.full

Hepatitis C infecting the bone marrow (which would include platelet cells)
http://www.ncbi.nlm.nih.gov/pubmed/21188328

influenza A and ITP
http://www.ncbi.nlm.nih.gov/pubmed/15614463
http://www.ncbi.nlm.nih.gov/pubmed/21962253

Influenza A absorbed by platelets
http://www.bloodjournal.org/content/28/2/213?sso-checked=true

Note that there is a strong overlap with Primary biliary cirrhosis (an autoimmune disease of the liver) and ITP
http://www.ncbi.nlm.nih.gov/pubmed/9185750 which makes sense because some of these infections are known to infect liver cells in addition to the fact that the liver filters the blood.